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公开(公告)号：EP1087987A1
公开(公告)日：2001-04-04
申请号：EP99939799.5
申请日：1999-06-16
IPC分类号： C07J3/00 , C12R1/645 , A61K31/575
CPC分类号： C12R1/645 , C07J63/008 , C12P19/60 , Y10S435/911
摘要： The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided are a pharmaceutical composition comprising the compound and pharmaceutically acceptable carrier, a use of the WF002 as a medicament and use of the compound for manufacture of the medicament for treatment of infectious disease.
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公开(公告)号：EP0983297A1
公开(公告)日：2000-03-08
申请号：EP98919630.8
申请日：1998-05-18
发明人： HORI, Yasuhiro , TSURUMI, Yasuhisa , TAKASE, Shigehiro , HATANAKA, Hiroshi , SAKAMOTO, Kazutoshi , HASHIMOTO, Seiji , OHKI, Hidenori , TOJO, Takashi , MATSUDA, Keiji , KAWABATA, Kohji
摘要： The invention relates to new polypeptide compounds represented by formula (I), wherein R1 is hydrogen, etc., R2 is hydrogen, etc., R3 is hydrogen, etc., and R4 is hydrogen, etc., or a salt thereof which have antimicrobial activities (especially antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia in a human being or an animal.
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公开(公告)号：EP0591534A1
公开(公告)日：1994-04-13
申请号：EP92911803.2
申请日：1992-06-12
发明人： NAKAJIMA, Hidenori , HORI, Yasuhiro , GOTO, Toshio , TAKASE, Shigehiro , VERHAEGHE, Koen , TERANO, Hiroshi , OKUHARA, Masakuni
摘要： Substances WB2663A, WB2663B and WB2663C are produced by culturing a WB2663-producing bacterium belonging to the genus Pseudomonas to form physiologically active substances and isolating therefrom neutral substances respectively having the following specific rotation: [α]²³ = -36° (C =0.5 in CH₂Cl₂),[α]²³ = -12° (C =0.5 in CH₂Cl₂), and [α]²³ = -9° (C =0.5 in CH₂Cl₂). They have each an excellent antitumor activity.
摘要翻译： 物质WB2663A，WB2663B和WB2663C通过培养属于假单胞菌属的产WB2663的细菌以形成生理活性物质并从中分离出分别具有如下比旋光度的中性物质：[α] 23 = -36°（C = 0.5英寸 CH 2 Cl 2），[α] 23 = -12°（CH 2 Cl 2中C = 0.5）和[α] 23 = -9°（CH 2 Cl 2中C = 0.5）。 他们每个人都有出色的抗肿瘤活性。
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公开(公告)号：EP1087987B1
公开(公告)日：2002-08-14
申请号：EP99939799.5
申请日：1999-06-16
IPC分类号： C07J3/00 , C12R1/645 , A61K31/575
CPC分类号： C12R1/645 , C07J63/008 , C12P19/60 , Y10S435/911
摘要： The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided are a pharmaceutical composition comprising the compound and pharmaceutically acceptable carrier, a use of the WF002 as a medicament and use of the compound for manufacture of the medicament for treatment of infectious disease.
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5.发明公开
公开(公告)号：EP1064299A1
公开(公告)日：2001-01-03
申请号：EP99939845.6
申请日：1999-03-12
摘要： The present invention provides a new antimicrobial compound WF14573, and a process for producing WF14573 by (a) culturing a WF14573 A and/or B-producing microorganism in a nutrient medium and recovering WF14573 A and/or B from the resultant cultured broth or (b) deacylating WF14573 A and/or B in the presence of a microbial substance which is capable of deacylating WF14573 A and/or B. Also provided are an antimicrobial agent comprising WF14573 and carrier(s), a pharmaceutical composition comprising an effective amount of WF14573 and pharmaceutically acceptable carrier(s), a method for killing microorganisms by applying WF14573 to the microoganisms, and use of WF14573 for the treatment of infectious diseases caused by pathogenic microoganisms.
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公开(公告)号：EP0591534B1
公开(公告)日：1996-11-06
申请号：EP92911803.2
申请日：1992-06-12
发明人： NAKAJIMA, Hidenori , HORI, Yasuhiro , GOTO, Toshio , TAKASE, Shigehiro , VERHAEGHE, Koen , TERANO, Hiroshi , OKUHARA, Masakuni
摘要： Substances WB2663A, WB2663B and WB2663C are produced by culturing a WB2663-producing bacterium belonging to the genus Pseudomonas to form physiologically active substances and isolating therefrom neutral substances respectively having the following specific rotation: [ alpha ] = -36 DEG (C =0.5 in CH2Cl2),[ alpha ] = -12 DEG (C =0.5 in CH2Cl2), and [ alpha ] = -9 DEG (C =0.5 in CH2Cl2). They have each an excellent antitumor activity.
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