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13 条记录 (耗时 0.012 秒)

    1,4-Dihydropyridine derivatives
    8.
    发明公开
    1,4-Dihydropyridine derivatives 失效
    -1,4-二氢吡啶衍生物在。

    公开(公告)号：EP0320984A2

    公开(公告)日：1989-06-21

    申请号：EP88121142.9

    申请日：1988-12-16

    申请人： FUJIREBIO INC.

    发明人： Ikawa, Hiroshi ,  Kadoiri, Akiyoshi ,  Kobayashi, Nobuo ,  Yamaura, Tetsuaki ,  Kase, Noriko ,  Kita, Hiromi

    IPC分类号： C07D401/12 ,  C07D401/14 ,  A61K31/47 ,  A61K31/44 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12

    摘要： 1,4-Dihydropyridine derivatives of the formula (I) having vasodilative activity and inhibitory activity on platelet aggregation:
    wherein Ar¹ represents an aromatic hydrocarbon group or heterocyclic group which may have at least one substituent; R¹ represents a hydrocarbon group which may have at least one substituent; A and B each represent a hydrocarbon group which may have at least one substituent, in which any of the carbon atoms in the main chain thereof may be replaced by a nitrogen atom or an oxygen atom; Ar² represents an aromatic hydrocarbon group or heterocyclic group; Ar³ represents a heterocyclic group which may have at least one substituent; and n is 0 or 1.

    摘要翻译： 具有血管扩张活性和血小板聚集抑制活性的式（I）的1,4-二氢吡啶衍生物：其中Ar 1表示可具有至少一个取代基的芳族烃基或杂环基; R 1表示可以具有至少一个取代基的烃基; A和B各自表示可以具有至少一个取代基的烃基，其中主链中的任何一个碳原子可以被氮原子或氧原子代替; Ar 2表示芳族烃基或杂环基; Ar 3表示可具有至少一个取代基的杂环基; n为0或1。

    3,5-Dihydroxyheptanoic acid derivatives and lactones thereof as HMG-CoA reductase inhibitors
    9.
    发明公开
    3,5-Dihydroxyheptanoic acid derivatives and lactones thereof as HMG-CoA reductase inhibitors 失效
    3,5-Dihydroxyheptansäurederivateund deren Lactone als HMG-CoA-Reduktase-Inhibitoren。

    公开(公告)号：EP0539709A1

    公开(公告)日：1993-05-05

    申请号：EP92115829.1

    申请日：1992-09-16

    申请人： FUJIREBIO Inc.

    发明人： Matsumoto, Masakatsu ,  Watanabe, Nobuko ,  Mori, Eiko ,  Yamaura, Tetsuaki ,  Aoyama, Misao

    IPC分类号： C07D407/06 ,  C07D307/79 ,  C07D405/04 ,  C07D405/14 ,  A61K31/34

    CPC分类号： C07D307/79 ,  C07D405/04 ,  C07D405/14 ,  C07D407/06

    摘要： 3,5-Dihydroxyheptanoic acid derivatives of formula (I) and formula (II) have an inhibition effect on HMG-CoA reductase, a cholesterol value reduction effect, and an antioxidation function, thus serving as cholesterol reducing agent or lipid reducing agents:

    wherein R¹ represents hydrogen, a nitro group, or -N(R⁴)R⁵ in which R⁴ and R⁵ each represent an alkyl group, an alkenyl group, an aryl group, an aralkyl group; an acyl group, an aroyl group, a carbamoyl group, or a thiocarbamoyl group, and R⁴ and R⁵ may be combined to form a cyclic amino group; and R² and R³ each represent hydrogen or an alkyl group; and R⁶ represents hydrogen, an alkyl group, an alkali metal, or an alkaline earth metal.

    摘要翻译： 式（I）和式（II）的3,5-二羟基庚酸衍生物对HMG-CoA还原酶具有抑制作用，降低胆固醇的作用和抗氧化功能，因此用作胆固醇降低剂或降脂剂： CHEM>其中R 1表示氢，硝基或-N（R 4）R 5，其中R 4和R 5各自表示烷基，烯基，芳基，芳烷基; 酰基，芳酰基，氨基甲酰基或硫代氨基甲酰基，R4和R5可以组合形成环氨基; R 2和R 3各自表示氢或烷基; R6代表氢，烷基，碱金属或碱土金属。

    Naphthoic acid derivative
    10.
    发明公开
    Naphthoic acid derivative 失效
    Naphtoesäure - 衍生金融工具。

    公开(公告)号：EP0492178A2

    公开(公告)日：1992-07-01

    申请号：EP91120553.2

    申请日：1991-11-29

    申请人： FUJIREBIO INC.

    发明人： Sekine, Yasuo ,  Yamaura, Tetsuaki ,  Nishimura, Masato, Fuji Rebio Hachiojiryo ,  Kojima, Eri ,  Emoto, Yasuko ,  Higashide, Yasushi

    IPC分类号： C07D333/18 ,  C07D207/12 ,  C07D295/12 ,  C07D213/32 ,  C07D213/38 ,  C07D211/46 ,  C07D213/30 ,  C07D307/38 ,  C07D401/12 ,  A61K31/38 ,  A61K31/40

    CPC分类号： C07D213/30 ,  C07D211/46 ,  C07D211/54 ,  C07D213/32 ,  C07D213/38 ,  C07D295/13 ,  C07D307/38 ,  C07D317/56 ,  C07D333/18 ,  C07D333/28 ,  C07D401/12

    摘要： A naphthoic acid derivative represented by the following general formula or a salt thereof:
    wherein R i , R 2 and R 3 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group or an aralkyloxy group;

    R 4 is a hydrogen atom or a lower alkyl group;
    R 5 is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaromatic group;
    X is a group

    a cycloalkylene group, a bivalent nitrogen-containing heterocyclic group, or a group


    -R 8 - NH- or -NH-R 8 , where R 6 and R 7 are each a hydrogen atom or a lower alkyl group and R 8 is a cycloalkylene group, or R 6 and R 7 , together with R 4 , may form an alkylene group of 1-3 carbon atoms;
    Y is -S(O)p-, -(CH 2 ) n - or -0-;
    Z is a substituted or unsubstituted alkylene group or a single bond;
    ℓ is an integer of 0-4;
    m is an integer of 0-8;
    n is 0 or 1;
    p is an integer of 0-2; and
    g is 0 or 1.
    The compound is useful as an antiallergic agent.

    摘要翻译： 由以下通式表示的萘甲酸衍生物或其盐：其中R 1，R 2和R 3各自独立地为氢原子，卤素原子，羟基，低级烷基，低级烷氧基， 低级烷酰氧基，羟基低级烷基，低级烷氧基 - 低级烷基，低级烷酰氧基 - 低级烷基或芳烷氧基; R4是氢原子或低级烷基; R5是取代或未取代的芳基或取代或未取代的杂芳基; X为环状亚烷基，二价含氮杂环基，或基团 -R8-NH-或-NH-R8，其中R6和R7各自为氢原子或低级烷基 并且R 8为亚环烷基，或者R 6和R 7与R 4一起可以形成1-3个碳原子的亚烷基; Y是-S（O）对 - ， - （CH 2）n - 或-O-; Z是取代或未取代的亚烷基或单键; l是0-4的整数; m为0-8的整数; n为0或1; p是0-2的整数; 并且g为0或1.该化合物可用作抗过敏剂。