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1.发明公开HETEROCYCLIC GLYCYL BETA-ALANINE DERIVATIVES AS VITRONECTIN ANTAGONISTS 审中-公开杂环甘氨酰基β-丙氨酸衍生物作为玻连蛋白antagoniste
公开(公告)号：EP1070060A1
公开(公告)日：2001-01-24
申请号：EP99916119.3
申请日：1999-04-09
申请人： G.D. Searle & Co.
发明人： CHANDRAKUMAR, Nizal, Samuel , DESAI, Bipinchandra, Nanubhai , DEVADAS, Balekudru , HUFF, Renee , KHANNA, Ish, K. , RAO, Shashidhar, N. , RICO, Joseph, G. , ROGERS, Thomas, E. , RUMINSKI, Peter, G. , RUSSELL, Mark, Andrew , YU, Yi , GASIECKI, Alan, Frank , MALECHA, James, W. , MIYASHIRO, Julie, M.
IPC分类号： C07D401/12 , A61K31/44 , C07K5/023 , C07D213/82 , C07D495/10 , C07D409/12 , C07D333/38 , C07D403/12 , C07D417/12
CPC分类号： C07D213/82 , A61K38/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07D491/10 , C07K5/0202
摘要： The present invention relates to a class of compounds represented by formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and methods of treating conditions mediated by the αvβ3 integrin.
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2.发明公开PLATELET AGGREGATION INHIBITORS CONTAINING C-TERMINAL AMINERGIC SIDE CHAIN AMINO ACID RESIDUES 失效血小板聚集的抑制剂，WITH胺能侧链中的C末端氨基酸残基。包含
公开(公告)号：EP0835265A1
公开(公告)日：1998-04-15
申请号：EP96909731.0
申请日：1996-03-22
申请人： G.D. SEARLE & CO.
发明人： ABOOD, Norman, A. , BOVY, Philippe, R. , FLYNN, Daniel, L. , RICO, Joseph, G. , ROGERS, Thomas, E.
CPC分类号： C07K5/021 , A61K38/00 , C07K5/0202 , C07K5/06113
摘要： This invention relates to compounds having formula (I) or pharmaceutically acceptable salts thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions containing such compounds, and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.
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3.发明授权
公开(公告)号：EP0891325B1
公开(公告)日：2002-02-06
申请号：EP97916852.3
申请日：1997-03-26
申请人： G.D. SEARLE & CO.
发明人： CHEN, Barbara, B. , CHEN, Helen, Y. , GESICKI, Glen, J. , HAACK, Richard, A. , MALECHA, James, W. , PENNING, Thomas, D. , RICO, Joseph, G. , ROGERS, Thomas, E. , RUMINSKI, Peter, G. , RUSSELL, Mark, A. , YU, Stella, S.
IPC分类号： C07C279/18 , A61K31/155 , C07D223/04 , C07C311/06 , C07C259/18 , C07C257/18 , C07C275/42 , C07C311/19 , C07C311/47 , C07D233/88 , C07C279/28
CPC分类号： C07D271/07 , A61K31/155 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07C279/28 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/64 , C07C317/44 , C07C323/52 , C07D223/12 , C07D231/12 , C07D233/50 , C07D233/56 , C07D233/88 , C07D239/14 , C07D249/08 , C07D249/14 , C07D295/215
摘要： The present invention relates to a class of compounds represented by Formula (I) or a phramaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of Formula (I), and methods of selectively inhibiting or antagonizing the αvβ3 integrin.
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4.发明公开META-AZACYCLIC AMINO BENZOIC ACID COMPOUNDS AND DERIVATIVES THEREOF BEING INTEGRIN ANTAGONISTS 审中-公开与整合ANTAGONISCHER影响META AZACYKLISCHE氨基苯甲酸衍生物
公开(公告)号：EP1060164A1
公开(公告)日：2000-12-20
申请号：EP99937927.4
申请日：1999-02-22
申请人： G.D. SEARLE & CO.
IPC分类号： C07D233/26 , A61K31/505
CPC分类号： A61K31/704 , A61K31/505 , A61K31/675 , C07D239/14 , A61K2300/00
摘要： The present invention is directed to compounds of formula (1) and pharmaceutically acceptable salts and isomers thereof useful as αvβ3 integrin antagonists.
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5.发明授权PLATELET AGGREGATION INHIBITORS CONTAINING C-TERMINAL AMINERGIC SIDE CHAIN AMINO ACID RESIDUES 失效血小板聚集的抑制剂，WITH胺能侧链的C-末端的氨基酸残基。包含
公开(公告)号：EP0835265B1
公开(公告)日：2002-08-07
申请号：EP96909731.0
申请日：1996-03-22
申请人： G.D. SEARLE & CO.
发明人： ABOOD, Norman, A. , BOVY, Philippe, R. , FLYNN, Daniel, L. , RICO, Joseph, G. , ROGERS, Thomas, E.
CPC分类号： C07K5/021 , A61K38/00 , C07K5/0202 , C07K5/06113
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6.发明公开USE OF AN INTEGRIN ANTAGONIST AND A CHEMOTHERAPEUTIC AGENT IN THE TREATMENT OF NEOPLASIA 审中-公开甲整连同CHEMO治疗剂在治疗肿瘤的用途
公开(公告)号：EP1161280A1
公开(公告)日：2001-12-12
申请号：EP00914580.6
申请日：2000-03-01
申请人： G.D. Searle & Co.
发明人： CUNNINGHAM, Jay , GORDON, Gary, B. , NICKOLS, G., Allen , WESTLIN, William, F. , ROGERS, Thomas, E. , RUMINSKI, Peter, G.
IPC分类号： A61P35/00 , A61K31/505 , A61K33/24 , A61K31/675 , A61K31/704 , A61K31/335
CPC分类号： A61K31/704 , A61K31/505 , A61K31/675 , A61K33/24 , C07D239/14 , A61K31/70 , A61K31/335 , A61K2300/00
摘要： The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts and isomers thereof administered in combination with chemotherapeutic agents.
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7.发明公开
公开(公告)号：EP0891325A1
公开(公告)日：1999-01-20
申请号：EP97916852.0
申请日：1997-03-26
申请人： G.D. SEARLE & CO.
发明人： CHEN, Barbara, B. , CHEN, Helen, Y. , GESICKI, Glen, J. , HAACK, Richard, A. , MALECHA, James, W. , PENNING, Thomas, D. , RICO, Joseph, G. , ROGERS, Thomas, E. , RUMINSKI, Peter, G. , RUSSELL, Mark, A. , YU, Stella, S.
IPC分类号： A61K31 , A61P9 , A61P19 , A61P27 , A61P35 , C07C257 , C07C259 , C07C275 , C07C279 , C07C311 , C07C317 , C07C323 , C07D223 , C07D233 , C07D239 , C07D249 , C07D271 , C07D295 , C07D521
CPC分类号： C07D271/07 , A61K31/155 , C07C275/42 , C07C279/18 , C07C279/22 , C07C279/24 , C07C279/28 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/64 , C07C317/44 , C07C323/52 , C07D223/12 , C07D231/12 , C07D233/50 , C07D233/56 , C07D233/88 , C07D239/14 , C07D249/08 , C07D249/14 , C07D295/215
摘要： The present invention relates to a class of compounds represented by Formula (I) or a phramaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of Formula (I), and methods of selectively inhibiting or antagonizing the αvβ3 integrin.
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