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公开(公告)号：EP0788511B1
公开(公告)日：2002-12-11
申请号：EP95932935.0
申请日：1995-09-29
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公开(公告)号：EP0983297A1
公开(公告)日：2000-03-08
申请号：EP98919630.8
申请日：1998-05-18
发明人： HORI, Yasuhiro , TSURUMI, Yasuhisa , TAKASE, Shigehiro , HATANAKA, Hiroshi , SAKAMOTO, Kazutoshi , HASHIMOTO, Seiji , OHKI, Hidenori , TOJO, Takashi , MATSUDA, Keiji , KAWABATA, Kohji
摘要： The invention relates to new polypeptide compounds represented by formula (I), wherein R1 is hydrogen, etc., R2 is hydrogen, etc., R3 is hydrogen, etc., and R4 is hydrogen, etc., or a salt thereof which have antimicrobial activities (especially antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia in a human being or an animal.
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公开(公告)号：EP0941237A1
公开(公告)日：1999-09-15
申请号：EP97912495.0
申请日：1997-11-18
发明人： KANASAKI, Ryuichi , TAKASE, Shigehiro , HASHIMOTO, Michizane , HATANAKA, Hiroshi , SAKAMOTO, Kazutoshi , HASHIMOTO, Seiji , SHIRAISHI, Nobuyuki , OHKI, Hidenori , KAWABATA, Kohji
摘要： This invention relates to new polypeptide compounds represented by formula (I), wherein R1 is as defined in the description or a salt thereof, which have antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to a process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
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4.发明公开
公开(公告)号：EP0715626A1
公开(公告)日：1996-06-12
申请号：EP94924396.0
申请日：1994-08-22
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： A compound of formula (I) in which R?1 and R2¿ are each hydrogen or lower alkyl, R3 is optionally substituted quinolyl or oxide thereof, and X and Y are each hydrogen, halogen, cyano or lower alkyl, or pharmaceutically acceptable salts thereof, which has antimicrobial acivity.
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公开(公告)号：EP1173472A1
公开(公告)日：2002-01-23
申请号：EP00917469.9
申请日：2000-04-25
发明人： TOJO, Takashi , OHKI, Hidenori , SHIRAISHI, Nobuyuki , MATSUYA, Takahiro , MATSUDA, Hiroshi , MURANO, Kenji , BARRETT, David , OGINO, Takashi , MATSUDA, Keiji , ICHIHARA, Masaharu , HASHIMOTO, Norio , KANDA, Atsushi , OHIGASHI, Atsushi
摘要： This invention relates to new polypeptide compound represented by general formula (I), wherein R?1, R2, R3, R4, R5 and R6¿ are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical compositon comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
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公开(公告)号：EP1053247A1
公开(公告)日：2000-11-22
申请号：EP99902855.8
申请日：1999-02-05
发明人： OHKI, Hidenori , MURANO, Kenji , TOJO, Takashi , SHIRAISHI, Nobuyuki , MATSUYA, Takahiro , MATSUDA, Hiroshi , MIZUNO, Hiroaki , BARRETT, David , MATSUDA, Keiji , KAWABATA, Kohji
摘要： This invention relates to new polypeptide compounds represented by general formula (I), wherein R?1, R2, R3 and R4¿ are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
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公开(公告)号：EP0674645A1
公开(公告)日：1995-10-04
申请号：EP94903000.0
申请日：1993-12-15
发明人： TAKAYA, Takao , SAKANE, Kazuo , MIYAI, Kenzi , KAWABATA, Kohji , OKUDA, Shinya , OHKI, Hidenori , YAMANAKA, Hideaki
CPC分类号： C07D501/00
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公开(公告)号：EP0941236A1
公开(公告)日：1999-09-15
申请号：EP97912494.0
申请日：1997-11-18
摘要： This invention relates to new polypeptide compounds represented by general formula (I), wherein R?1 and R2¿ are as defined in the description and pharmaceutically acceptable salt thereof which have antimicrobial activities (especially antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious disease including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia in a human being or an animal.
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公开(公告)号：EP0788511A1
公开(公告)日：1997-08-13
申请号：EP95932935.0
申请日：1995-09-29
摘要： This invention relates to new polypeptide compounds represented by formula (I), wherein R1 is as defined in the description and pharmaceutically acceptable salt thereof which have antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
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公开(公告)号：EP0674645B1
公开(公告)日：1997-07-16
申请号：EP94903000.1
申请日：1993-12-15
发明人： TAKAYA, Takao , SAKANE, Kazuo , MIYAI, Kenzi , KAWABATA, Kohji , OKUDA, Shinya , OHKI, Hidenori , YAMANAKA, Hideaki
IPC分类号： C07D501/48 , A61K31/545
CPC分类号： C07D501/00
摘要： This invention relates to a compound of formula (I) and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a method for preventing and/or treating infectious diseases in human beings and animals. In said formula (I), R1 is amino or protected amino, R2 is ethyl, propyl, cyclo(lower)alkyl, 1-methylpropenyl or 2-methylpropenyl, R3 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, and R4 is amino or protected amino.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其制备方法，含有该化合物的药物组合物，以及预防和/或治疗人和动物传染病的方法。 在所述式（I）中，R1是氨基或被保护的氨基，R2是乙基，丙基，环（低级）烷基，1-甲基丙烯基或2-甲基丙烯基，R3是羟基（低级）烷基或被保护的羟基 R4是氨基或被保护的氨基。
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