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公开(公告)号：EP2855669A1
公开(公告)日：2015-04-08
申请号：EP13729157.1
申请日：2013-05-28
申请人： GenVec, Inc.
发明人： WEI, Lisa , BROUGH, Douglas E. , KING, C. Richter
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0008 , C12N2710/10021 , C12N2710/10043 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/16634 , C12N2810/6018
摘要： The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
摘要翻译： 本发明提供了复制缺陷型血清型28腺病毒载体，其特征在于包含一部分血清型45腺病毒六邻体蛋白和/或血清型45纤维蛋白的一部分代替内源性血清型28六邻体和/或纤维蛋白。
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公开(公告)号：EP1740218A1
公开(公告)日：2007-01-10
申请号：EP05725429.4
申请日：2005-03-11
申请人： GENVEC, INC.
发明人： WEI, Lisa , RASMUSSEN, Henrik, S.
IPC分类号： A61K48/00 , C12N15/861 , A61P27/02
CPC分类号： C12N15/86 , A61K9/0051 , A61K38/1709 , A61K38/57 , A61K48/00 , A61K48/005 , C12N2710/10343
摘要： The invention is directed to a method of prophylactically or therapeutically treating an animal for vascular leakage in an eye. The method comprises administering to an animal in need thereof an expression vector comprising a nucleic acid sequence encoding pigment epithelium-derived factor (PEDF) such that vascular leakage in the eye of the animal is treated prophylactically or therapeutically. The invention also provides a method of prophylactically or therapeutically treating an animal for vascular leakage in an eye. The method comprises periocularly administering to an animal in need thereof PEDF such that vascular leakage of the animal is treated prophylactically or therapeutically. The invention also provides a method of prophylactically or therapeutically treating an animal for non-diabetic vascular leakage in an eye. The method comprises administering to an animal in need thereof PEDF such that non-diabetic vascular leakage in the eye is treated prophylactically or therapeutically.
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公开(公告)号：EP1253948A2
公开(公告)日：2002-11-06
申请号：EP01909022.4
申请日：2001-02-09
申请人： GENVEC, INC.
IPC分类号： A61K48/00
CPC分类号： A61K48/0075 , A61K48/005 , C07K14/71 , C07K14/811 , C12N15/86 , C12N2710/10343
摘要： The present invention is directed to a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder, e.g., ocular neovascularization or age-related macular degeneration. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and the same or different nucleic acid sequence encoding a neurotrophic agent. The method also can comprise contacting an ocular cell with different expression vectors, each comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a nucleic acid sequence encoding a neurotrophic agent. In addition, the present invention provides a viral vector comprising a nucleic acid sequence encoding pigment epithelium-derived factor (PEDF) or a therapeutic fragment thereof.
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公开(公告)号：EP2855511B1
公开(公告)日：2019-07-24
申请号：EP13725523.8
申请日：2013-05-16
申请人： GenVec, Inc.
IPC分类号： C07K14/035 , A61K39/245 , C12N15/861
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公开(公告)号：EP2855669B1
公开(公告)日：2018-10-10
申请号：EP13729157.1
申请日：2013-05-28
申请人： GenVec, Inc.
发明人： WEI, Lisa , BROUGH, Douglas E. , KING, C. Richter
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0008 , C12N2710/10021 , C12N2710/10043 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/16634 , C12N2810/6018
摘要： The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
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公开(公告)号：EP2855511A1
公开(公告)日：2015-04-08
申请号：EP13725523.8
申请日：2013-05-16
申请人： GenVec, Inc.
IPC分类号： C07K14/035 , A61K39/245 , C12N15/861
CPC分类号： C07K14/005 , A61K39/12 , A61K39/245 , A61K2039/53 , A61K2039/545 , C12N7/00 , C12N2710/10043 , C12N2710/16622 , C12N2710/16634 , C12N2799/022 , C12N2800/22
摘要： Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.
摘要翻译： 提供了引起HSV特异性免疫应答并可用于治疗或预防HSV感染的单纯疱疹病毒（HSV）抗原。 还提供了核酸序列，多肽，载体和组合物，以及诱导针对HSV的免疫应答，治疗或预防HSV疾病，诱导针对HSV的T细胞应答以及诱导针对HSV的抗体应答的方法。
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公开(公告)号：EP1567198A2
公开(公告)日：2005-08-31
申请号：EP03812479.8
申请日：2003-12-01
申请人： GenVec, Inc.
IPC分类号： A61K48/00 , C12N15/85 , C12N15/86 , C12N15/861
CPC分类号： A61K48/005 , A61K9/0048 , A61K31/203 , A61K31/7088 , A61K38/57 , A61K45/06 , A61K48/00 , A61K48/0058 , A61K48/0075 , A61K48/0083 , C12N15/86 , C12N2710/10343 , C12N2799/022 , A61K2300/00
摘要： The invention is directed to a method of delivering a gene product to an animal. The method comprises administering an expression vector comprising a nucleic acid sequence operably linked to a promoter and encoding a gene product, and upregulating transcription of the nucleic acid sequence in the ocular cell. The expression vector can be an adenoviral vector. The invention further provides a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a neurotrophic agent. In one aspect, the method further comprises upregulating transcription of the nucleic acid sequence. Preferably, if 2x108 adenoviral particles of the inventive method are administered to a mouse, the level of expression of the nucleic acid sequence is not diminished more than tenfold at 28 days post-administration.
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