公开(公告)号：EP3174976A4

公开(公告)日：2018-01-17

申请号：EP15827324

申请日：2015-08-03

申请人： GPB SCIENTIFIC LLC ,  UNIV PRINCETON ,  UNIV MARYLAND

发明人： GRISHAM MICHAEL ,  CIVIN CURT I ,  STURM JAMES C ,  AUSTIN ROBERT H ,  D'SILVA JOSEPH ,  CHEN YU

IPC分类号： C12N9/00 ,  G01N30/00 ,  G01N30/50

CPC分类号： C12N9/00 ,  G01N27/447 ,  G01N30/60

摘要： Described herein are improved microfluidic devices and methods for processing cells that can improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.

公开(公告)号：EP2971287A4

公开(公告)日：2016-08-03

申请号：EP14764615

申请日：2014-03-14

申请人： GPB SCIENTIFIC LLC ,  UNIV MARYLAND ,  UNIV PRINCETON

发明人： GRISHAM MICHAEL ,  CIVIN CURT I ,  STURM JAMES C ,  AUSTIN ROBERT H ,  D SILVA JOSEPH ,  CHEN YU

IPC分类号： B01L3/00 ,  C12N5/00 ,  G01N27/447 ,  G01N30/60

CPC分类号： G01N15/1484 ,  B01L3/502753 ,  B01L3/502776 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  G01N30/6069 ,  G01N30/6095 ,  G01N2015/1481 ,  G01N2015/149 ,  G01N2015/1493

摘要： A microfluidic device comprises: a channel extending from a plurality of inlets to a plurality of outlets, wherein the channel is bounded by a first wall and a second wall opposite from the first wall; and an array of obstacles disposed within the channel configured to deflect particles in a sample comprising the particles toward the second wall when the particles are flowed from the inlets to the outlets. The particles are inputted into at least one of the plurality of inlets and are deflected through a series of parallel flow streams flowing from the plurality of inlets to the plurality of outlets while being deflected toward the second wall, wherein streams in the parallel flows comprise a reagent. Microfluidic devices and methods greatly improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.

公开(公告)号：EP2971279A4

公开(公告)日：2016-08-03

申请号：EP14763363

申请日：2014-03-14

申请人： UNIV PRINCETON ,  UNIV MARYLAND

发明人： D SILVA JOSEPH ,  AUSTIN ROBERT H ,  STURM JAMES C ,  CHEN YU ,  CIVIN CURT I

IPC分类号： B01L3/00 ,  G01N27/447 ,  G01N33/50

CPC分类号： G01N1/34 ,  A61K35/14 ,  A61K35/28 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/1894 ,  B01L2400/086 ,  G01N15/1404 ,  G01N33/5094 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1493 ,  G01N2333/70596

摘要： Described herein are devices and methods for high throughput purification of particles. In some cases, methods and devices described herein can be used to remove erythrocytes and purify leukocytes and raise the quality of umbilical cord blood and other transplant grafts, thereby significantly improving patient outcomes.

公开(公告)号：EP2826070A4

公开(公告)日：2015-11-04

申请号：EP13761284

申请日：2013-03-14

申请人： UNIV PRINCETON

发明人： AVASTHI SUSHOBHAN ,  STURM JAMES C ,  MCCLAIN WILLIAM E ,  SCHWARTZ JEFFEREY

IPC分类号： H01L31/074 ,  H01L31/18

CPC分类号： H01L31/074 ,  H01L31/02167 ,  H01L31/022475 ,  H01L31/022491 ,  H01L31/068 ,  H01L31/18 ,  Y02E10/547

公开(公告)号：EP2304414A4

公开(公告)日：2012-10-24

申请号：EP09801077

申请日：2009-07-24

申请人： UNIV PRINCETON

发明人： STURM JAMES C ,  AUSTIN ROBERT ,  LOUTHERBACK KEVIN ,  MORTON KEITH ,  PUCHALLA JASON

IPC分类号： G01N30/00 ,  G01N27/447 ,  G01N30/60

CPC分类号： B03B5/00 ,  B01L3/502753 ,  G01N27/44791 ,  G01N30/0005 ,  G01N30/6069 ,  G01N30/6095 ,  G01N2030/528

公开(公告)号：EP2994817A4

公开(公告)日：2017-01-11

申请号：EP14795467

申请日：2014-05-07

申请人： UNIV PRINCETON ,  RIEUTORT-LOUIS WARREN

发明人： RIEUTORT-LOUIS WARREN ,  HU YINGZHE ,  HUANG LIECHAO ,  SANZ-ROBINSON JOSUE ,  VERMA NAVEEN ,  WAGNER SIGURD ,  STURM JAMES C

IPC分类号： G06F3/044 ,  G06F3/041

CPC分类号： G06F3/0416 ,  G06F3/017 ,  G06F3/0346 ,  G06F3/0412 ,  G06F3/044 ,  G06F2203/04101 ,  G06F2203/04104 ,  G06F2203/04107 ,  G06F2203/04108 ,  G06F2203/04112 ,  G06K9/00201 ,  G06K9/00355 ,  G06K9/00375

公开(公告)号：EP1101244A4

公开(公告)日：2004-03-31

申请号：EP99918499

申请日：1999-04-12

申请人： UNIV PRINCETON

发明人： STURM JAMES C ,  HEBNER THOMAS R ,  PSCHENITZKA FLORIAN

IPC分类号： H05B33/10 ,  H01L27/15 ,  H01L51/00 ,  H01L51/05 ,  H01L51/30 ,  H01L51/40 ,  H01L51/50 ,  H05B33/12 ,  H01L51/20 ,  H01L21/225

CPC分类号： H01L51/5036 ,  H01L51/0003 ,  H01L51/002 ,  H01L51/0042 ,  H01L51/005

摘要： The methods of this invention involve modification of an organic film after it has been deposited by either adding new dopants into it from top or bottom surface, or by causing dopants to leave the film from its top or bottom surface. In the examples of these methods, the emitting color of light emitting diodes are modifed based on doped polymers by locally introducing dopants causing different color emission into the film by local application of a solution containing desired dopant to the film surface (by ink-jet priniting, screen printing, local droplet application, etc.). This covers the difficulties of encountered with direct patterning of three separately formed organic layers (each which uniformely coats an entire surface when formed) into regions for separate R, G, and B devices due to sensitivities of the organic materials to chemicals typically used with conventional patterning technologies. Alternatively, dopants may be introduced in an organic film (16) by diffusion from one layer (18, 19) into the film (16). Alternatively, dopants may be selectively removed form a film with solvents, etc.

公开(公告)号：EP1051738A4

公开(公告)日：2001-11-28

申请号：EP99904415

申请日：1999-01-29

申请人： UNIV PRINCETON

发明人： STURM JAMES C ,  WU CHUNG CHIH ,  MARCY DUANE ,  HEBNER THOMAS R

IPC分类号： H05B33/10 ,  H01L21/36 ,  H01L27/32 ,  H01L51/00 ,  H01L51/30 ,  H01L51/40 ,  H01L51/50 ,  H01L51/52 ,  H01L51/56 ,  H05B33/26 ,  H01L21/02

CPC分类号： H01L51/5203 ,  H01L27/3211 ,  H01L27/3244 ,  H01L27/3281 ,  H01L51/0001 ,  H01L51/0005 ,  H01L51/002 ,  H01L51/004 ,  H01L51/0042 ,  H01L51/005 ,  H01L51/0516 ,  H01L51/0541 ,  H01L51/0545 ,  H01L51/5012 ,  H01L51/56

摘要： A method of fabricating semiconductor devices using ink-jet printing is provided to directly deposit patterned polymer films (136) to create OLED's and other semiconductor devices. The luminescence of poly-vinylcarbazol (PVK) films, with dyes of coumarin 6 (C6), coumarin 47 (C47), and nile red was similar to that of films of the same composition deposited by spin-coating. Light emitting diodes with low turn-on voltages were also fabricated in PVK doped with C6 deposited by ink-jet printing.

摘要翻译： 提供了使用喷墨印刷制造半导体器件的方法，以直接沉积图案化的聚合物膜以产生OLED和其它半导体器件。 具有香豆素6（C6），香豆素47（C47）和尼罗红的染料的聚乙烯基咔唑（PVK）膜的发光与通过旋涂沉积的相同组成的膜的发光相似。 在通过喷墨打印沉积的掺杂有C6的PVK中也制造具有低导通电压的发光二极管。