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公开(公告)号：EP3283521A1
公开(公告)日：2018-02-21
申请号：EP16715583.7
申请日：2016-04-13
申请人： Ganymed Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , KREUZBERG, Maria , MITNACHT-KRAUS, Rita , LE GALL, Fabrice , JACOBS, Stefan
CPC分类号： A61K47/6859 , A61K31/40 , A61K47/6803 , A61K47/6849 , A61K47/6863 , A61K2039/505 , A61K2039/627 , A61P35/00 , A61P35/04 , C07K16/28 , C07K16/303 , C07K16/3046 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP4364756A3
公开(公告)日：2024-07-31
申请号：EP24150410.9
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Denis Stefan , UTSCH, Magdalena Jadwiga , HEINZ, Cornelia Adriana Maria , STADLER, Christiane Regina
IPC分类号： A61K39/395 , C07K16/30 , A61K45/06 , A61P35/00
CPC分类号： A61K39/39558 , A61K45/06 , C07K16/30 , C07K16/3046 , A61K2039/50520130101 , A61P35/00 , C07K2317/73220130101 , C07K2317/7320130101 , C07K2317/73420130101
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP3725810A1
公开(公告)日：2020-10-21
申请号：EP20163993.7
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Stefan Denis , UTSCH, Magdalena Jadwiga , HEINZ, Cornelia Adriana Maria , STADLER, Christiane Regina
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K33/243 , A61K39/00 , A61P35/00 , C07K16/28
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP3254695B1
公开(公告)日：2020-09-09
申请号：EP17171169.0
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Stefan, Denis , UTSCH, Magdalena, Jadwiga , HEINZ, Cornelia, Adriana, Maria , STADLER, Christiane, Regina
IPC分类号： A61K39/395 , C07K16/30 , A61K45/06
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公开(公告)号：EP4119582A1
公开(公告)日：2023-01-18
申请号：EP22181929.5
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Stefan Denis , UTSCH, Magdalena Jadwiga , HEINZ, Cornelia Adriana Maria , STADLER, Christiane Regina
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K33/243 , A61K39/00 , A61P35/00 , C07K16/28
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP3679069A1
公开(公告)日：2020-07-15
申请号：EP18765858.8
申请日：2018-09-05
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
IPC分类号： C07K16/28
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公开(公告)号：EP2852409B1
公开(公告)日：2020-03-25
申请号：EP13729591.1
申请日：2013-05-21
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , JACOBS, Stefan Denis , UTSCH, Magdalena Jadwiga , HEINZ, Cornelia Adriana Maria , STADLER, Christiane Regina
IPC分类号： A61K39/395 , C07K16/30 , A61K45/06
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公开(公告)号：EP4331578A3
公开(公告)日：2024-06-05
申请号：EP23209136.3
申请日：2016-04-13
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , KREUZBERG, Maria , MITNACHT-KRAUS, Rita , LE GALL, Fabrice , JACOBS, Stefan
CPC分类号： C07K16/28 , C07K16/303 , C07K16/3046 , A61K2039/50520130101 , A61K2039/62720130101 , C07K2317/2420130101 , C07K2317/7720130101 , A61K47/6849 , A61K47/6863 , A61K47/6859 , A61P35/04 , A61P35/00 , A61K31/40 , A61K47/68031 , A61K47/68033
摘要： The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP4177273A1
公开(公告)日：2023-05-10
申请号：EP22201152.0
申请日：2014-02-18
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , WÖLL, Stefan , JACOBS, Stefan , HEINZ, Cornelia
IPC分类号： C07K16/30 , A61K39/00 , A61K39/395 , C07K16/28
摘要： The present invention provides a combination therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as pancreatic cancer and metastases thereof.
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公开(公告)号：EP2847225B1
公开(公告)日：2019-11-27
申请号：EP13721596.8
申请日：2013-05-06
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , MITNACHT-KRAUS, Rita , WÖLL, Stefan
IPC分类号： C07K16/30
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