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1.发明公开
公开(公告)号：EP2220077A1
公开(公告)日：2010-08-25
申请号：EP08863729.3
申请日：2008-12-19
申请人： Glaxo Group Limited
发明人： HEER, Jag, Paul , HEIGHTMAN, Thomas, Daniel , HURST, David, Nigel , JOHNSON, Christopher, Norbert , SKIDMORE, John , WALL, Ian, David
IPC分类号： C07D413/04 , C07D413/14 , A61K31/553 , A61P37/00
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives of formula (I) or a pharmaceutically acceptable salt thereof thereof. Compounds of formula (I) and their pharmaceutically acceptable salts are of use in the treatment of conditions or disorders which are mediated via the S1 P1 receptor. In particular the compounds of formula (I) and their pharmaceutically acceptable salts are of use in the treatment of multiple sclerosis, autoimmune diseases, chronic inflammatory disorders, asthma, inflammatory neuropathies, arthritis, transplantation, Crohn's disease, ulcerative colitis, lupus erythematosis, psoriasis, ischemia-reperfusion injury, solid tumours, and tumour metastasis, diseases associated with angiogenesis, vascular diseases, pain conditions, acute viral diseases, inflammatory bowel conditions, insulin and non-insulin dependant diabetes.
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公开(公告)号：EP2271643A1
公开(公告)日：2011-01-12
申请号：EP09738180.0
申请日：2009-04-29
申请人： Glaxo Group Limited
发明人： ELDRED, Colin, David , HEER, Jag, Paul , HEIGHTMAN, Thomas, Daniel , SKIDMORE, John , WANG, Hailong
IPC分类号： C07D413/04 , C07D413/14 , A61K31/4725 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P3/10 , A61P19/02 , A61P29/00 , A61P9/10 , A61P11/06 , A61P17/06
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
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公开(公告)号：EP2271643B1
公开(公告)日：2012-08-15
申请号：EP09738180.0
申请日：2009-04-29
申请人： Glaxo Group Limited
发明人： ELDRED, Colin, David , HEER, Jag, Paul , HEIGHTMAN, Thomas, Daniel , SKIDMORE, John , WANG, Hailong
IPC分类号： C07D413/04 , C07D413/14 , A61K31/4725 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P3/10 , A61P19/02 , A61P29/00 , A61P9/10 , A61P11/06 , A61P17/06
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
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4.发明公开OXADIAZOLE DERIVATIVES FOR USE AS S1P1 AGONISTS IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS 审中-公开恶二唑AS S1P1激动剂自身免疫和炎性疾病的治疗
公开(公告)号：EP2222670A1
公开(公告)日：2010-09-01
申请号：EP08864758.1
申请日：2008-12-19
申请人： Glaxo Group Limited
IPC分类号： C07D413/04 , A61K31/4245 , A61P37/00
CPC分类号： C07D413/04
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
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公开(公告)号：EP2222669A1
公开(公告)日：2010-09-01
申请号：EP08864021.4
申请日：2008-12-19
申请人： Glaxo Group Limited
发明人： DEMONT, Emmanuel, Hubert , HEER, Jag, Paul , HEIGHTMAN, Thomas, Daniel , HURST, David, Nigel , JOHNSON, Christopher, Norbert , SKIDMORE, John , WALL, Ian, David , WITHERINGTON, Jason
IPC分类号： C07D413/04 , C07D413/14 , C07D223/16 , C07D267/14 , C07D271/06 , A61P37/00 , A61P17/00 , A61K31/55
CPC分类号： C07D223/16 , C07D267/14 , C07D271/06 , C07D413/04 , C07D413/14
摘要： The present application discloses oxadiazole based compounds of Formula (I) active on sphingosine-1-phosphate (S1P) in particular useful to treat lupus erythematosus. A is phenyl or a 5 or 6-membered heteroaryl ring; R1 is up to two substituents independently selected from halogen, C(1-3)aIkoxy, C(1-3)flyoroalkyl, cyano, optionally substituted phenyl. C(1-3)fluoroalkoxy. C(1-6)alkyl and C(3-6)Cyctoalkyl; R2 is hydrogen, halogen or C(1-4)alkyl; B is a 7 membered saturated ring selected from the following: Formulae (a) (b) (c) R3 is hydrogen or (CH2)1-4MCO2H; R4 is hydrogen or C(1-3)alkyl optionally interrupted by oxygen;
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公开(公告)号：EP2222669B1
公开(公告)日：2013-08-21
申请号：EP08864021.4
申请日：2008-12-19
申请人： Glaxo Group Limited
发明人： DEMONT, Emmanuel, Hubert , HEER, Jag, Paul , HEIGHTMAN, Thomas, Daniel , HURST, David, Nigel , JOHNSON, Christopher, Norbert , SKIDMORE, John , WALL, Ian, David , WITHERINGTON, Jason
IPC分类号： C07D413/04 , C07D413/14 , C07D223/16 , C07D267/14 , C07D271/06 , A61P37/00 , A61P17/00 , A61K31/55
CPC分类号： C07D223/16 , C07D267/14 , C07D271/06 , C07D413/04 , C07D413/14
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公开(公告)号：EP1546107B1
公开(公告)日：2010-03-31
申请号：EP03795019.3
申请日：2003-09-12
申请人： GLAXO GROUP LIMITED , Beswick, Paul , Modi, Sandeep , Pegg, Neil , Skidmore, John , Swarbrick, Martin
发明人： BESWICK, Paul , MODI, Sandeep , PEGG, Neil , SKIDMORE, John , SWARBRICK, Martin
IPC分类号： C07D213/64 , A61K31/4418 , A61P29/00 , C07D213/74 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D409/12
CPC分类号： C07D213/74 , C07D213/64 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a variety of conditions and diseases.
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公开(公告)号：EP1546107A1
公开(公告)日：2005-06-29
申请号：EP03795019.3
申请日：2003-09-12
申请人： GLAXO GROUP LIMITED , Beswick, Paul , Modi, Sandeep , Pegg, Neil , Skidmore, John , Swarbrick, Martin
发明人： BESWICK, Paul , MODI, Sandeep , PEGG, Neil , SKIDMORE, John , SWARBRICK, Martin
IPC分类号： C07D213/64 , A61K31/4418 , A61P29/00 , C07D213/74 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D409/12
CPC分类号： C07D213/74 , C07D213/64 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/12
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a variety of conditions and diseases.
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