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1.发明授权TESTS TO PREDICT RESPONSIVENESS OF CANCER PATIENTS TO CHEMOTHERAPY TREATMENT OPTIONS 有权测试为癌症患者的治疗方案化疗的预测应答率
公开(公告)号：EP2294215B1
公开(公告)日：2013-01-16
申请号：EP09747388.8
申请日：2009-05-12
申请人： Genomic Health, Inc. , Aventis Inc.
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/57415 , G01N2333/705 , G01N2333/72 , G01N2800/52 , G01N2800/60
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2.发明公开TESTS TO PREDICT RESPONSIVENESS OF CANCER PATIENTS TO CHEMOTHERAPY TREATMENT OPTIONS 有权测试为癌症患者的治疗方案化疗的预测应答率
公开(公告)号：EP2294215A1
公开(公告)日：2011-03-16
申请号：EP09747388.8
申请日：2009-05-12
申请人： Genomic Health, Inc. , Aventis Inc.
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/57415 , G01N2333/705 , G01N2333/72 , G01N2800/52 , G01N2800/60
摘要： The present disclosure provides methods and compositions to facilitate prediction of the likelihood of responsiveness of cancer patients to treatment including a taxane and/or a cyclophosphamide.
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公开(公告)号：EP1678327A2
公开(公告)日：2006-07-12
申请号：EP04794735.3
申请日：2004-10-11
申请人： Genomic Health, Inc.
CPC分类号： C12Q1/6806 , C12Q2561/101 , C12Q2537/143
摘要： The invention concerns an integrated, qRT-PCR-based system for analyzing and reporting RNA expression profiles of biological samples. In particular, the invention concerns a fully optimized and integrated multiplex, multi-analyte method for expression profiling of RNA in biological samples, including fixed, paraffin-embedded tissue samples. The gene expression profiles obtained can be used for the clinical diagnosis, classification and prognosis of various pathological conditions, including cancer.
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公开(公告)号：EP1488007A1
公开(公告)日：2004-12-22
申请号：EP03744665.5
申请日：2003-03-12
申请人： Genomic Health, Inc.
发明人： BAKER, Joffre, B. , CRONIN, Maureen, T. , KIEFER, Michael, C. , SHAK, Steve , WALKER, Michael, G.
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
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5.发明授权
公开(公告)号：EP2598659B1
公开(公告)日：2015-03-11
申请号：EP11813024.4
申请日：2011-07-25
申请人： Genomic Health, Inc.
发明人： SHAK, Steven , BAEHNER, Frederick, L. , MADDALA, Tara , LEE, Mark , PELHAM, Robert, J. , COWENS, Wayne , CHERBAVAZ, Diana , KIEFER, Michael, C. , CRAGER, Michael , GODDARD, Audrey , BAKER, Joffre, B.
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , G06F19/00
摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.
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6.发明公开
公开(公告)号：EP1974058A2
公开(公告)日：2008-10-01
申请号：EP07717900.0
申请日：2007-01-11
发明人： COWENS, Wayne , BAKER, Joffre, B. , CLARK, Kim , HACKETT, James , WATSON, Drew , PAIK, Soonmyung
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： A method of predicting clinical outcome for a human subject diagnosed with colorectal cancer following surgical resection of said cancer is disclosed. A normalized expression level is determined of an RNA transcript of MYBL2, or an expression product thereof, in a biological sample comprising cancer cells obtained from said human subject. The likelihood of a positive clinical outcome for said human subject is then predicted based on said normalized expression level, wherein normalized expression of an RNA transcript of MYBL2, or an expression product thereof, is positively correlated with an increased likelihood of a positive clinical outcome.
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7.发明公开
公开(公告)号：EP2598659A2
公开(公告)日：2013-06-05
申请号：EP11813024.4
申请日：2011-07-25
申请人： Genomic Health, Inc.
发明人： SHAK, Steven , BAEHNER, Frederick, L. , MADDALA, Tara , LEE, Mark , PELHAM, Robert, J. , COWENS, Wayne , CHERBAVAZ, Diana , KIEFER, Michael, C. , CRAGER, Michael , GODDARD, Audrey , BAKER, Joffre, B.
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , G06F19/00
摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.
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公开(公告)号：EP1631689A2
公开(公告)日：2006-03-08
申请号：EP04776118.4
申请日：2004-05-24
申请人： Genomic Health, Inc.
发明人： BAKER, Joffre, B. , MILLER, Kathy, D. , SHAK, Steven , SLEDGE, George, W. , SOULE, Sharon, E. Indiana Univ. School of Medicine
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/106 , C12Q2600/158
摘要： The invention provides sets of genes the expression of which predicts whether cancer patients are likely to have a beneficial treatment response to chemotherapy.
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公开(公告)号：EP1570080A1
公开(公告)日：2005-09-07
申请号：EP03786796.7
申请日：2003-11-14
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16
摘要： The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFRexpressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
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10.发明授权
公开(公告)号：EP1974058B1
公开(公告)日：2014-06-11
申请号：EP07717900.0
申请日：2007-01-11
发明人： COWENS, Wayne , BAKER, Joffre, B. , CLARK, Kim , HACKETT, James , WATSON, Drew , PAIK, Soonmyung
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
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