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公开(公告)号：EP2662447B1
公开(公告)日：2020-02-05
申请号：EP12167377.6
申请日：2012-05-09
发明人： MÜLLER, Boje , PRÜFER, Dirk , FISCHER, Rainer
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2.发明公开
公开(公告)号：EP3579845A1
公开(公告)日：2019-12-18
申请号：EP18751568.9
申请日：2018-02-09
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3.发明公开SPECIFIC PHOTOIMMUNO-THERANOSTICS FOR DETECTION AND ELIMINATION OF SKIN CANCER CELLS 审中-公开用于检测和消除皮肤癌细胞的特异性光学免疫 - 药物学
公开(公告)号：EP3310387A1
公开(公告)日：2018-04-25
申请号：EP15730742.2
申请日：2015-06-16
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. , Rheinisch-Westfälische Technische Hochschule Aachen
CPC分类号： A61K41/0071 , A61K41/0061 , A61K47/64 , A61K47/6849
摘要： The technology provided herein generally relates to novel specific photoimmuno-theranostics for the use in detection and elimination of skin cancer cells. The technology also relates to novel methods which generate homogeneous and specific photoimmuno-theranostics reagents in a simple, controlled and efficient way. This method combines molecular optical imaging, photodynamic therapy and immunotherapy using SNAP-tag technology.
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公开(公告)号：EP3185906A1
公开(公告)日：2017-07-05
申请号：EP15753943.8
申请日：2015-08-21
CPC分类号： C07K16/205 , A61K47/6815 , A61K47/6835 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C12N9/6467 , C12Y304/21079
摘要： The technology provided herein relates to novel anti-parasitic complexes, in particular recombinant fusion proteins suitable as human and/or animal drugs against a parasite of the phylum Apicomplexa, in particular against Plasmodium falciparum ( P. falciparum ) comprising at least one component A and at least one component B, characterized in that component A has a binding activity for cellular surface structures presented on the surface of a parasite of the phylum Apicomplexa or for parasitic antigens presented on a parasitized host cell, and component B is a compound having anti-parasitic activity.
摘要翻译： 本文提供的技术涉及新颖的抗寄生虫复合物，特别是适合作为抗人类和/或动物药物的抗重组融合蛋白，所述药物抵抗门Apicomplexa的寄生虫，特别是针对包含至少一种组分A的恶性疟原虫（P.falciparum）和 至少一种组分B，其特征在于组分A对细胞表面结构具有结合活性，所述细胞表面结构呈现在复盖门的寄生虫表面上或呈现于寄生宿主细胞上的寄生虫抗原，组分B是具有抗 - 寄生活动。
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公开(公告)号：EP3164151A1
公开(公告)日：2017-05-10
申请号：EP15734655.2
申请日：2015-07-03
CPC分类号： A61K38/57 , A01N43/16 , A01N63/02 , A61K31/7036 , A61K45/06 , A61K48/00 , A61L2/16 , A61L2202/21 , C07K14/8146 , A61K2300/00
摘要： A composition comprising as components a polypeptide IMPIα (including wild type) and/or a polypeptide IMPIα-fusion and at least one antibiotic compound, in particular an aminoglycoside antibiotic, and/or at least one bactericidal compound, wherein the polypeptides, the at least one antibiotic and the at least one bactericidal compound is present in the composition in concentrations which exhibit in combination a synergistic effect against resistant bacteria.
摘要翻译： 包含多肽IMPIα（包括野生型）和/或多肽IMPIα-融合物和至少一种抗生素化合物，特别是氨基糖苷类抗生素和/或至少一种杀菌化合物作为组分的组合物，其中所述多肽，至少 一种抗生素和至少一种杀菌化合物在组合物中以组合显示对抗性细菌的协同作用的浓度存在。
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公开(公告)号：EP2879706A1
公开(公告)日：2015-06-10
申请号：EP13748000.0
申请日：2013-07-31
发明人： FENDEL, Rolf , KLOCKENBRING, Torsten , BARTH, Stefan , KAPELSKI, Stephanie , MASKUS, Dominika , FISCHER, Rainer , REIMANN, Andreas
IPC分类号： A61K39/395 , A61P33/06 , C07K16/20
CPC分类号： C07K16/205 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： The technology provided herein relates to novel human antibodies against
Plasmodium parasites, in particular against the malaria parasite
Plasmodium falciparum . The present disclosure pertains to antibodies against merozoite surface protein 10 (MSP10). These antibodies have high affinity e.g. to
Plasmodium falciparum schizonts and merozoites, inhibit the reinvasion of merozoites into erythrocytes and thereby neutralize parasitic multiplication.摘要翻译： 本文提供的技术涉及针对疟原虫寄生虫的新型人抗体，特别是针对疟疾寄生虫恶性疟原虫。 本公开涉及针对裂殖子表面蛋白10（MSP10）的抗体。 这些抗体具有高亲和力，例如 到恶性疟原虫裂殖体和裂殖子，抑制裂殖子进入红细胞，从而中和寄生虫繁殖。
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7.发明公开METHOD FOR THE GENERATION OF A MONOCLONAL PLANT CELL LINE 审中-公开VERFAHREN ZUR ERZEUGUNG EINER MONOKLONALEN PFLANZENZELLLINIE
公开(公告)号：EP2717676A1
公开(公告)日：2014-04-16
申请号：EP11729369.6
申请日：2011-06-07
发明人： KIRCHHOFF, Janina , SCHILLBERG, Stefan , SCHIERMEYER, Andreas , SCHINKEL, Helga , FISCHER, Rainer
IPC分类号： A01H4/00
CPC分类号： C12N15/8241 , A01H4/005
摘要： The invention provides a method for the generation of a monoclonal plant cell line from a heterologous population of plant cells, comprising the following steps: (a) provision of a heterologous population of plant cells; (b) preparation of protoplasts from said heterologous population of plant cells; (c) separation of single protoplasts by subjecting the preparation of protoplasts to flow cytometric sorting; (d) regeneration of a separated single transformed protoplast until the formation of a microcolony by co-cultivation in the presence of feeder cell material; (e) removal of the microcolony from the feeder cell material and cultivation of the microcolony until the formation of a monoclonal plant cell line.
摘要翻译： 本发明提供从异源植物细胞群体产生单克隆植物细胞系的方法，包括以下步骤：（a）提供异源植物细胞群; （b）从所述异源植物细胞群体制备原生质体; （c）通过使原生质体的制备物流式细胞分选来分离单个原生质体; （d）分离的单一转化的原生质体的再生直到在饲养细胞材料存在下共培养形成微菌落; （e）从饲养细胞材料中除去微菌落并培养微菌落直到形成单克隆植物细胞系。
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8.发明授权A DIABODY WHICH SPECIFICALLY BINDS STREPTOCOCCUS SURFACE ANTIGEN I/II AND METHODS OF USE THEREOF 有权具体到链球菌表面抗原I / II结合使用双功能抗体和方法
公开(公告)号：EP1749030B1
公开(公告)日：2011-06-15
申请号：EP05742967.2
申请日：2005-04-21
发明人： FINNERN, Ricarda , FISCHER, Rainer
CPC分类号： C07K16/1275 , C07K2317/21 , C07K2317/622 , C07K2317/626
摘要： Common oral diseases such as periodontitis and dental caries can be prevented effectively by passive immunization. The present invention provides human single chain Fv (scFv) and diabody antibody fragments based on the binding characteristics of the murine monoclonal antibody Guy's 13. Like the parent antibody, these derivatives bind specifically to SAI/II, the surface adhesin of Streptococcus and the human diabody derivative is capable of aggregating streptococcal cells, making it a useful candidate therapeutic agent for passive immunization against oral diseases.
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公开(公告)号：EP4234704A3
公开(公告)日：2024-01-03
申请号：EP23169866.3
申请日：2013-10-22
申请人： SEKISUI CHEMICAL CO., LTD. , Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
摘要： To provide a series of techniques capable of producing isoprene from syngas or the like.
Provided is a recombinant cell prepared by introducing a nucleic acid encoding isoprene synthase into a host cell having an isopentenyl diphosphate synthesis ability by a non-mevalonate pathway, wherein the nucleic acid is expressed in the host cell, and the recombinant cell is capable of producing isoprene from at least one C1 compound selected from the group consisting of carbon monoxide, carbon dioxide, formic acid, and methanol. As the host cell, a Clostridium bacterium or a Moorella bacterium is exemplified. Also provided is a method for producing isoprene using the recombinant cell.-
公开(公告)号：EP2717676B1
公开(公告)日：2019-01-02
申请号：EP11729369.6
申请日：2011-06-07
发明人： KIRCHHOFF, Janina , SCHILLBERG, Stefan , SCHIERMEYER, Andreas , SCHINKEL, Helga , FISCHER, Rainer
IPC分类号： A01H4/00
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