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公开(公告)号:EP1196566A1
公开(公告)日:2002-04-17
申请号:EP00945309.3
申请日:2000-07-11
申请人: Genentech, Inc.
IPC分类号: C12N15/12 , C12N15/10 , C12N15/62 , C12N15/65 , C12N15/69 , C12N15/85 , C07K14/435 , C07K14/71 , C07K16/42 , C12Q1/68
CPC分类号: C12N15/85 , C07K14/43595 , C07K14/71 , C07K16/4291 , C07K2319/00 , C12N15/65 , C12N15/69 , C12N2800/108 , C12N2830/42 , C12N2830/46 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44
摘要: Vectors and methods for efficient isolation of recombinant cells expressing high levels of a desired protein are provided. The vectors comprise an amplifiable selectable gene, a fluorescent protein gene, and a gene encoding a desired product in a manner that optimizes transcriptional and translational linkage.
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2.
公开(公告)号:EP0698015A1
公开(公告)日:1996-02-28
申请号:EP94917338.0
申请日:1994-05-10
发明人: MARSTERS, James, C., Jr. , BROWN, Michael, S. , CROWLEY, Craig, W. , GOLDSTEIN, Joseph, L. , JAMES, Guy, L. , McDOWELL, Robert, S. , OARE, David , RAWSON, Thomas, E. , REYNOLDS, Mark , SOMERS, Todd, G.
IPC分类号: A61K31 , A61P31 , A61P35 , C07D223 , C07D243 , C07D401 , C07D403 , C07D405 , C07D409 , C07D417 , C07D487 , C07D498 , C07D513 , C07K5 , A61K38
CPC分类号: C07D223/16 , A61K38/00 , C07D243/10 , C07D243/24 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/06 , C07D409/14 , C07D487/04 , C07D513/04 , C07K5/0207 , C07K5/0606 , C07K5/06139 , C07K5/06191 , C07K5/081 , C07K5/0821 , C07K5/0827 , C07K5/1013 , C07K5/1024 , C07K5/1027
摘要: Benzodiazepine derivatives are disclosed that act as potent inhibitors of ras farnesyl:protein transferase. Pharmaceutical compositions containing these benzodiazepines are provided for treatment of diseases for which inhibition of the ras farnesyl:protein transferase is indicated.
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公开(公告)号:EP1196566B1
公开(公告)日:2006-02-01
申请号:EP00945309.3
申请日:2000-07-11
申请人: GENENTECH, INC.
IPC分类号: C12N15/12 , C12N15/10 , C12N15/62 , C12N15/65 , C12N15/69 , C12N15/85 , C07K14/435 , C07K14/71 , C07K16/42 , C12Q1/68
CPC分类号: C12N15/85 , C07K14/43595 , C07K14/71 , C07K16/4291 , C07K2319/00 , C12N15/65 , C12N15/69 , C12N2800/108 , C12N2830/42 , C12N2830/46 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44
摘要: Vectors and methods for efficient isolation of recombinant cells expressing high levels of a desired protein are provided. The vectors comprise an amplifiable selectable gene, a fluorescent protein gene, and a gene encoding a desired product in a manner that optimizes transcriptional and translational linkage.
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4.
公开(公告)号:EP2289936B1
公开(公告)日:2017-05-31
申请号:EP10179942.7
申请日:2003-12-16
申请人: Genentech, Inc.
发明人: ADAMS, Camellia, W. , CHAN, Andrew, C. , CROWLEY, Craig, W. , LOWMAN, Henry, B. , NAKAMURA, Gerald, R. , PRESTA, Leonard, G.
IPC分类号: C07K16/00 , A61K39/395 , C12N15/63
CPC分类号: C07K16/2887 , A61K2039/505 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92
摘要: The invention provides humanized and chimeric anti-CD20 antibodies for treatment of CD20 positive malignancies and autoimmune diseases.
摘要翻译: 本发明提供用于治疗CD20阳性恶性肿瘤和自身免疫疾病的人源化和嵌合抗CD20抗体。
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