公开(公告)号：EP0805701A1

公开(公告)日：1997-11-12

申请号：EP95943417.0

申请日：1995-12-08

Applicant: HEARTPORT, INC.

Inventor： BOYD, Stephen, W. ,  STEVENS, John, H. ,  EVARD, Philip, C. ,  ADAMS, Craig, L.

IPC: A61B17 ,  A61F2 ,  A61M1 ,  A61M25 ,  A61M29

CPC classification number: A61B17/29 ,  A61B17/320016 ,  A61B2017/00243 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/2433 ,  A61F2/2436 ,  A61M1/3653 ,  A61M1/3659 ,  A61M25/0032 ,  A61M25/0041 ,  A61M25/0125 ,  A61M25/0147 ,  A61M25/0152 ,  A61M25/0662 ,  A61M25/10 ,  A61M25/1002 ,  A61M2025/0031 ,  A61M2025/004 ,  A61M2025/0078 ,  A61M2025/0161 ,  A61M2025/028 ,  A61M2025/1047 ,  A61M2025/1052 ,  A61M2025/1077 ,  A61M2025/1095 ,  A61M2205/11 ,  A61M2205/366 ,  A61M2210/125 ,  A61M2210/127

Abstract: A retrograde delivery catheter (10) includes at its distal end a balloon (11) configured to occlude the coronary sinus (21) of a patient's heart, and has a length and flexibility which allow the distal end to be positioned in the coronary sinus (21) with the proximal end extending trans-luminal to a peripheral vein such as an internal jugular vein (44) and out of the body through a puncture (24) therein. The delivery catheter (20) has a delivey lumen (128) extending between its proximal and distal ends which is configured to allow a cardioplegia fluid to be delivered at a flow rate of at least 200 ml/min with a pump pressure less than 300 mm Hg, thereby allowing cardioplegia arrest to be maintained using a blood cardioplegia fluid without causing excessive hemolysis. In a method of inducing cardioplegia arrest according to the invention, the patient is placed on cardiopulmonary bypass (18), the coronary arteries (50, 51) are isolated from remainder of the arterial system, and the delivery catheter (10) is positioned trans-luminal in the coronary sinus (21) from a peripheral vein.

公开(公告)号：EP0819014B1

公开(公告)日：2003-02-05

申请号：EP96908755.0

申请日：1996-03-12

Applicant: HEARTPORT, INC.

Inventor： STEVENS, John, H. ,  KRIER, Jeffrey, W. ,  VALLEY, Kirsten, L. ,  EVARD, Philip, C.

IPC: A61M29/00 ,  A61M29/02

CPC classification number: A61M25/0041 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61F2/2433 ,  A61F2/2436 ,  A61M1/3653 ,  A61M1/3659 ,  A61M25/007 ,  A61M25/0125 ,  A61M25/0662 ,  A61M25/10 ,  A61M29/02 ,  A61M2025/0004 ,  A61M2025/0078 ,  A61M2025/028 ,  A61M2025/1047 ,  A61M2025/1052 ,  A61M2025/1077 ,  A61M2210/125 ,  A61M2210/127

Abstract: A venting catheter, system and method, are provided for withdrawing blood and other fluids from a patient's heart to facilitate decompressing the heart during cardioplegia arrest and cardiopulmonary bypass, without the need for a thoracotomy and without puncturing the aorta, pulmonary artery, or heart itself. The venting catheter (602) is configured to be introduced into a peripheral vein and intra-luminal advanced through the right side of the heart and into the pulmonary artery. The venting catheter includes a lumen (610) configured to withdraw blood at a rate of at least about 50 ml/min at a pressure of no less than about -350 mmHg. A flow directing means (615) is provided to facilitate guiding the catheter into the pulmonary artery by being carried by blood flow through the heart. The cardiac venting system may include, in addition to the cardiac venting catheter, a cardiopulmonary bypass system to maintain circulation of oxygenated blood, and means for arresting the patient's heart.

公开(公告)号：EP0737083A1

公开(公告)日：1996-10-16

申请号：EP95905887.0

申请日：1994-12-08

Applicant: HEARTPORT, INC.

Inventor： EVARD, Philip, C. ,  MACHOLD, Timothy, R. ,  GIFFORD, Hanson, S., III ,  ROTH, Alex, T. ,  STERMAN, Wesley, D. ,  SIEGEL, Lawrence, C.

IPC: A61B1 ,  A61B17 ,  A61B18 ,  A61B19 ,  A61F2 ,  A61M1 ,  A61M25

CPC classification number: A61B17/0218 ,  A61B17/00234 ,  A61B17/0057 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/06061 ,  A61B17/064 ,  A61B17/068 ,  A61B17/12013 ,  A61B17/122 ,  A61B17/1227 ,  A61B17/1285 ,  A61B17/29 ,  A61B17/2909 ,  A61B17/295 ,  A61B17/30 ,  A61B17/34 ,  A61B17/3403 ,  A61B18/1442 ,  A61B18/1492 ,  A61B90/50 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00353 ,  A61B2017/00544 ,  A61B2017/00637 ,  A61B2017/00663 ,  A61B2017/0243 ,  A61B2017/047 ,  A61B2017/0472 ,  A61B2017/0474 ,  A61B2017/0475 ,  A61B2017/2905 ,  A61B2017/2933 ,  A61B2017/2943 ,  A61B2017/2945 ,  A61B2017/2946 ,  A61B2017/306 ,  A61B2017/3405 ,  A61B2017/3427 ,  A61B2017/3445 ,  A61B2017/3492 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61B2018/00291 ,  A61B2018/00363 ,  A61B2018/00392 ,  A61B2018/00577 ,  A61B2018/1432 ,  A61B2090/064 ,  A61F2/2427 ,  A61M25/01 ,  A61M25/1011 ,  A61M39/0247 ,  A61M2025/0003 ,  A61M2025/0089 ,  A61M2025/028 ,  A61M2039/0279 ,  A61M2202/047 ,  A61M2205/3344 ,  A61M2205/3355 ,  A61M2205/366 ,  A61M2210/127 ,  Y10S128/26 ,  A61M2230/005

Abstract: The invention provides devices and methods for thoracoscopically arresting the heart and establishing cardiopulmonary bypass, thus facilitating a variety of less invasive surgical procedures on and within the heart and great vessels of the thorax. In one embodiment, the invention provides a thoracoscopic system for arresting a patient's heart including a clamp (32) configured for introduction into the patient's thoracic cavity through a percutaneous intercostal penetration in the patient's chest. The clamp is positionable about the patient's ascending aorta between the coronary arteries and the brachio-cephalic artery. The clamp (32) is coupled to the distal end of an elongated handle means (36) for manipulating the clamp (32) from a location outside of the patient's thoracic cavity. A means for actuating the clamp (36) is coupled to the proximal end (23) of the handle means (36). When actuated, the clamp (32) blocks blood flow through the ascending aorta. A delivery cannula (44) may be used to deliver cardio-plegic fluid into the ascending aorta upstream from the clamp (32) to arrest cardiac function.

公开(公告)号：EP0841963B1

公开(公告)日：2004-03-10

申请号：EP95941419.4

申请日：1995-11-21

Applicant: HEARTPORT, INC.

Inventor： ST. GOAR, Frederick, G. ,  PETERS, William, S. ,  EVARD, Philip, C. ,  BOYD, Stephen, W. ,  ADAMS, Craig, L. ,  MUELLER, Richard, L., Jr. ,  STEVENS, John, H.

IPC: A61M29/00 ,  A61M25/00 ,  A61M25/10

CPC classification number: A61M25/0068 ,  A61B2017/00243 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61F2/2427 ,  A61M1/3653 ,  A61M1/3659 ,  A61M25/0041 ,  A61M25/005 ,  A61M25/008 ,  A61M25/01 ,  A61M25/0125 ,  A61M25/0662 ,  A61M25/10 ,  A61M25/1002 ,  A61M2025/0031 ,  A61M2025/0034 ,  A61M2025/0036 ,  A61M2025/004 ,  A61M2025/0057 ,  A61M2025/0078 ,  A61M2025/0087 ,  A61M2025/028 ,  A61M2025/1047 ,  A61M2025/1077 ,  A61M2205/11 ,  A61M2205/366 ,  A61M2210/125

Abstract: A catheter system is provided for accessing the coronary ostia (176, 180) transluminal from a peripheral arterial access site, such as the femoral artery, and for inducing cardioplegia arrest by direct infusion of cardioplegia solution into the coronary arteries. In a first embodiment, the catheter system is in the form of a single perfusion catheter (20) with multiple distal branches (24, 26, 28) for engaging the coronary ostia (176, 180). In a second embodiment, multiple perfusion catheters (82, 84) are delivered to the coronary ostia (176, 180) through a single arterial cannula (104). In a third embodiment, multiple perfusion catheters (112, 114, 116) are delivered to the coronary ostia (176, 180) through a single guiding catheter (126). In a fourth embodiment, multiple catheters (140, 142, 144) are delivered to the coronary ostia (176, 180) through a single guiding catheter (130) which has distal exit ports (134, 136, 138) that are arranged to direct the perfusion catheters into the coronary ostia (176, 180). In each embodiment, the catheters (20) are equipped with an occlusion means (30, 50) at the distal end of the catheter (20) for closing the coronary ostia (176, 180), and isolating the coronary arteries from the systemic blood flow.

公开(公告)号：EP0841963A1

公开(公告)日：1998-05-20

申请号：EP95941419.0

申请日：1995-11-21

Applicant: HEARTPORT, INC.

Inventor： ST. GOAR, Frederick, G. ,  PETERS, William, S. ,  EVARD, Philip, C. ,  BOYD, Stephen, W. ,  ADAMS, Craig, L. ,  MUELLER, Richard, L., Jr. ,  STEVENS, John, H.

IPC: A61F2 ,  A61M1 ,  A61M25 ,  A61B17 ,  A61M29

CPC classification number: A61M25/0068 ,  A61B2017/00243 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61F2/2427 ,  A61M1/3653 ,  A61M1/3659 ,  A61M25/0041 ,  A61M25/005 ,  A61M25/008 ,  A61M25/01 ,  A61M25/0125 ,  A61M25/0662 ,  A61M25/10 ,  A61M25/1002 ,  A61M2025/0031 ,  A61M2025/0034 ,  A61M2025/0036 ,  A61M2025/004 ,  A61M2025/0057 ,  A61M2025/0078 ,  A61M2025/0087 ,  A61M2025/028 ,  A61M2025/1047 ,  A61M2025/1077 ,  A61M2205/11 ,  A61M2205/366 ,  A61M2210/125

Abstract: A catheter system is provided for accessing the coronary ostia (176, 180) transluminal from a peripheral arterial access site, such as the femoral artery, and for inducing cardioplegia arrest by direct infusion of cardioplegia solution into the coronary arteries. In a first embodiment, the catheter system is in the form of a single perfusion catheter (20) with multiple distal branches (24, 26, 28) for engaging the coronary ostia (176, 180). In a second embodiment, multiple perfusion catheters (82, 84) are delivered to the coronary ostia (176, 180) through a single arterial cannula (104). In a third embodiment, multiple perfusion catheters (112, 114, 116) are delivered to the coronary ostia (176, 180) through a single guiding catheter (126). In a fourth embodiment, multiple catheters (140, 142, 144) are delivered to the coronary ostia (176, 180) through a single guiding catheter (130) which has distal exit ports (134, 136, 138) that are arranged to direct the perfusion catheters into the coronary ostia (176, 180). In each embodiment, the catheters (20) are equipped with an occlusion means (30, 50) at the distal end of the catheter (20) for closing the coronary ostia (176, 180), and isolating the coronary arteries from the systemic blood flow.

公开(公告)号：EP0819014A1

公开(公告)日：1998-01-21

申请号：EP96908755.0

申请日：1996-03-12

Applicant: HEARTPORT, INC.

Inventor： STEVENS, John, H. ,  KRIER, Jeffrey, W. ,  VALLEY, Kirsten, L. ,  EVARD, Philip, C.

IPC: A61F2 ,  A61M1 ,  A61M25 ,  A61M29

CPC classification number: A61M25/0041 ,  A61B2018/00232 ,  A61B2018/00261 ,  A61F2/2433 ,  A61F2/2436 ,  A61M1/3653 ,  A61M1/3659 ,  A61M25/007 ,  A61M25/0125 ,  A61M25/0662 ,  A61M25/10 ,  A61M29/02 ,  A61M2025/0004 ,  A61M2025/0078 ,  A61M2025/028 ,  A61M2025/1047 ,  A61M2025/1052 ,  A61M2025/1077 ,  A61M2210/125 ,  A61M2210/127

Abstract: A venting catheter, system and method, are provided for withdrawing blood and other fluids from a patient's heart to facilitate decompressing the heart during cardioplegia arrest and cardiopulmonary bypass, without the need for a thoracotomy and without puncturing the aorta, pulmonary artery, or heart itself. The venting catheter (602) is configured to be introduced into a peripheral vein and intra-luminal advanced through the right side of the heart and into the pulmonary artery. The venting catheter includes a lumen (610) configured to withdraw blood at a rate of at least about 50 ml/min at a pressure of no less than about -350 mmHg. A flow directing means (615) is provided to facilitate guiding the catheter into the pulmonary artery by being carried by blood flow through the heart. The cardiac venting system may include, in addition to the cardiac venting catheter, a cardiopulmonary bypass system to maintain circulation of oxygenated blood, and means for arresting the patient's heart.