Abstract:
Methods and devices for selectively removing an agent from a physiological efferent fluid collection site are provided. A feature of the invention is that a non-occlusive aspiration device is employed to selectively remove the target agent from the site only when the target agent is present in the site. Also provided are systems and kits for performing the subject methods. The subject invention finds use in a variety of different applications, including the selective removal of both therapeutic and diagnostic agents from a variety of different physiological sites.
Abstract:
Devices and methods are provided for temporarily inducing cardio-plegia arrest in the heart of a patient, and for establishing cardiopulmonary bypass in order to facilitate surgical procedures onthe heart and its related blood vessels. Specifically, a catheterbased system is provided for isolating the heart and coronary blood vessels of a patient from the remainder of the arterial system(850), and for infusing a cardio-plegia agent into the patient's coronary arteries to induce cardio-plegia arrest in the heart. The system includes an endo-aortic partitioning catheter (10) having an expandable balloon (11, 161) at its distal end, which is expanded within the ascending aorta (12, 157) to occlude the aortic lumen between the coronary ostia and the brachio-cephalic artery. Means for centering the catheter tip (330) within the ascending aorta include specially curved shaft configurations (1600), eccentric (710) or shaped (792) occlusion balloons (161, 350), and a steerable catheter tip (145) which may be used separately or in combination. The shaft of the catheter may have a coaxial (106) or multilumen (602) construction.
Abstract:
The subject invention relates to a valve replacement system together with methods of preparation and use, are provided for endovascular replacement of a heart valve in a host. The valve replacement system includes up to five components: (1) a prosthetic valve device, (2) a valve introducer device, (3) an intraluminal procedure device, (4) a procedure device capsule, and (5) a tissue cutter. The system provides for endovascular removal of a malfunctioning valve and subsequent replacement with a permanent prosthetic heart valve.
Abstract:
A venting catheter, system and method, are provided for withdrawing blood and other fluids from a patient's heart to facilitate decompressing the heart during cardioplegia arrest and cardiopulmonary bypass, without the need for a thoracotomy and without puncturing the aorta, pulmonary artery, or heart itself. The venting catheter (602) is configured to be introduced into a peripheral vein and intra-luminal advanced through the right side of the heart and into the pulmonary artery. The venting catheter includes a lumen (610) configured to withdraw blood at a rate of at least about 50 ml/min at a pressure of no less than about -350 mmHg. A flow directing means (615) is provided to facilitate guiding the catheter into the pulmonary artery by being carried by blood flow through the heart. The cardiac venting system may include, in addition to the cardiac venting catheter, a cardiopulmonary bypass system to maintain circulation of oxygenated blood, and means for arresting the patient's heart.
Abstract:
This invention is a device for crossing a stenotic intravascular lesion for occluding blood flow downstream from the intravascular lesion, and for use as an exchange guide wire, and a method of using the device; the device comprising a balloon catheter (10) having a catheter body with an inflation conduit, an inflation balloon (20), an adapter (18) for inflating the inflation balloon, and an extension member (22). The device is configured such that the inflation balloon is maintained in an inflated state by connecting the extension member (22) to the proximal end of the inflation conduit when the adapter is removed.
Abstract:
The subject invention relates to a valve replacement system together with methods of preparation and use, are provided for endovascular replacement of a heart valve in a host. The valve replacement system includes up to five components: (1) a prosthetic valve device, (2) a valve introducer device, (3) an intraluminal procedure device, (4) a procedure device capsule, and (5) a tissue cutter. The system provides for endovascular removal of a malfunctioning valve and subsequent replacement with a permanent prosthetic heart valve.