公开(公告)号：EP3450428A1

公开(公告)日：2019-03-06

申请号：EP18197734.9

申请日：2014-11-26

申请人： GENENTECH, INC. ,  Xenon Pharmaceuticals Inc.

发明人： ANDREZ, Jean-Christophe ,  BICHLER, Paul Robert ,  CHEN, Chien-An ,  CHOWDHURY, Sultan ,  DECKER, Shannon Marie ,  DEHNHARDT, Christoph Martin ,  FOCKEN, Thilo ,  GRIMWOOD, Michael Edward ,  HEMEON, Ivan William ,  JIA, Qi ,  LI, Jun ,  LIU, Zhiguo ,  ORTWINE, Daniel F. ,  SAFINA, Brian ,  SUTHERLIN, Daniel ,  SHENG, Tao ,  SUN, Shaoyi ,  WHITE, Andrew D. ,  WILSON, Michael Scott ,  ZENOVA, Alla Yurevna ,  ZHU, Jiuxiang

IPC分类号： C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D451/02 ,  C07D451/06 ,  C07D205/12 ,  C07D295/155 ,  C07D211/96 ,  C07D295/26

摘要： The invention provides compounds having the general formula I:

and pharmaceutically acceptable salts thereof, wherein the variables R A , R AA , subscript n, ring A, X 2 , L, subscript m, X 1 , R 1 , R 2 , R 3 , R 4 , R 5 , and R N have the meaning as described herein; compositions containing such compounds; and such compounds and compositions for use in methods of treatment.

公开(公告)号：EP3297989A1

公开(公告)日：2018-03-28

申请号：EP16728782.0

申请日：2016-05-20

申请人： GENENTECH, INC. ,  Xenon Pharmaceuticals Inc.

发明人： CHOWDHURY, Sultan ,  DEHNHARDT, Christoph Martin ,  HASAN, Abid ,  HEMEON, Ivan William ,  JIA, Qi ,  LI, Jun ,  LIU, Zhiguo ,  ORTWINE, Daniel F. ,  SAFINA, Brian ,  SUTHERLIN, Daniel ,  SUN, Shaoyi ,  WHITE, Andrew D. ,  GONG, Wei ,  ZENOVA, Alla Yurevna ,  ZHU, Jiuxiang

IPC分类号： C07D211/22 ,  C07D211/38 ,  C07D211/48 ,  C07D211/62 ,  A61K31/445 ,  A61P25/00

CPC分类号： C07D211/22 ,  C07D211/34 ,  C07D211/38 ,  C07D211/42 ,  C07D211/48 ,  C07D211/62 ,  C07D221/20 ,  C07D401/04 ,  C07D401/08 ,  C07D401/12 ,  C07D405/08

摘要： The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：EP3074377B1

公开(公告)日：2018-10-17

申请号：EP14865855.2

申请日：2014-11-26

申请人： Genentech, Inc. ,  Xenon Pharmaceuticals Inc.

发明人： ANDREZ, Jean-Christophe ,  BICHLER, Paul Robert ,  CHEN, Chien-An ,  CHOWDHURY, Sultan ,  DECKER, Shannon Marie ,  DEHNHARDT, Christoph Martin ,  FOCKEN, Thilo ,  GRIMWOOD, Michael Edward ,  HEMEON, Ivan William ,  JIA, Qi ,  LI, Jun ,  LIU, Zhiguo ,  ORTWINE, Daniel F. ,  SAFINA, Brian ,  SUTHERLIN, Daniel ,  SHENG, Tao ,  SUN, Shaoyi ,  WHITE, Andrew D. ,  WILSON, Michael Scott ,  ZENOVA, Alla Yurevna ,  ZHU, Jiuxiang

IPC分类号： C07D211/42 ,  C07D211/22

CPC分类号： A61K31/445 ,  A61K31/337 ,  A61K31/397 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4412 ,  A61K31/4523 ,  A61K31/4545 ,  A61K31/495 ,  C07D205/04 ,  C07D205/12 ,  C07D207/12 ,  C07D211/22 ,  C07D211/32 ,  C07D211/42 ,  C07D211/54 ,  C07D211/60 ,  C07D211/96 ,  C07D233/68 ,  C07D237/08 ,  C07D241/04 ,  C07D265/30 ,  C07D295/155 ,  C07D295/26 ,  C07D305/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D451/02 ,  C07D451/06 ,  C07D453/02 ,  C07D487/08 ,  C07F7/0812

摘要： The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compactions.

公开(公告)号：EP3074377A1

公开(公告)日：2016-10-05

申请号：EP14865855.2

申请日：2014-11-26

申请人： Genentech, Inc. ,  Xenon Pharmaceuticals Inc.

发明人： ANDREZ, Jean-Christophe ,  BICHLER, Paul Robert ,  CHEN, Chien-An ,  CHOWDHURY, Sultan ,  DECKER, Shannon Marie ,  DEHNHARDT, Christoph Martin ,  FOCKEN, Thilo ,  GRIMWOOD, Michael Edward ,  HEMEON, Ivan William ,  JIA, Qi ,  LI, Jun ,  LIU, Zhiguo ,  ORTWINE, Daniel F. ,  SAFINA, Brian ,  SUTHERLIN, Daniel ,  SHENG, Tao ,  SUN, Shaoyi ,  WHITE, Andrew D. ,  WILSON, Michael Scott ,  ZENOVA, Alla Yurevna ,  ZHU, Jiuxiang

IPC分类号： C07D205/04 ,  C07D207/12 ,  C07D211/42 ,  C07D233/68 ,  C07D237/08 ,  C07D241/04 ,  C07D305/08 ,  A61K31/337 ,  A61K31/397 ,  A61K31/415 ,  A61K31/4412 ,  A61K31/495 ,  A61K31/4015 ,  A61P25/04

CPC分类号： A61K31/445 ,  A61K31/337 ,  A61K31/397 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4412 ,  A61K31/4523 ,  A61K31/4545 ,  A61K31/495 ,  C07D205/04 ,  C07D207/12 ,  C07D211/22 ,  C07D211/32 ,  C07D211/42 ,  C07D211/54 ,  C07D211/60 ,  C07D233/68 ,  C07D237/08 ,  C07D241/04 ,  C07D265/30 ,  C07D305/08 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D453/02 ,  C07D487/08 ,  C07F7/0812

摘要： The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RA, RAA, subscript n, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, and RN have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compactions.

摘要翻译： 其中变量RA，RAA，亚基n，环A，X2，L，下标m，X1，R1，R2，R3，R4，R5和RN具有本文所述的含义， 化合物和使用这些化合物和组合物的方法。