-
公开(公告)号：EP3305813B1
公开(公告)日：2020-01-15
申请号：EP17189247.4
申请日：2010-11-11
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael
IPC分类号： C07K16/28 , C07K14/705 , A61P35/00 , A61K39/395 , C07K16/30 , A61K39/00
-
公开(公告)号：EP3026064B1
公开(公告)日：2018-10-17
申请号：EP15201110.2
申请日：2012-04-20
申请人： Ganymed Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael , WEICHEL, Michael
IPC分类号： C07K16/30 , A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor- related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
-
公开(公告)号：EP2499161B8
公开(公告)日：2017-10-25
申请号：EP10778877.0
申请日：2010-11-11
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael
IPC分类号： C07K16/28 , C07K14/705 , A61P35/00 , A61K39/00 , C07K16/30
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
-
公开(公告)号：EP3421496A1
公开(公告)日：2019-01-02
申请号：EP18179328.2
申请日：2012-04-20
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael , WEICHEL, Michael
IPC分类号： C07K16/30 , A61K39/395 , C07K16/28 , A61K39/00
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor- related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
-
公开(公告)号：EP3283521A1
公开(公告)日：2018-02-21
申请号：EP16715583.7
申请日：2016-04-13
申请人： Ganymed Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , KREUZBERG, Maria , MITNACHT-KRAUS, Rita , LE GALL, Fabrice , JACOBS, Stefan
CPC分类号： A61K47/6859 , A61K31/40 , A61K47/6803 , A61K47/6849 , A61K47/6863 , A61K2039/505 , A61K2039/627 , A61P35/00 , A61P35/04 , C07K16/28 , C07K16/303 , C07K16/3046 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
-
公开(公告)号：EP3689911A1
公开(公告)日：2020-08-05
申请号：EP20151560.8
申请日：2010-11-11
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael
IPC分类号： C07K16/28 , C07K14/705 , A61P35/00 , A61K39/395 , C07K16/30 , A61K39/00 , A61P1/04 , A61P1/16 , A61P11/00 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P21/00 , A61P25/00 , A61P35/04 , A61P1/18
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
-
公开(公告)号：EP2499161B1
公开(公告)日：2017-09-06
申请号：EP10778877.0
申请日：2010-11-11
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael
IPC分类号： C07K16/28 , C07K14/705 , A61P35/00 , A61K39/00 , C07K16/30
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了用作治疗和/或预防与表达紧密连接蛋白-6（CLDN6）的细胞有关的疾病的抗体，所述疾病包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌 ，皮肤癌，恶性黑色素瘤，头颈部癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，宫颈癌，睾丸癌和子宫癌。
-
公开(公告)号：EP2707390B1
公开(公告)日：2015-12-30
申请号：EP12715856.6
申请日：2012-04-20
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael , WEICHEL, Michael
IPC分类号： A61P35/00 , C07K16/30 , A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
-
公开(公告)号：EP3738612A1
公开(公告)日：2020-11-18
申请号：EP20181374.8
申请日：2014-07-30
申请人： Biontech AG , Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , WAGNER, Meike , KREUZBERG, Maria , HÄCKER, Sabine , JACOBS, Stefan
IPC分类号： A61K39/395 , G01N33/50 , G01N33/569 , G01N33/574
摘要： The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.
-
公开(公告)号：EP3027208A1
公开(公告)日：2016-06-08
申请号：EP14750331.2
申请日：2014-07-30
申请人： Biontech AG , GANYMED Pharmaceuticals AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , WAGNER, Meike , KREUZBERG, Maria , HÄCKER, Sabine , JACOBS, Stefan
IPC分类号： A61K39/395 , A61K47/48 , G01N33/50 , G01N33/569 , G01N33/574
摘要： The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6, Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.024 秒)
