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9 条记录 (耗时 0.044 秒)

    CYCLIC TETRAPEPTIDES AND THEIR USE AS HISTONE DEACETYLASE INHIBITOR
    2.
    发明公开
    CYCLIC TETRAPEPTIDES AND THEIR USE AS HISTONE DEACETYLASE INHIBITOR 审中-公开
    骑行TETRA肽及其作为蛋白去乙酰化酶抑制剂

    公开(公告)号：EP1123309A2

    公开(公告)日：2001-08-16

    申请号：EP99970393.7

    申请日：1999-10-08

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： MORI, Hiroaki ,  SAKAMOTO, Kazutoshi ,  TSURUMI, Yasuhisa ,  TAKASE, Shigehiro ,  HINO, Motohiro

    IPC分类号： C07K5/12 ,  C12P21/04 ,  C12R1/645 ,  A61K38/12 ,  A61P33/02 ,  A61P35/00 ,  A61P37/00

    CPC分类号： A61K38/12 ,  C07K5/126

    摘要： A cyclic tetrapeptide compound and use thereof. Especially, a compound WF27082, a process for production of the compound by culturing, in a nutrient medium, a WF27082-producing strain belonging to Acremonium and recovering the compound from a culture broth, a pharmaceutical composition containing the compound as an active ingredient, in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, the compound for use as a medicament, a use of the compound for manufacture of a medicament for inhibiting histone deacetylase, a use of the compound for manufacture of a medicament for treating or preventing inflammatory disorders, diabetes, diabetic complications, homozygous thalassemia, fibrosis, cirrhosis, acute promyelocytic leukaemia (APL), protozoal infections, organ transplant rejections, autoimmune diseases, or tumors, a use of histone deacetylase inhibitors as an immunosuppressant or an antitumor agent, and a use of histone deacetylase inhibitors for manufacture of a medicament for treating or preventing organ transplant rejections, autoimmune diseases or tumors are described.

    CYCLOHEXAPEPTIDE WF14573 OR ITS SALT, PRODUCTION THEREOF AND USE THEREOF
    6.
    发明公开
    CYCLOHEXAPEPTIDE WF14573 OR ITS SALT, PRODUCTION THEREOF AND USE THEREOF 审中-公开
    环六WF14573，其生产和使用

    公开(公告)号：EP1064299A1

    公开(公告)日：2001-01-03

    申请号：EP99939845.6

    申请日：1999-03-12

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： HORI, Yasuhiro ,  TAKASE, Shigehiro ,  TSURUMI, Yasuhisa ,  HASHIMOTO, Michizane ,  HINO, Motohiro

    IPC分类号： C07K7/56 ,  A61K38/12 ,  C12P21/04

    CPC分类号： C07K7/56 ,  A61K38/00

    摘要： The present invention provides a new antimicrobial compound WF14573, and a process for producing WF14573 by (a) culturing a WF14573 A and/or B-producing microorganism in a nutrient medium and recovering WF14573 A and/or B from the resultant cultured broth or (b) deacylating WF14573 A and/or B in the presence of a microbial substance which is capable of deacylating WF14573 A and/or B. Also provided are an antimicrobial agent comprising WF14573 and carrier(s), a pharmaceutical composition comprising an effective amount of WF14573 and pharmaceutically acceptable carrier(s), a method for killing microorganisms by applying WF14573 to the microoganisms, and use of WF14573 for the treatment of infectious diseases caused by pathogenic microoganisms.

    PROCESS FOR PREPARING FR900482 AND COMPOUNDS ANALOGOUS THERETO
    7.
    发明公开
    PROCESS FOR PREPARING FR900482 AND COMPOUNDS ANALOGOUS THERETO 失效
    VERFAHREN ZUR HERSTELLUNG VON FR900482 UND ANALOGE VERBINDUNGEN

    公开(公告)号：EP0943689A1

    公开(公告)日：1999-09-22

    申请号：EP97909655.9

    申请日：1997-10-28

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： TSUBOI, Masaru ,  SHIMIZU, Shiho ,  YAMASHITA, Michio ,  TSURUMI, Yasuhisa ,  HASHIMOTO, Seiji

    IPC分类号： C12P17/18 ,  C12N1/14

    CPC分类号： C12P17/188 ,  Y10S435/929

    摘要： A process for preparing compounds represented by general formula (I), wherein R 1 represent hydrogen, a lower alkanoyl group or a lower alkyl group; and R 2 and R 3 represent each hydrogen or a lower alkanoyl group, characterized by reacting a culture of a strain belonging to the genus Fusarium or cells obtained by the filtration of the culture with a compound represented by general formula (II) wherein R 1 , R 2 , and R 3 are each as defined above.

    摘要翻译： 一种制备由通式（I）表示的化合物的方法，其中R 1表示氢，低级烷酰基或低级烷基; R 2和R 3代表每个氢或低级烷酰基，其特征在于使属于镰刀菌属的菌株的培养物或通过过滤培养物得到的细胞与通式（II）表示的化合物反应 ）其中R 1，R 2和R 3各自如上所定义。