-
公开(公告)号：EP1351744B1
公开(公告)日：2007-10-03
申请号：EP01966399.6
申请日：2001-08-29
申请人： GENENTECH, INC.
CPC分类号： C07K14/82 , A61K38/00 , C07K14/4756 , C07K16/32 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30 , G01N33/5061
摘要： The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.
-
2.发明公开SECRETED AMD TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开分泌的AMD跨膜多肽和编码相同的核酸
公开(公告)号：EP1135495A2
公开(公告)日：2001-09-26
申请号：EP99968054.9
申请日：1999-12-01
申请人： Genentech, Inc.
发明人： BAKER, Kevin, P. , BOTSTEIN, David , EATON, Dan, L. , FERRARA, Napoleone , FILVAROFF, Ellen , GERRITSEN, Mary, E. , GODDARD, Audrey , GODOWSKI, Paul, J. , GRIMALDI, Christopher, J. , GURNEY, Austin, L. , HILLAN, Kenneth, J. , KLJAVIN, Ivar, J. , NAPIER, Mary, a. , ROY, Margaret, Ann , TUMAS, Daniel , WOOD, William, I.
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及分泌和跨膜多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法 发明。
-
公开(公告)号：EP1595145A2
公开(公告)日：2005-11-16
申请号：EP04713365.7
申请日：2004-02-20
申请人： Genentech Inc.
IPC分类号： G01N33/574 , C07K16/28 , A61K39/395 , A61K48/00 , C12Q1/68
CPC分类号： G01N33/57438 , A61K48/00 , A61K2039/505 , C07K14/82 , C07K16/30 , C07K16/3076 , G01N33/57484 , G01N2333/726 , G01N2500/00
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma or Wilms tumor.
-
4.发明公开COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF DISORDERS INVOLVING ANGIOGENESIS 审中-公开组合物和方法血管生成相关的疾病的诊断和治疗
公开(公告)号：EP1309685A2
公开(公告)日：2003-05-14
申请号：EP01951036.1
申请日：2001-07-09
申请人： Genentech, Inc. , Baker, Kevin P. , Ferrara, Napoleone , Gerber, Hanspeter , Gerritsen, Mary E. , Goddard, Audrey , Godowski, Paul J. , Gurney, Austin L. , Hillan, Kenneth J. , Marsters, Scot A. , Pan, James , Paoni, Nicholas F. , Stephan, Jean-Philippe F. , Watanabe, Colin K. , Williams, P. Mickey , Wood, William I.
发明人： BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , GERRITSEN, Mary, E. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , HILLAN, Kenneth, J. , MARSTERS, Scot, A. , PAN, James , PAONI, Nicholas, F. , STEPHAN, Jean-Philippe, F. , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I. , YE, Weilan
IPC分类号： C12N15/12 , C07K14/475 , C07K16/22 , A61K38/00
CPC分类号： C07K14/515
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
-
5.发明公开NOVEL POLYPEPTIDES, THEIR NUCLEIC ACIDS, AND METHODS FOR THEIR USE IN ANGIOGENESIS AND VASCULARIZATION 审中-公开聚氨酯在多伦多维多利亚州的NUKLEINSÄUREN，DEREN VERWENDUNGEN在DER ANGIOGENESE UND VASKULARISATION
公开(公告)号：EP1224282A2
公开(公告)日：2002-07-24
申请号：EP00970592.2
申请日：2000-10-05
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00 , C12N2799/027
摘要： The present invention is directed to novel polypeptides critical for angiogenesis and vascularization, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or neo- or cardio-vascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis.
摘要翻译： 本发明涉及对血管生成和血管形成至关重要的新型多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 公开了用于刺激或抑制包括人在内的哺乳动物的血管发生和/或新生血管形成或心脏血管形成的组合物和方法。 药物组合物基于已被鉴定用于这些用途中的一种或多种的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如伤口; 各种癌症和血管障碍，包括动脉粥样硬化。
-
6.发明授权PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION BY TUMOR NECROSIS FACTOR LIGAND/RECEPTOR HOMOLOGS 有权刺激或肿瘤坏死因子配体/受体同源抑制血管生成和HERZVASKULARISIERUNG
公开(公告)号：EP1196186B1
公开(公告)日：2007-10-31
申请号：EP00947204.4
申请日：2000-07-11
申请人： GENENTECH, INC.
IPC分类号： A61K38/17
CPC分类号： G01N33/566 , A61K38/177 , C07K14/47 , C07K2319/30 , C12N2799/026 , G01N2333/525 , G01N2333/70575 , G01N2333/70578
-
7.发明公开PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION BY TUMOR NECROSIS FACTOR LIGAND/RECEPTOR HOMOLOGS 有权刺激或肿瘤坏死因子配体/受体同源抑制血管生成和HERZVASKULARISIERUNG
公开(公告)号：EP1196186A2
公开(公告)日：2002-04-17
申请号：EP00947204.4
申请日：2000-07-11
申请人： Genentech, Inc.
IPC分类号： A61K38/17 , C12Q1/68 , G01N33/50 , G01N33/68 , G01N33/574 , C07G17/00 , A61K39/395 , A61P9/00 , A61P35/00 , A61P27/02
CPC分类号： G01N33/566 , A61K38/177 , C07K14/47 , C07K2319/30 , C12N2799/026 , G01N2333/525 , G01N2333/70575 , G01N2333/70578
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.
-
公开(公告)号：EP1112361A2
公开(公告)日：2001-07-04
申请号：EP99946891.1
申请日：1999-09-13
申请人： Genentech, Inc.
发明人： FONG, Sherman , GERRITSEN, Mary, E. , GODDARD, Audrey , GURNEY, Austin, L. , HILLAN, Kenneth, J. , WILLIAMS, P., Mickey , WOOD, William, I.
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein included trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.
摘要翻译： 公开了用于刺激或抑制包括人在内的哺乳动物的血管生成和/或心血管形成的组合物和方法。 药物组合物基于已鉴定用于一种或多种这些用途的多肽或拮抗剂。 可由本文组合物诊断，预防或治疗的疾病包括创伤如创伤，各种癌症和血管病症，包括动脉粥样硬化和心脏肥大。
-
公开(公告)号：EP1351744A2
公开(公告)日：2003-10-15
申请号：EP01966399.6
申请日：2001-08-29
申请人： Genentech, Inc.
CPC分类号： C07K14/82 , A61K38/00 , C07K14/4756 , C07K16/32 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30 , G01N33/5061
摘要： The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.
-
10.发明公开COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF DISORDERS INVOLVING ANGIOGENESIS 审中-公开组合物和诊断方法和治疗疾病的为其血管生成的作用
公开(公告)号：EP1309620A2
公开(公告)日：2003-05-14
申请号：EP01957073.8
申请日：2001-06-20
申请人： Genentech, Inc.
发明人： BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , GERRITSEN, Mary, E. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , HILLAN, Kenneth, J. , MARSTERS, Scot, A. , PAN, James , PAONI, Nicholas, F. , STEPHAN, Jean-Philippe, F. , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I. , YE, Weilan
CPC分类号： C07K14/47
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
-
-
-
-
-
-
-
-
-
搜索结果
19 条记录 (耗时 0.025 秒)
