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公开(公告)号：EP1210418A1
公开(公告)日：2002-06-05
申请号：EP00916675.2
申请日：2000-03-30
申请人： Genentech Inc.
发明人： ASHKENAZI, Avi, J , BAKER, Kevin P. , BOTSTEIN, David , DESNOYERS, Luc , EATON, Dan,L. , FERRARA, Napoleone , GERBER, Hanspeter , GERRITSEN, Mary,E , GODDARD, Audrey , GODOWSKI, PaulJ. , GRIMALDI, Christipher, J , GURNEY, Austin, L. , KLJAVIN, Ivar,J. , NAPIER,Mary, A , PAN, James , PAONI, Nicholas F. , ROY, Margaret,Ann , STEWART, Timothy, A , TUMAS, Daniel , WATANABE, Colin, K , WILLIAMS, P.,Mickey , WOOD, William, I , ZHANG, Zemin
CPC分类号： A61K38/17 , C07K14/005 , C07K14/47 , C07K14/705 , C07K16/18 , C12N2710/16222
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1210418B1
公开(公告)日：2010-08-18
申请号：EP00916675.2
申请日：2000-03-30
申请人： Genentech, Inc.
发明人： ASHKENAZI, Avi, J , BAKER, Kevin P. , BOTSTEIN, David , DESNOYERS, Luc , EATON, Dan,L. , FERRARA, Napoleone , GERBER, Hanspeter , GERRITSEN, Mary,E , GODDARD, Audrey , GODOWSKI, PaulJ. , GRIMALDI, Christipher, J , GURNEY, Austin, L. , KLJAVIN, Ivar,J. , NAPIER,Mary, A , PAN, James , PAONI, Nicholas F. , ROY, Margaret,Ann , STEWART, Timothy, A , TUMAS, Daniel , WATANABE, Colin, K , WILLIAMS, P.,Mickey , WOOD, William, I , ZHANG, Zemin , FONG, Sherman
IPC分类号： C12N15/12 , C07K14/47 , C07K14/705 , C12N15/62 , C07K16/18 , G01N33/53 , A61K38/17 , A61K31/7088
CPC分类号： A61K38/17 , C07K14/005 , C07K14/47 , C07K14/705 , C07K16/18 , C12N2710/16222
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3.发明授权
公开(公告)号：EP1212417B1
公开(公告)日：2008-04-30
申请号：EP00939307.5
申请日：2000-05-17
申请人： Genentech Inc.
发明人： ASKENAZI, Avi J. , BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , GERRITSEN, Mary, E. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , KUO, Sophia, S. , MARK, Malanie, R. , MARSTERS, Scot, A. , PAONI, Nicholas, F. , PITTI, Robert, M. , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I.
IPC分类号： C12N15/12 , C07K14/47 , C07K14/52 , A61K38/17 , C07K16/18 , G01N33/53 , C12Q1/68 , C12N15/11 , C12N15/86
CPC分类号： G01N33/5011 , A61K38/00 , C07K14/475 , C07K14/52 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , G01N2800/32
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：EP1648939A2
公开(公告)日：2006-04-26
申请号：EP04779660.2
申请日：2004-07-30
申请人： GENENTECH, INC.
发明人： FUH, Germaine , GERBER, Hanspeter , LIANG, Wei-Ching , FELLOUSE, Frederic, A. , SIDHU, Sachdev, S. , WIESMANN, Christian
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
摘要： Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the synthetic antibodies in research, diagnostic and therapeutic applications.
摘要翻译： 公开了抗VEGF抗体及其变体，包括对VEGF结合具有高亲和力的抗体。 还提供了使用噬菌体展示技术与初始文库产生和选择具有期望的结合和其他生物活性的抗VEGF抗体的方法。 进一步考虑的是合成抗体在研究，诊断和治疗应用中的用途。
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5.发明公开PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION 审中-公开刺激或抑制血管生成和HERZVASKULARISIERUNG
公开(公告)号：EP1159419A1
公开(公告)日：2001-12-05
申请号：EP00912015.5
申请日：2000-02-24
申请人： Genentech, Inc.
发明人： ASHKENAZI, Avi, J. , BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , GERRITSEN, Mary, E. , GODDARD, Audrey , GURNEY, Austin, L. , HILLAN, Kenneth, J. , MARSTERS, Scot, A. , PAONI, Nicholas, F. , PITTI, Robert, M. , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I.
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4703 , C07K14/70578 , C07K16/18 , C07K2317/24 , C07K2319/00 , C12N2799/026 , C12N2799/027 , G01N2800/32
摘要： Compositions and methods are disclosed for stimulting or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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6.发明授权PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION 有权促销或血管生成与KARDIOVASKULARISATION的抑制作用
公开(公告)号：EP1135485B1
公开(公告)日：2010-02-17
申请号：EP99960624.7
申请日：1999-11-30
申请人： Genentech, Inc.
发明人： ASHKENAZI, Avi, J. , BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , HILLAN, Kenneth, J. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , KLEIN, Robert, D. , KUO, Sophia, S. , PAONI, Nicholas, F. , SMITH, Victoria , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I.
IPC分类号： C12N15/12 , C07K14/47 , A61K38/17 , C07K16/18 , G01N33/53 , C12Q1/68 , C12N15/62 , C12N15/11
CPC分类号： C12N9/6408 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C12N2799/026 , C12Y304/21034 , G01N2800/32
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7.发明公开COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF DISORDERS INVOLVING ANGIOGENESIS 审中-公开组合物和方法血管生成相关的疾病的诊断和治疗
公开(公告)号：EP1309685A2
公开(公告)日：2003-05-14
申请号：EP01951036.1
申请日：2001-07-09
申请人： Genentech, Inc. , Baker, Kevin P. , Ferrara, Napoleone , Gerber, Hanspeter , Gerritsen, Mary E. , Goddard, Audrey , Godowski, Paul J. , Gurney, Austin L. , Hillan, Kenneth J. , Marsters, Scot A. , Pan, James , Paoni, Nicholas F. , Stephan, Jean-Philippe F. , Watanabe, Colin K. , Williams, P. Mickey , Wood, William I.
发明人： BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , GERRITSEN, Mary, E. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , HILLAN, Kenneth, J. , MARSTERS, Scot, A. , PAN, James , PAONI, Nicholas, F. , STEPHAN, Jean-Philippe, F. , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I. , YE, Weilan
IPC分类号： C12N15/12 , C07K14/475 , C07K16/22 , A61K38/00
CPC分类号： C07K14/515
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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8.发明公开
公开(公告)号：EP1263948A2
公开(公告)日：2002-12-11
申请号：EP00907314.9
申请日：2000-02-18
申请人： Genentech, Inc.
发明人： ASZKENAZI, Avi J. , BAKER, Kevin P. , BOTSTEIN, David , DESNOYERS, Luc , EATON, Dan L. , FERRARA, Napoleone , FILVAROFF, Ellen , FONG, Sherman , GAO, Wei-Qiang , GERBER, Hanspeter , GERRITSEN, Mary E. , GODDARD, Audrey , GODOWSKI, Paul J. , GRIMALDI, Christopher G. , GURNEY, Austin L. , HILLAN, Kenneth J. , KLJAVIN, Ivar J. , KUO, Sophia S. , NAPIER, Mary A. , PAN, James , PAONI, Nicholas F. , ROY, Margaret Ann , SHELTON, David L. , STEWART, Timothy A. , TUMAS, Daniel , WILLIAMS, P. Mickey , WOOD, William I.
IPC分类号： C12N15/12 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C07K14/47 , C07K14/705 , C07K19/00 , C07K16/18 , C07K16/28 , G01N33/68 , G01N33/543 , A61K47/48 , A61K51/08 , A61K38/17
CPC分类号： C07K16/18 , A61K38/00 , A61K47/64 , C07K14/47 , C07K14/4703 , C07K14/705 , C07K14/70578 , C07K16/28 , C07K2317/24 , C07K2319/00 , C12N2799/026 , C12N2799/027
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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9.发明公开PROMOTION OR INHIBITION OF ANGIOGENESIS AND CARDIOVASCULARIZATION 有权促销或血管生成与KARDIOVASKULARISATION的抑制作用
公开(公告)号：EP1135485A2
公开(公告)日：2001-09-26
申请号：EP99960624.7
申请日：1999-11-30
申请人： Genentech, Inc.
发明人： ASHKENAZI, Avi, J. , BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , HILLAN, Kenneth, J. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , KLEIN, Robert, D. , KUO, Sophia, S. , PAONI, Nicholas, F. , SMITH, Victoria , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I.
IPC分类号： C12N15/12 , C07K14/47 , A61K38/17 , C07K16/18 , G01N33/53 , C12Q1/68 , C12N15/62 , C12N15/11
CPC分类号： C12N9/6408 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K16/18 , C12N2799/026 , C12Y304/21034 , G01N2800/32
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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10.发明公开COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF DISORDERS INVOLVING ANGIOGENESIS 审中-公开组合物和诊断方法和治疗疾病的为其血管生成的作用
公开(公告)号：EP1309620A2
公开(公告)日：2003-05-14
申请号：EP01957073.8
申请日：2001-06-20
申请人： Genentech, Inc.
发明人： BAKER, Kevin, P. , FERRARA, Napoleone , GERBER, Hanspeter , GERRITSEN, Mary, E. , GODDARD, Audrey , GODOWSKI, Paul, J. , GURNEY, Austin, L. , HILLAN, Kenneth, J. , MARSTERS, Scot, A. , PAN, James , PAONI, Nicholas, F. , STEPHAN, Jean-Philippe, F. , WATANABE, Colin, K. , WILLIAMS, P., Mickey , WOOD, William, I. , YE, Weilan
CPC分类号： C07K14/47
摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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