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公开(公告)号：EP3360567A1
公开(公告)日：2018-08-15
申请号：EP17208162.2
申请日：2008-11-07
申请人： Genentech, Inc.
发明人： ABBAS, Alexander, R. , DANILENKO, Dimitry, M. , DE SAUVAGE, Frederic, J. , GHILARDI, Nico, P. , MODRUSAN, Zora , OUYANG, Wenjun , VALDEZ, Patricia, A. , ZHENG, Yan
CPC分类号： A61K38/191 , A61K38/1709 , A61K38/20 , A61K38/204 , Y02A50/473
摘要： The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.
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公开(公告)号：EP3006466B1
公开(公告)日：2018-08-01
申请号：EP15176159.0
申请日：2006-11-30
申请人： Genentech, Inc.
发明人： CHEN, Yvonne , CHUNTHARAPAI, Anan , DANILENKO, Dimitry , OUYANG, Wenjun , SA, Susan , VALDEZ, Patricia , WONG, Terence , WU, Jianfeng , ZHENG, Yan
CPC分类号： A61K39/3955 , A61K38/17 , A61K38/1793 , A61K38/20 , A61K2039/505 , A61K2039/57 , C07K16/244 , C07K16/2866 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.
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公开(公告)号：EP2217263A2
公开(公告)日：2010-08-18
申请号：EP08848478.7
申请日：2008-11-07
申请人： Genentech, Inc.
发明人： ABBAS, Alexander, R. , DANILENKO, Dimitry, M. , DE SAUVAGE, Frederic, J. , GHILARDI, Nico, P. , MODRUSAN, Zora , OUYANG, Wenjun , VALDEZ, Patricia, A. , ZHENG, Yan
CPC分类号： A61K38/191 , A61K38/1709 , A61K38/20 , A61K38/204 , Y02A50/473
摘要： The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.
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4.发明公开
公开(公告)号：EP2056860A2
公开(公告)日：2009-05-13
申请号：EP07864668.4
申请日：2007-11-20
申请人： Genentech, Inc.
发明人： GURNEY, Austin L. , BALAZS, Mercedes , GHILARDI, Nico , HYMOWITZ, Sarah , HASS, Philip , STAROVASNIK, Melissa , WU, Yan , LEE, James M. , ARNOTT, David , OUYANG, Wenjun
CPC分类号： C07K16/244 , A61K38/2073 , A61K2039/505 , C07K14/54 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/40 , G01N2500/10 , G01N2800/24 , Y02A50/463
摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17 A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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5.发明公开COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH CYTOKINE SIGNALING INVOLVING ANTIBODIES THAT BIND TO IL-22 AND IL-22R 审中-公开用于治疗与细胞因子信号相关的疾病和病症的组合物和方法，所述细胞因子信号涉及与IL-22和IL-22R结合的抗体
公开(公告)号：EP3006466A3
公开(公告)日：2016-07-27
申请号：EP15176159.0
申请日：2006-11-30
申请人： Genentech, Inc.
发明人： CHEN, Yvonne , CHUNTHARAPAI, Anan , DANILENKO, Dimitry , OUYANG, Wenjun , SA, Susan , VALDEZ, Patricia , WONG, Terence , WU, Jianfeng , ZHENG, Yan
CPC分类号： A61K39/3955 , A61K38/17 , A61K38/1793 , A61K38/20 , A61K2039/505 , A61K2039/57 , C07K16/244 , C07K16/2866 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.
摘要翻译： 提供了组合物和方法用于诊断和治疗炎症和自身免疫性疾病，例如牛皮癣。 提供了调节IL-23或IL-22信号的组合物和方法。
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6.发明公开COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH CYTOKINE SIGNALING INVOLVING ANTIBODIES THAT BIND TO IL-22 AND IL-22R 审中-公开组合物和方法用于疾病的治疗和遭受与细胞因子SIGNALING CONNECTION并使用IL-22与IL-22R结合抗体
公开(公告)号：EP1954719A2
公开(公告)日：2008-08-13
申请号：EP06851192.2
申请日：2006-11-30
申请人： Genentech Inc.
发明人： CHEN, Yvonne , CHUNTHARAPAI, Anan , DANILENKO, Dimitry , OUYANG, Wenjun , SA, Susan , VALDEZ, Patricia , WONG, Terence , WU, Jianfeng , ZHENG, Yan
CPC分类号： A61K39/3955 , A61K38/17 , A61K38/1793 , A61K38/20 , A61K2039/505 , A61K2039/57 , C07K16/244 , C07K16/2866 , C07K2317/76 , C07K2317/92
摘要： Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided, including antibodies that bind to IL-22 and IL-22R.
摘要翻译： 提供用于炎症和自身免疫病症，：如牛皮癣的诊断和治疗组合物和方法。 提供了组合物和用于调制IL-23或IL-22信号传导的方法。
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公开(公告)号：EP3181147A1
公开(公告)日：2017-06-21
申请号：EP16197439.9
申请日：2007-11-20
申请人： Genentech, Inc.
发明人： GURNEY, Austin, L , BALAZS, Mercedesz , GHILARDI, Nico , HYMOWITZ, Sarah , HASS, Philip, E , STAROVASNIK, Melissa, A , WU, Yan , LEE, James, M , ARNOTT, David, P , OUYANG, Wenjun
CPC分类号： C07K16/244 , A61K38/2073 , A61K2039/505 , C07K14/54 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/40 , G01N2500/10 , G01N2800/24 , Y02A50/463
摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17 A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译： 本发明涉及一种新的天然存在的人细胞因子，其由白介素17和白细胞介素17F的异二聚体组成，在本文中称为白细胞介素17A / F（IL-17A / F）。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的特异性抗体以及用于产生本发明多肽的方法 本发明。 本文进一步提供了用于治疗退行性软骨病症和其他炎性疾病的方法。
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8.发明公开
公开(公告)号：EP1812465A1
公开(公告)日：2007-08-01
申请号：EP04822633.6
申请日：2004-11-12
申请人： Genentech, Inc.
发明人： CLARK, Hilary , EATON, Daniel L. , WRANIK, Bernd , OUYANG, Wenjun , GONZALEZ, Lino , LOYET, Kelly M.
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505 , C07K16/2818 , C12N2799/026
摘要： The present invention relates to compositions comprising a novel protein and methods for using the same for the diagnosis and treatment of immune-related diseases.
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9.发明公开
公开(公告)号：EP1694116A2
公开(公告)日：2006-08-30
申请号：EP04813966.1
申请日：2004-12-13
发明人： ANDERSON, Stephen , BRENNAN, Jane , DESAUVAGE, Frederic , DING, Zhiyong , EDWARDS, Joel , FIKES, Nelda , HUANG, Wenhu , OUYANG, Wenjun , RANGEL, Carolina , SANGHA, Mamta , SHI, Zheng-Zheng , SPARKS, Mary Jean , TRACKEY, Joseph , VETTER, Melissa , WANG, Ching-Yun , WOODINGS, Jessica
IPC分类号： A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0306
摘要： The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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公开(公告)号：EP1618132A2
公开(公告)日：2006-01-25
申请号：EP04750052.5
申请日：2004-04-08
申请人： GENENTECH, INC.
发明人： BALDWIN, Daryl , CLARK, Hilary , CHIU, Henry , FEDOROWICZ, Grazyna , FONG, Sherman , GRIMALDI, J., Christopher , OUYANG, Wenjun , WILLIAMS, P. Mickey
IPC分类号： C07K14/47
CPC分类号： G01N33/56972 , C07K14/47 , G01N33/6863 , G01N2500/00 , G01N2800/24 , Y02A50/55
摘要： The present invention relates to compositions of matter and methods for the treatment and diagnosis of immune related diseases, including those mediated by cytokines released primarily either Th1 or Th2 cells in response to antigenic stimulation. The present invention further relates to methods for biasing the differentiation of T-cells in either the Th1 subtype or the Th2 subtype based on the relative expression levels of the gene PRO92726, and its agonists or antagonists. The present invention further relates to a method of diagnosing Th1- and Th2-mediated diseases.
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