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公开(公告)号：EP3154960A1
公开(公告)日：2017-04-19
申请号：EP15739038.6
申请日：2015-06-10
发明人： CAI, Shaopei , DU, Zhimin , KIM, Musong , LOYER-DREW, Jennifer, A. , NADUTHAMBI, Devan , PATEL, Leena , PHILLIPS, Barton, W. , PHILLIPS, Gary , STEVENS, Kirk, L. , TREIBERG, Jennifer, Anne , VAN VELDHUIZEN, Joshua , WATKINS, William, J. , YEUNG, Suet, Chung
IPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , C07D473/34 , C07D487/04 , C07D513/04 , A61K31/517 , A61P35/00 , A61P37/00 , A61P25/28 , A61P3/08 , A61P9/10
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/04 , C07D473/34 , C07D487/04 , C07D513/04
摘要： The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein n, W, A′, B′, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.
摘要翻译： 本申请提供式（J）化合物或其药学上可接受的盐，异构体，互变异构体或其混合物，其中本文描述了n，W，A'，B'，R 1，R 2和R 3。 这些化合物是磷脂酰肌醇3-激酶（PI3K）活性的抑制剂，可用于治疗由一种或多种PI3K同种型介导的病症。 本申请还提供包含式（I）化合物或其药学上可接受的盐，异构体，互变异构体或其混合物的药物组合物，以及使用这些化合物和组合物治疗由一种或多种PI3K同种型介导的病症的方法。
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公开(公告)号：EP3154969B1
公开(公告)日：2019-10-09
申请号：EP15734488.8
申请日：2015-06-10
发明人： DU, Zhimin , EVARTS, Jerry , KAPLAN, Joshua , KIM, Musong , NADUTHAMBI, Devan , PATEL, Leena , PERREAULT, Stephane , PHILLIPS, Barton, W. , PHILLIPS, Gary , STEVENS, Kirk, L. , TREIBERG, Jennifer , VAN VELDHUIZEN, Joshua , WATKINS, William, J. , YEUNG, Suet, Chung
IPC分类号： C07D471/04 , C07D403/12 , C07D413/14 , C07D403/14 , C07D239/91 , C07D487/04 , C07D513/04 , A61P35/00 , A61P25/00 , A61K31/517
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公开(公告)号：EP3160960A1
公开(公告)日：2017-05-03
申请号：EP15739079.0
申请日：2015-06-23
发明人： EVARTS, Jerry , KAPLAN, Joshua , KIM, Musong , NADUTHAMBI, Devan , PATEL, Leena , PERRAULT, Stephane , PHILLIPS, Gary , PURVIS, Lafe, J., II , STEVENS, Kirk, L. , TREIBERG, Jennifer, A.
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D403/14 , C07D409/14 , C07D491/107 , A61K31/517 , A61P35/00 , A61P37/00 , A61P29/00
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D491/107
摘要： The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (J), or pharmaceutically acceptable salts thereof, in which A, n, m, R
1 , R
2 , R
3 R
4 , R
5 , R
6 and R
7 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more ΡI3Κ isoforms. The present disclosure further provides pharmaceutical compositions that include a compound of formula (J), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms.摘要翻译： 本公开提供了式（J）的磷脂酰肌醇3-激酶（PBK）抑制剂或其药学上可接受的盐，其中A，n，m，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。 这些化合物可用于治疗由一种或多种PI3K同种型介导的病症。 本公开进一步提供了包含式（J）化合物或其药学上可接受的盐的药物组合物，以及使用这些化合物和组合物治疗由一种或多种PI3K同种型介导的病症的方法。
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公开(公告)号：EP3154969A1
公开(公告)日：2017-04-19
申请号：EP15734488.8
申请日：2015-06-10
发明人： DU, Zhimin , EVARTS, Jerry , KAPLAN, Joshua , KIM, Musong , NADUTHAMBI, Devan , PATEL, Leena , PERREAULT, Stephane , PHILLIPS, Barton, W. , PHILLIPS, Gary , STEVENS, Kirk, L. , TREIBERG, Jennifer , VAN VELDHUIZEN, Joshua , WATKINS, William, J. , YEUNG, Suet, Chung
IPC分类号： C07D471/04 , C07D403/12 , C07D413/14 , C07D403/14 , C07D239/91 , C07D487/04 , C07D513/04 , A61P35/00 , A61P25/00 , A61K31/517
CPC分类号： C07D513/04 , C07D239/91 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D473/34 , C07D487/04
摘要： The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, or a mixture thereof, wherein n, m, q, A′, W1, W2, W3, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.
摘要翻译： 本申请提供式（J）化合物或其药学上可接受的盐，异构体或其混合物，其中本文描述了n，m，q，A'，W1，W2，W3，R 1，R 2和R 3。 这些化合物是磷脂酰肌醇3-激酶（PI3K）活性的抑制剂，可用于治疗由一种或多种PI3K同种型介导的病症。 本申请还提供包含式（J）化合物或其药学上可接受的盐，异构体，互变异构体或其混合物的药物组合物，以及使用这些化合物和组合物治疗由一种或多种PI3K同种型介导的病症的方法。
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公开(公告)号：EP3896064A1
公开(公告)日：2021-10-20
申请号：EP21162393.9
申请日：2016-06-30
发明人： BACON, Elizabeth, M. , BALAN, Gayatri , CHOU, Chien-Hung , CLARK, Christopher, T. , COTTELL, Jeromy, J. , KIM, Musong , KIRSCHBERG, Thorsten, A. , LINK, John, O. , PHILLIPS, Gary , SCHROEDER, Scott, D. , SQUIRES, Neil, H. , STEVENS, Kirk, L. , TAYLOR, James, G. , WATKINS, William, J. , WRIGHT, Nathan, E. , ZIPFEL, Sheila, M.
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04 , C07D495/04 , A61K31/4709 , A61P29/00 , A61P35/00
摘要： The present disclosure relates to 4,6-diamino-quinoline-3-carbonitrile derivatives for use as modulators of COT (Cancer Osaka Thyroid) in methods of treating Crohn's disease and ulcerative colitis.
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6.发明公开6-AMINO-QUINOLINE-3-CARBONITRILS AS COT MODULATORS 审中-公开6-AMINO-QUINOLINE-3-CARBONITRILS COT MODULATORS
公开(公告)号：EP3319955A1
公开(公告)日：2018-05-16
申请号：EP16741446.5
申请日：2016-06-30
发明人： BACON, Elizabeth, M. , BALAN, Gayatri , CHOU, Chien-hung , CLARK, Christopher, T. , COTTELL, Jeromy, J. , KIM, Musong , KIRSCHBERG, Thorsten, A. , LINK, John, O. , PHILLIPS, Gary , SCHROEDER, Scott, D. , SQUIRES, Neil, H. , STEVENS, Kirk, L. , TAYLOR, James, G. , WATKINS, William, J. , WRIGHT, Nathan, E. , ZIPFEL, Sheila, M.
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , A61K31/4709 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D453/02 , C07F7/0814
摘要： The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
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公开(公告)号：EP3319955B1
公开(公告)日：2020-11-25
申请号：EP16741446.5
申请日：2016-06-30
发明人： BACON, Elizabeth, M. , BALAN, Gayatri , CHOU, Chien-hung , CLARK, Christopher, T. , COTTELL, Jeromy, J. , KIM, Musong , KIRSCHBERG, Thorsten, A. , LINK, John, O. , PHILLIPS, Gary , SCHROEDER, Scott, D. , SQUIRES, Neil, H. , STEVENS, Kirk, L. , TAYLOR, James, G. , WATKINS, William, J. , WRIGHT, Nathan, E. , ZIPFEL, Sheila, M.
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , A61K31/4709 , A61P29/00 , A61P35/00 , A61P37/00
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公开(公告)号：EP3456717A1
公开(公告)日：2019-03-20
申请号：EP18186568.4
申请日：2016-06-30
发明人： BACON, Elizabeth, M. , BALAN, Gayatri , CHOU, Chien-Hung , CLARK, Christopher, T. , COTTELL, Jeromy, J. , KIM, Musong , KIRSCHBERG, Thorsten, A. , LINK, John, O. , PHILLIPS, Gary , SCHROEDER, Scott, D. , SQUIRES, Neil, H. , STEVENS, Kirk, L. , TAYLOR, James, G. , WATKINS, William, J. , WRIGHT, Nathan, E. , ZIPFEL, Sheila, M.
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04 , C07D495/04 , A61K31/4709 , A61P29/00 , A61P35/00
摘要： Tablets containing 4,6-diamino-quinoline-3-carbonitrile derivatives as cancer Osaka thyroid (COT) modulators for treating cancer.
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公开(公告)号：EP2569285A1
公开(公告)日：2013-03-20
申请号：EP11719748.3
申请日：2011-05-09
发明人： BAKER, William, R. , CAI, Shaopei , KAPLAN, Joshua, Aaron , KIM, Musong , LOYER-DREW, Jennifer, Alissa , PERREAULT, Stephane , PHILLIPS, Gary , PURVIS, Lafe, J., II , STASIAK, Marcin , STEVENS, Kirk, L. , VAN VELDHUIZEN, Josh
IPC分类号： C07D215/54 , C07D401/12 , C07D409/14 , C07D413/12 , A61K31/4706 , A61K31/4709 , A61P11/00
CPC分类号： C07D215/54 , C07D401/12 , C07D409/14 , C07D413/12
摘要： Provided are compounds of Formula (I): Wherein X is:(Formula (II)) or (Formula (III)) R
1 and R
2 together with the phenyl to which they are bound may form a bicyclic, fused heterocyclic ring, and all other variables are as defined herein, as well as their use in treating pulmonary inflammation or bronchoconstriction and compositions comprising and processes for preparing the same.-
公开(公告)号：EP3191470B1
公开(公告)日：2019-02-27
申请号：EP16738976.6
申请日：2016-06-30
发明人： BACON, Elizabeth, M. , BALAN, Gayatri , CHOU, Chien-Hung , CLARK, Christopher, T. , COTTELL, Jeromy, J. , KIM, Musong , KIRSCHBERG, Thorsten, A. , LINK, John, O. , PHILLIPS, Gary , SCHROEDER, Scott, D. , SQUIRES, Neil, H. , STEVENS, Kirk, L. , TAYLOR, James, G. , WATKINS, William, J. , WRIGHT, Nathan, E. , ZIPFEL, Sheila, M.
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D409/14 , C07D417/14 , C07D471/04 , C07D495/04 , A61K31/4709 , A61P29/00 , A61P35/00
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