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公开(公告)号：EP2711713A4
公开(公告)日：2015-04-22
申请号：EP12785094
申请日：2012-04-17
IPC分类号： G01N35/00
CPC分类号： G01N35/00584 , G01N35/00693 , G01N2035/00673 , G01N2035/00702 , G01N2035/0453
摘要： Accuracy control of an automatic analysis device that mixes a sample and a reagent to measure temporal change of a mixed solution is realized. A plurality of measurement point data is acquired from a reaction process of the sample and the reagent. Parameters and test values of approximate equations for approximating the plurality of measurement point data are accumulated in a storage unit. A distribution map of reference data corresponding to the parameters or the test values is created based on predetermined numbers of the parameters or the test values accumulated in the storage unit. Next, a plurality of screens for individually superimposing, on the distribution map, curved lines corresponding to a plurality of regression function candidates obtained by applying a plurality of regression functions are arranged and presented on a display screen, so as to approximate the data to the distribution map of the reference data.
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公开(公告)号：EP2453224A4
公开(公告)日：2015-05-27
申请号：EP10797092
申请日：2010-07-05
CPC分类号： G01N21/51 , G01N15/0205 , G01N21/253 , G01N2015/0065 , G01N2035/00396 , G01N2035/0453
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公开(公告)号：EP2708873A4
公开(公告)日：2014-10-08
申请号：EP12784970
申请日：2012-05-09
CPC分类号： G01N35/025 , G01N21/51 , G01N21/82 , G01N2021/4711 , G01N2035/0453
摘要： An object of the present invention is to obtain desired quantitative determination results for measurements having a broad dynamic range and for measurements with high sensitivity without altering a device configuration or a reagent. In view of this, the present invention provides an automatic analysis device which measures time sequential data on a scattered light amount as reaction process data, and quantitatively determines the concentration of an analyte from a change in light amount. The automatic analysis device has a function of selecting reaction process data to be used for quantitative determination from the reaction process data obtained by measurement using a plurality of light receivers at different angles. As a result of using this function, data is selected from the reaction process data obtained by measurement using the plurality of light receivers at different angles in accordance with the concentration of the analyte and whether the priority is given to high sensitivity in the case where sensitivity is prioritized or a dynamic range, and the result of the quantitative determination is displayed.
摘要翻译： 本发明的目的是为了获得具有宽动态范围的测量和用于高灵敏度的测量而不改变器件配置或试剂的所需的定量测定结果。 鉴于此，本发明提供了一种自动分析装置，其测量作为反应过程数据的散射光量的时间顺序数据，并且从光量的变化定量地确定分析物的浓度。 自动分析装置具有从通过使用多个不同角度的光接收器的测量获得的反应过程数据中选择要用于定量确定的反应过程数据的功能。 作为使用该功能的结果，从根据分析物的浓度以不同角度通过使用多个光接收器的测量获得的反应过程数据中选择数据，以及在灵敏度的情况下是否给予高灵敏度的优先级 优先或动态范围，并显示定量确定的结果。
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公开(公告)号：EP2876429A4
公开(公告)日：2016-03-30
申请号：EP13820255
申请日：2013-06-13
IPC分类号： G01N21/13 , G01N21/27 , G01N21/49 , G01N21/51 , G01N21/53 , G01N21/59 , G01N35/00 , G01N35/02
CPC分类号： G01N35/025 , G01N21/13 , G01N21/272 , G01N21/31 , G01N21/49 , G01N21/51 , G01N21/532 , G01N21/59 , G01N35/00613 , G01N2035/0453 , G01N2201/02 , G01N2201/062
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5.发明公开AUTOMATIC ANALYSIS DEVICE AND METHOD FOR DETERMINING MALFUNCTION THEREOF 审中-公开VERFAHREN ZUR BESTIMMUNG EINER FEHLFUNKTION DAVON汽车修理
公开(公告)号：EP2759835A4
公开(公告)日：2015-04-22
申请号：EP12833461
申请日：2012-05-17
CPC分类号： G01F23/00 , G01F23/263 , G01L7/00 , G01N35/1011 , G01N2035/009 , G01N2035/1018 , G01N2035/1025
摘要： An automatic analyzer which performs a suction operation a plurality of times on a same sample has a sample dispensing unit 9, a liquid level sensor which detects the liquid level of the sample in a sample vessel 8, an arithmetic unit 5 which computes a liquid level height h1 at the end of a first suction operation of the two consecutive suction operations from a liquid level height h0 and a sample suction volume V1 detected at the start of the first suction operation, a storage unit 7 which stores the liquid level height h1 computed by the arithmetic unit 5, and a determination unit 18 which compares a liquid level height h2 detected at the start of a second suction operation following the first suction operation with the liquid level height h1 at the end of the first suction operation. The automatic analyzer further determines the presence or absence of a failure in the first or second suction operation according to whether the difference between both liquid level heights h1 and h2 exceeds a threshold value d set in advance. Thus, it is possible to determine whether the suction operation of the sample dispensing unit has been performed properly.
摘要翻译： 在同一样品上进行多次抽吸操作的自动分析仪具有样品分注单元9，检测样品容器8中的样品的液面的液位传感器，计算液位的运算单元5 在从第一抽吸操作开始时检测到的液面高度h0和样品吸入容积V1进行两次连续抽吸操作的第一抽吸操作结束时的高度h1，存储单元7，其存储计算出的液面高度h1 以及确定单元18，其将在第一抽吸操作之后的第二抽吸操作开始时检测到的液位高度h2与在第一抽吸操作结束时的液面高度h1进行比较。 根据两个液位高度h1和h2之间的差是否超过预先设定的阈值d，自动分析器进一步确定第一或第二抽吸操作中是否存在故障。 因此，可以确定样品分注单元的抽吸操作是否已经被适当地执行。
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公开(公告)号：EP2759828A4
公开(公告)日：2015-04-22
申请号：EP12834164
申请日：2012-09-03
IPC分类号： G01N21/51 , G01N21/82 , G01N33/543 , G01N33/545 , G01N35/00 , G01N35/02
CPC分类号： G01N33/54366 , G01N21/47 , G01N21/51 , G01N21/82 , G01N33/54313 , G01N35/025 , G01N2021/825 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2800/24
摘要： The present invention provides a device and conditions suitable for a reagent for performing latex immunoassay with a high sensitivity using a method of measuring scattered light on an automated analyzer. In an aspect of the invention, irradiation light having a wavelength in the range of 0.65 to 0.75 µm is used, and scattered light generated from a reaction solution is received at a light-receiving angle of 15° to 35° with respect to the irradiation direction of the irradiation light during the rotational movement of the reaction container 8. The reagent contains latex particles the average peak particle diameter of which ranges from 0.3 µm to 0.43 µm and to which antibodies are sensitized. The reaction solution contains latex particles at a concentration at which the absorbance to irradiation light having a wavelength of 0.7 µm is 0.25 abs to 1.10 abs, and a change in the amount of scattered light caused by the aggregation of the latex particles through antigens in a sample is measured and quantified.
摘要翻译： 本发明提供了一种适用于使用在自动分析仪上测量散射光的方法以高灵敏度进行乳胶免疫测定的试剂的装置和条件。 在本发明的一个方面中，使用波长在0.65〜0.75μm范围内的照射光，从反应溶液产生的散射光相对于照射受光角为15〜35° 在反应容器8的旋转运动期间的照射光的方向。试剂含有平均峰值粒径为0.3μm〜0.43μm的胶乳粒子，抗体被敏化。 反应溶液含有胶乳颗粒，其浓度为具有0.7μm波长的照射光的吸光度为0.25atm至1.10abs，以及由胶乳颗粒通过抗原凝集而引起的散射光量的变化 样品被测量和量化。
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公开(公告)号：EP2562547A4
公开(公告)日：2014-06-11
申请号：EP11771862
申请日：2011-04-05
CPC分类号： G01N21/272 , G01N21/78 , G01N35/00584 , G01N35/00693 , G01N2035/00465
摘要： There is provided a technique for automatically determining or predicting a line range specific to a sample that appears in a reaction curve in an automated analyzer for mixing a specimen and a reagent and measuring a change in a mixture of the specimen and the reagent with time. This invention approximates reaction curve data by a function and automatically determines a curve part at an early stage or a second stage of a reaction. The invention determines a line range not including a curve part for each sample and calculates a laboratory test value using absorbance data within the determined line range. This invention also automatically determines a start time of line at the early stage of the reaction on the basis of absorbance data obtained up to a point halfway through the reaction curve, predicts a line range on the basis of the end time of line and a planned end time of line, and calculates a predictive value on the basis of a result of the prediction.
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公开(公告)号：EP2891888A4
公开(公告)日：2016-07-06
申请号：EP13832640
申请日：2013-07-11
IPC分类号： G01N35/10
CPC分类号： G01N35/00623 , G01N35/00871 , G01N35/1016 , G01N2035/00891 , G01N2035/1018 , Y10T436/11
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公开(公告)号：EP2866022A4
公开(公告)日：2016-03-02
申请号：EP13809593
申请日：2013-05-30
CPC分类号： G01N35/1002 , G01N21/253 , G01N21/274 , G01N21/51 , G01N21/82 , G01N35/00623 , G01N35/00693 , G01N35/025 , Y10T436/115831
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公开(公告)号：EP2511699A4
公开(公告)日：2013-06-26
申请号：EP10835650
申请日：2010-11-10
发明人： LI QING , MIMURA TOMONORI , FUKUZONO SHINICHI
IPC分类号： G01N27/416 , G01N27/26 , G01N27/333
CPC分类号： G01N27/333
摘要： Electrolyte analyzers are used in a variety of ways, and problems vary from reagent deterioration due to reagent replenishment, mixing of foreign substances during reagent replenishment, electrode deterioration due to the passage of the validity date, to the operator's inputting errors. It is thus necessary to judge abnormalities of measured values resulting from such inappropriate usage, based on the fluctuation patterns of the results of daily electrolyte calibration. The invention provides a comprehensive method of precision control. The method includes the steps of: extracting the fluctuation patterns of each measured item from the results of daily electrolyte calibration; calculating the electromotive force balance ratio between the internal standard solution and high/low-concentration standard solutions as well as its fluctuation pattern; comparing all the obtained fluctuation patterns against atypical fluctuation patterns stored on the electrolyte analyzer; examining the deterioration of the electrodes and electrolyte reagents and errors in inputting the concentrations of the standard solutions; and activating an alarm.
摘要翻译： 以各种方式使用电解质分析装置，由于试剂补充，试剂补充期间的异物混合，有效期限以后的电极劣化，操作者的输入错误，试剂劣化的问题变化。 因此，基于每日电解质校准的结果的波动模式，需要判断由这种不当使用引起的测量值的异常。 本发明提供了一种综合的精密控制方法。 该方法包括以下步骤：从日常电解质校准的结果中提取每个测量项目的波动模式; 计算内标溶液与高/低浓度标准溶液之间的电动势平衡比及其波动模式; 将所有获得的波动模式与存储在电解质分析仪上的非典型波动模式进行比较; 检查电极和电解质的劣化以及输入标准溶液浓度的误差; 并启动报警。
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