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公开(公告)号：EP1144373B1
公开(公告)日：2005-10-19
申请号：EP00911572.6
申请日：2000-01-11
申请人： GENENTECH, INC.
发明人： ALIAGAS-MARTIN, Ignacio , ARTIS, Dean, R. , DINA, Michael, S. , FLYGARE, John, A. , GOLDSMITH, Richard, A. , MUNROE, Regina, A. , OLIVERO, Alan, G. , PASTOR, Richard , RAWSON, Thomas, E. , ROBARGE, Kirk, D. , SUTHERLIN, Daniel, P. , WEESE, Kenneth, J. , ZHOU, Aihe , ZHU, Yan
IPC分类号： C07C311/51
CPC分类号： C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要： Compounds having structure (A) are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
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公开(公告)号：EP1968581A2
公开(公告)日：2008-09-17
申请号：EP06850957.9
申请日：2006-12-14
申请人： Genentech, Inc.
IPC分类号： A61K31/4162 , C07D487/02
CPC分类号： C07D497/16
摘要： The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula (I): I wherein X, Y, Z, R1, R2, R3, Ra, Rb, and n are as described herein.
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公开(公告)号：EP1144373A2
公开(公告)日：2001-10-17
申请号：EP00911572.6
申请日：2000-01-11
申请人： Genentech, Inc.
发明人： ALIAGAS-MARTIN, Ignacio , ARTIS, Dean, R. , DINA, Michael, S. , FLYGARE, John, A. , GOLDSMITH, Richard, A. , MUNROE, Regina, A. , OLIVERO, Alan, G. , PASTOR, Richard , RAWSON, Thomas, E. , ROBARGE, Kirk, D. , SUTHERLIN, Daniel, P. , WEESE, Kenneth, J. , ZHOU, Aihe , ZHU, Yan
IPC分类号： C07C317/00
CPC分类号： C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要： Compounds having structure (A) are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
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公开(公告)号：EP1919920B1
公开(公告)日：2011-05-18
申请号：EP06813425.3
申请日：2006-08-14
发明人： RAWSON, Thomas, E. , SAFINA, Brian , DOTSON, Jennafer , ALIAGAS-MARTIN, Ignacio , HALLADAY, Jason , LIANG, Jun , RUETH, Matthias , ZHU, Bing-Yan , BROOKFIELD, Frederick , PRIME, Michael , ZHANG, Birong , LI, Jun, M. , Zhou, Aihe
IPC分类号： C07D487/04 , C07D491/04 , A61K31/4155 , A61P35/00
CPC分类号： C07D487/04 , C07D491/04
摘要： The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula: (I) wherein A, X, Y, Z, Ra, Rb, Rc, R1 , R2, R3 and m are defined herein.
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公开(公告)号：EP1144373A3
公开(公告)日：2002-01-02
申请号：EP00911572.6
申请日：2000-01-11
申请人： Genentech, Inc.
发明人： ALIAGAS-MARTIN, Ignacio , ARTIS, Dean, R. , DINA, Michael, S. , FLYGARE, John, A. , GOLDSMITH, Richard, A. , MUNROE, Regina, A. , OLIVERO, Alan, G. , PASTOR, Richard , RAWSON, Thomas, E. , ROBARGE, Kirk, D. , SUTHERLIN, Daniel, P. , WEESE, Kenneth, J. , ZHOU, Aihe , ZHU, Yan
IPC分类号： C07C311/51
CPC分类号： C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
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公开(公告)号：EP1919920A2
公开(公告)日：2008-05-14
申请号：EP06813425.3
申请日：2006-08-14
发明人： RAWSON, Thomas, E. , SAFINA, Brian , DOTSON, Jennafer , ALIAGAS-MARTIN, Ignacio , HALLADAY, Jason , LIANG, Jun , RUETH, Matthias , ZHU, Bing-Yan , BROOKFIELD, Frederick , PRIME, Michael , ZHANG, Birong , LI, Jun, M. , Zhou, Aihe.
IPC分类号： C07D487/04 , C07D491/04 , A61K31/4155 , A61P35/00
CPC分类号： C07D487/04 , C07D491/04
摘要： The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula: (I) wherein A, X, Y, Z, Ra, Rb, Rc, R1 , R2, R3 and m are defined herein.
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