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    PAPER-BASED SYNTHETIC GENE NETWORKS
    1.
    发明公开
    PAPER-BASED SYNTHETIC GENE NETWORKS 审中-公开
    PAPIERBASIERTE SYNTHETISCHE GENNETZWERKE

    公开(公告)号：EP3077551A4

    公开(公告)日：2017-05-31

    申请号：EP14868654

    申请日：2014-12-05

    申请人： HARVARD COLLEGE ,  UNIV BOSTON

    发明人： PARDEE KEITH ,  COLLINS JAMES J

    IPC分类号： C12Q1/68 ,  A61K9/14

    CPC分类号： C12Q1/6897 ,  C12Q1/6806 ,  C12Q2521/119 ,  C12Q2527/125

    摘要： Disclosed herein are shelf-stable compositions based on synthetic gene networks and/or cell-free systems that are lyophilized on a solid support. The compositions can be easily transported and stored for a period of time, and activation can be done by simply adding water. Methods of use are also disclosed herein, including, but are not limited to, sensing and a variety of logic functions. The invention permits straightforward, sterile and abiotic distribution of synthetic biology-based technology to clinical settings, food processing and industry, the military and consumer products.

    摘要翻译： 本文公开了基于冻干在固体支持物上的合成基因网络和/或无细胞系统的货架稳定的组合物。 该组合物可以容易地运输和储存一段时间，并且可以通过简单地添加水来进行活化。 本文还公开了使用方法，包括但不限于感测和各种逻辑功能。 本发明允许基于合成生物学的技术直接，无菌和非生物分布到临床环境，食品加工和工业，军事和消费品。

    METHOD AND APPARATUS FOR IMPROVING HUMAN BALANCE AND GAIT AND PREVENTING FOOT INJURY
    3.
    发明公开
    METHOD AND APPARATUS FOR IMPROVING HUMAN BALANCE AND GAIT AND PREVENTING FOOT INJURY 有权
    方法和设备改善人体平衡和团伙和脚伤的预防

    公开(公告)号：EP1608303A4

    公开(公告)日：2014-03-05

    申请号：EP04718493

    申请日：2004-03-08

    申请人： UNIV BOSTON

    发明人： HARRY JASON D ,  COLLINS JAMES J ,  NIEMI JAMES B ,  PRIPLATA ATTILA A ,  KLESHINSKI STEPHEN J

    IPC分类号： A61H23/02 ,  A43B3/00 ,  A43B7/00 ,  A43B7/14 ,  A43B13/00 ,  A43B17/00 ,  A43B19/00 ,  A61F5/01 ,  A61F5/14 ,  A61H1/00 ,  A61H39/00 ,  A61N1/04 ,  A61N1/20 ,  A61N1/32 ,  A61N2/06

    CPC分类号： A61H1/00 ,  A43B3/0005 ,  A43B7/00 ,  A43B7/1465 ,  A43B13/00 ,  A43B17/00 ,  A43B19/00 ,  A61F5/0111 ,  A61F5/14 ,  A61H39/002 ,  A61H2205/125 ,  A61N1/0456 ,  A61N1/0468 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/20 ,  A61N1/32 ,  A61N2/06

    摘要： A method and wearable system and for enhancing human balance and gait and preventing foot injury through neurological stimulation of the foot and the ankle. Subthreshold stimulation for neurosensory enhancement is provided via electrodes or vibrational actuators, or combination thereof, disposed in or on a wearable a platform, such as an insole, sock shoe, removable shoe insert, or applied without the support of a platform, to the skin surface of an individual. Suprathreshold stimulation for therapeutic purposes, such as improving blood flow, is also provided by the vibrational actuators. The actuators and electrodes are driven by bias signals generated by a bias signal generator that is coupled to a controller. The signal generator under the control of the controller is adapted to generate a non-deterministic random signal, a repetitive pattern or series of patterns. The controller optionally includes a communication port for interfacing with an external computer for purposes of optimizing and programming the controller. The wearable system is powered by a power source.

    摘要翻译： 一种方法和可穿戴式系统，并提高人体平衡和步态，并通过足部和踝关节的神经刺激防止脚受伤。 为感觉神经增强亚阈值刺激经由电极或振动致动器，或组合来提供它们，设置在或可佩戴的平台，检查作为鞋垫，袜子鞋，可移动鞋垫，或应用不支持的平台的，给皮肤 的个体的表面上。 超阈值刺激用于治疗目的，颜色：例如提高血流量，因此由振动致动器提供。 致动器和电极通过由偏置信号发生器产生并耦合到控制器偏置信号驱动。 所述控制器的控制下，信号发生器被angepasst以产生非确定性随机信号，重复图案或一系列图案。 控制器可选地包括用于与用于优化和对控制器编程的目的外部计算机的接口的通信端口。 的可穿戴系统由电源供电。

    SYSTEMS AND METHODS FOR REVERSE ENGINEERING MODELS OF BIOLOGICAL NETWORKS
    5.
    发明公开
    SYSTEMS AND METHODS FOR REVERSE ENGINEERING MODELS OF BIOLOGICAL NETWORKS 审中-公开
    系统和方法生物网络模型的逆向工程。

    公开(公告)号：EP1488235A4

    公开(公告)日：2006-09-20

    申请号：EP03716281

    申请日：2003-03-05

    申请人： UNIV BOSTON

    发明人： GARDNER TIMOTHY S ,  COLLINS JAMES J ,  DI BERNARDO DIEGO ,  TEGNER JESPER ,  YEUNG MAN KIT STEPHEN

    IPC分类号： G01N33/53 ,  G06F19/12

    CPC分类号： G06F19/12 ,  G06F19/18 ,  G06F19/24

    摘要： The present invention provides methods and accompanying computer-based systems and computer-executable code stored on a computer-readable medium for constructing a model of a biological network. The invention further provides methods for performing sensitivity analysis on a biological network and for identifying major regulators of species in the network and of the network as a whole. In addition, the invention provides methods for identifying targets of a perturbation such as that resulting from exposure to a compound or an environmental change. The invention further provides methods for identifying phenotypic mediators that contribute to differences in phenotypes of biological systems.