公开(公告)号：EP2370455B1

公开(公告)日：2019-07-03

申请号：EP09829477.0

申请日：2009-11-24

申请人： Government of the United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： NABEL, Gary, J. ,  AKAHATA, Wataru ,  RAO, Srinivas, S.

IPC分类号： C07K14/005 ,  C12N15/33 ,  C12N15/63 ,  A61K39/12 ,  A61P31/12 ,  C12N7/04 ,  C12N7/00

公开(公告)号：EP1784416B1

公开(公告)日：2011-10-05

申请号：EP05791578.7

申请日：2005-07-15

申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  GENVEC, INC.

发明人： NABEL, Gary, J. ,  HUANG, Yue ,  XU, Ling ,  CHAKRABARTI, Bimal ,  WU, Lan, VRC/NIAID/NIH ,  YANG, Zhi-yong ,  GALL, Jason, G., D. ,  King, C., Richter

IPC分类号： C07K14/16 ,  A61K39/21 ,  A61P31/00

CPC分类号： A61K39/21 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/70 ,  C07K14/005 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16171 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16271 ,  C12N2740/16322 ,  C12N2740/16334 ,  C12N2740/16371

摘要： The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.

公开(公告)号：EP1675613A2

公开(公告)日：2006-07-05

申请号：EP04809757.0

申请日：2004-09-15

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： NABEL, Gary, J. ,  CHAKRABARTI, Bimal ,  KONG, Wing-pui ,  HUANG, Yue ,  YANG, Zhi-yong

IPC分类号： A61K39/12 ,  C07K14/16

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234

摘要： In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades fo Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.

公开(公告)号：EP1654370B1

公开(公告)日：2018-05-30

申请号：EP04779743.6

申请日：2004-08-02

申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： NABEL, Gary, J. ,  SULLIVAN, Nancy, J. ,  GEISBERT, Thomas, W. ,  JAHRLING, Peter, B.

IPC分类号： C12N15/861 ,  A61K39/12 ,  C12N15/86

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  C07K16/1081 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2760/14134 ,  C12N2760/14171 ,  Y02A50/464

摘要： The present invention relates to genetic vaccines for stimulating cellular and humoral immune responses in humans and other hosts, and, in particular, relates to recombinant viruses that express heterologous antigens of pathogenic viruses, in single dose form.

公开(公告)号：EP1784416A2

公开(公告)日：2007-05-16

申请号：EP05791578.7

申请日：2005-07-15

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  GENVEC, INC.

发明人： NABEL, Gary, J. ,  HUANG, Yue ,  XU, Ling ,  CHAKRABARTI, Bimal ,  Wu, Lan ,  YANG, Zhi-yong ,  GALL, Jason, G., D. ,  King, C., Richter

IPC分类号： C07K14/16 ,  A61K39/21 ,  A61P31/00

CPC分类号： A61K39/21 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57 ,  A61K2039/70 ,  C07K14/005 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16171 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16271 ,  C12N2740/16322 ,  C12N2740/16334 ,  C12N2740/16371

摘要： The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.

公开(公告)号：EP1802762A2

公开(公告)日：2007-07-04

申请号：EP05812347.2

申请日：2005-10-17

申请人： GENVEC, INC. ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： KING, C., Richter ,  GALL, Jason, G., D. ,  NABEL, Gary, J. ,  CHENG, Cheng

IPC分类号： C12N15/86

CPC分类号： A61K39/0011 ,  A61K39/385 ,  A61K47/64 ,  A61K47/646 ,  A61K2039/53 ,  A61K2039/6075 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/10322 ,  Y02A50/386 ,  Y02A50/412

摘要： The invention provides a gene transfer vector and a conjugate comprising at least three contiguous amino acids of a shaft region of a subgroup C adenovirus fiber protein. The invention also provides methods of using the gene transfer vector and the conjugate to induce an immune response in a mammal, and to deliver a protein or a non-proteinaceous molecule to a specific cell type.

公开(公告)号：EP1675613B1

公开(公告)日：2012-05-23

申请号：EP04809757.0

申请日：2004-09-15

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： NABEL, Gary, J. ,  CHAKRABARTI, Bimal ,  KONG, Wing-pui ,  HUANG, Yue ,  YANG, Zhi-yong

IPC分类号： A61K39/12 ,  C07K14/16 ,  A61K39/21

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234

摘要： In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades fo Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens.

公开(公告)号：EP1737885A2

公开(公告)日：2007-01-03

申请号：EP05778761.6

申请日：2005-04-12

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  GENVEC, INC.

发明人： NABEL, Gary, J. ,  CHENG, Cheng ,  KONG, Wing-Pui ,  GALL, Jason, G., D. ,  KING, C., Richter

IPC分类号： C07K14/16

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234

摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.

公开(公告)号：EP1311686A2

公开(公告)日：2003-05-21

申请号：EP01964108.3

申请日：2001-08-14

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  Chadrabarti, Bimal K.

发明人： NABEL, Gary, J. ,  HUANG, Yue

IPC分类号： C12N15/49 ,  C12N15/62 ,  C07K14/16 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55522 ,  A61K2039/57 ,  C07K2319/00 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322

摘要： Modified HIV Env, Gag, Pol, or Nef DNA with improved ability to elicit antibody and CTL responses to HIV antigens have been identified as prototype immunogens for the treatment and prevention of HIV infections.