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1.发明授权
公开(公告)号：EP2615183B1
公开(公告)日：2014-10-08
申请号：EP13163561.7
申请日：2009-05-13
发明人： Baker, Joffre , Watson, Drew , Maddala, Tara , Shak, Steven , Mauro, David, J. , Ford, Shirin, K.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
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2.发明公开
公开(公告)号：EP2615183A1
公开(公告)日：2013-07-17
申请号：EP13163561.7
申请日：2009-05-13
发明人： Baker, Joffre , Watson, Drew , Maddala, Tara , Shak, Steven , Mauro, David, J. , Ford, Shirin, K.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The present invention provides methods and compositions to facilitate determining whether an EGFR-expressing cancer in an individual is an EGFR inhibitor-responsive cancer, as well as methods for determining the likelihood that a patient having an EGFR-expressing cancer will exhibit a beneficial response to an EGFR inhibitor therapy. The methods generally involve determining a normalized expression level of a gene product that correlates with EGFR inhibitor responsiveness.
摘要翻译： 本发明提供了有助于确定个体中EGFR表达的EGFR是否是EGFR抑制剂反应性癌症的方法和组合物，以及用于确定具有EGFR表达癌症的患者的可能性将表现出对 EGFR抑制剂治疗。 所述方法通常涉及确定与EGFR抑制剂反应性相关的基因产物的归一化表达水平。
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3.发明授权Tests to predict responsiveness of cancer patients to chemotherapy treatment options 有权预测癌症患者对化疗治疗选择的反应性的测试
公开(公告)号：EP2607497B1
公开(公告)日：2014-10-01
申请号：EP13159677.7
申请日：2009-05-12
发明人： Shak, Steve , Baker, Joffre , Yoshizawa, Carl , Gray, Robert , Sparano, Joseph
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/57415 , G01N2333/705 , G01N2333/72 , G01N2800/52 , G01N2800/60
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4.发明公开Prediction of likelihood of cancer recurrence 有权Vorhersage der Wahrscheinlichkeit eines Wiederauftretens von Krebs
公开(公告)号：EP2775000A1
公开(公告)日：2014-09-10
申请号：EP14163233.1
申请日：2004-06-17
发明人： Baker, Joffre , Bryant, John L. , Paik, Soonmyung , Shak, Steve
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.
摘要翻译： 本发明提供了基因组，其表达在癌症，特别是乳腺癌的诊断和/或预后中是重要的。
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公开(公告)号：EP2412820A1
公开(公告)日：2012-02-01
申请号：EP10194713.3
申请日：2007-01-11
发明人： Cowens, Wayne , Hackett, James , Watson, Drew , Paik, Soonmyung , Clark, Kim , Baker, Joffre
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of an RNA transcript of FAP or an expression product thereof in a biological sample of cancer cells obtained from the subject.
摘要翻译： 预测诊断患有结肠直肠癌的受试者的临床结果的方法，包括确定从受试者获得的癌细胞的生物样品中FAP的RNA转录物或其表达产物的表达的证据。
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6.发明授权
公开(公告)号：EP2913405B1
公开(公告)日：2016-11-09
申请号：EP15152517.7
申请日：2011-07-25
申请人： Genomic Health, Inc.
发明人： Shak, Steve , Baehner, Frederick L. , Maddala, Tara , Lee, Mark , Pelham, Robert J. , Cowens, Wayne , Cherbavaz, Diana , Kiefer, Michael C. , Crager, Michael , Goddard, Audrey , Baker, Joffre
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , G06F19/00
摘要： Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.
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7.发明授权Tests to predict responsiveness of cancer patients to chemotherapy treatment options 有权测试预测癌症患者的化疗治疗方案的响应
公开(公告)号：EP2568053B1
公开(公告)日：2014-04-16
申请号：EP12195318.6
申请日：2009-05-12
申请人： Genomic Health, Inc. , Aventis Inc.
发明人： Shak, Steve , Baker, Joffre , Yoshizawa, Carl , Sparano, Joseph , Gray, Robert
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/574 , G01N33/57415 , G01N2333/705 , G01N2333/72 , G01N2800/52 , G01N2800/60
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公开(公告)号：EP2412823A1
公开(公告)日：2012-02-01
申请号：EP10194719.0
申请日：2007-01-11
发明人： Cowens, Wayne , Baker, Joffre , Hackett, James , Watson, Drew , Paik, Soonmyung , Clark, Kim
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of an RNA transcript of EFNB2 or an expression product thereof in a biological sample of cancer cells obtained from the subject.
摘要翻译： 预测诊断为结肠直肠癌的受试者的临床结果的方法，包括确定从受试者获得的癌细胞的生物样品中EFNB2的RNA转录物或其表达产物的表达的证据。
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9.发明公开Gene expression markers for colorectal cancer prognosis 有权AREG als Genexpressionsmarker zur Kolorektalkrebsprognose
公开(公告)号：EP2412821A1
公开(公告)日：2012-02-01
申请号：EP10194714.1
申请日：2007-01-11
发明人： Cowens, Wayne , Baker, Joffre , Hackett, James , Watson, Drew , Paik, Soonmyung , Clark, Kim
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57419 , G01N33/57446
摘要： A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of an RNA transcript of AREG or its expression product in a biological sample of cancer cells obtained from the subject.
摘要翻译： 一种预测诊断为结肠直肠癌的受试者的临床结果的方法，包括确定从受试者获得的癌细胞的生物样品中AREG或其表达产物的RNA转录物的表达的证据。
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公开(公告)号：EP3170906B1
公开(公告)日：2018-08-22
申请号：EP16196459.8
申请日：2004-06-17
发明人： Baker, Joffre , Shak, Steve , Bryant, John , Paik, Soonmyung
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.
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