公开(公告)号：EP2068153B1

公开(公告)日：2018-09-19

申请号：EP08020850.7

申请日：2008-12-01

申请人： Hitachi High-Technologies Corporation

发明人： Shibuya, Satoshi ,  Nakamura, Kazuhiro

IPC分类号： G01N35/00

CPC分类号： G01N35/00663 ,  G01N35/00594 ,  G01N35/00693 ,  G01N2035/00673

摘要： When an automatic analyzer has several reagents for an analysis item, it is time consuming to create a calibration curve factor for each reagent, which increases the burden of the operator. Applying a single calibration curve factor to a reagent set (multiple reagents) of an analysis item, however, may result in misleading analysis data due to the discrepancy in reagent production lot number and in the reactive characteristics of reagents due to reagent deterioration. The automatic analyzer of the invention stores: a predetermined period from the opening of a reagent vessel to the deterioration of the reagent; a reagent production lot number, reagent vessel unsealing time, and reagent expiration date as reagent information kept on a reagent-set-by-set basis; and relevant calibration curve factor information. The automatic analyzer judges whether a calibration curve factor for a reagent set is applicable or not to another reagent set of the analyzer with the same production number based on the predetermined period from the reagent vessel unsealing time and on the reagent expiration date.

公开(公告)号：EP3080615B1

公开(公告)日：2018-07-25

申请号：EP14812212.0

申请日：2014-12-11

申请人： Roche Diagnostics GmbH ,  F. Hoffmann-La Roche AG ,  Hitachi High-Technologies Corporation

发明人： SATTLER, Stephan ,  KRAEMER, Reinhold ,  KOMATSU, Hidenobu ,  SUZUKI, Toshio

IPC分类号： G01N35/10 ,  B01L3/00 ,  B01L9/00

CPC分类号： B01L3/523 ,  B01L3/527 ,  B01L9/00 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/045 ,  B01L2300/0672 ,  G01N35/00663 ,  G01N35/1002 ,  G01N35/1079 ,  G01N2035/00673

摘要： A reagent vessel holder for an analytical instrument is disclosed. The reagent vessel holder comprises at least one reagent vessel compartment for receiving a reagent vessel, wherein the reagent vessel compartment comprises a base and at least two lateral guiding elements, and at least one hollow needle for piercing the reagent vessel. The hollow needle is disposed on a front end of the reagent vessel compartment near the base and extends in a direction substantially parallel to the base. The lateral guiding elements are disposed so as to be adapted to slidably guide the reagent vessel in a direction substantially parallel to the direction, in which the hollow needle extends. The lateral guiding elements are adapted to receive the reagent vessel therebetween and are biased towards one another. Further, a reagent supply system for an analytical instrument and an analytical instrument comprising such a reagent vessel holder are disclosed.

公开(公告)号：EP2348299A3

公开(公告)日：2017-12-13

申请号：EP11152211.6

申请日：2011-01-26

申请人： SYSMEX CORPORATION

发明人： Nakanishi, Noriyuki ,  Ikeda, Yutaka

IPC分类号： G01N1/38 ,  G01N35/10 ,  G01N35/00

CPC分类号： G01N35/00663 ,  G01N1/38 ,  G01N35/1002 ,  G01N2035/00534 ,  G01N2035/00673

摘要： A reagent preparing apparatus for preparing reagent by mixing a concentrated reagent and a diluting liquid and supplying the prepared reagent to a clinical sample measurement apparatus which measures a clinical sample using the supplied reagent, the reagent preparing apparatus comprising: a chamber for mixing the concentrated reagent and the diluting liquid; a liquid quality measurement part for measuring a quality of the diluting liquid; and a controller for controlling a flow of the diluting liquid based on the quality of the diluting liquid measured by the liquid quality measurement part is disclosed.

公开(公告)号：EP2500731A3

公开(公告)日：2017-11-22

申请号：EP12158222.5

申请日：2012-03-06

申请人： Sysmex Corporation

发明人： Ikeda, Yutaka ,  Nakanishi, Noriyuki

IPC分类号： G01N35/00

CPC分类号： G01N35/00663 ,  G01N35/00613 ,  G01N35/00712 ,  G01N2035/00673 ,  Y10T436/12 ,  Y10T436/25

摘要： The present invention is a reagent preparation apparatus, comprising: a reagent preparation unit configured to prepare a reagent for processing a sample; a measuring unit configured to measure a property of the reagent prepared by the reagent preparation unit; a waste section configured to discard the prepared reagent when a measurement result by the measuring unit does not meet a predetermined condition; and a controller configured to control a reagent preparation operation of the reagent preparation unit, wherein the controller controls the reagent preparation unit to stop the reagent preparation operation when a number of times of discarding a reagent has reached a predetermine plurality of times.

公开(公告)号：EP2372369A3

公开(公告)日：2017-11-22

申请号：EP11160400.5

申请日：2011-03-30

申请人： Sysmex Corporation

发明人： Hamada, Yuichi ,  Fukuma, Daigo

IPC分类号： G01N35/00

CPC分类号： G01N35/00663 ,  G01N1/31 ,  G01N15/14 ,  G01N35/00712 ,  G01N35/00732 ,  G01N2035/00673 ,  G01N2035/00772 ,  G01N2035/00782 ,  G01N2035/00811 ,  G01N2035/00851 ,  G01N2035/009 ,  G01N2035/0091 ,  Y10T436/11

摘要： A sample analyzer comprising: a reagent container set section for setting a reagent container; a reader/writer configured to read out an information from the recording medium attached to the reagent container set in the reagent container set section and configured to write an information on the recording medium; a writing instruction section configured to issue an instruction to write the information on the recording medium ; and a controller configured to control the reader/writer to write the information on the recording medium attached to the reagent container set in the reagent container set section if the kind information read out from the recording medium indicates the specific reagent and the writing instruction section has issued the writing instruction.
Also, a method of writing information on a recording medium attached to a reagent container.

摘要翻译： 1.一种试样分析装置，其特征在于，具备：试剂容器设定部， 读取器/写入器，被配置为从安装在设置在试剂容器设置部分中的试剂容器上的记录介质读取信息，并被配置为将信息写入记录介质; 写入指令部分，被配置为发出将所述信息写入所述记录介质的指令; 以及控制器，如果从所述记录介质读出的所述种类信息表示所述特定试剂并且所述写入指示部具有所述特定试剂，则所述控制器被配置为控制所述读取器/写入器将所述信息写入安装到设置在所述试剂容器设置部中的试剂容器上 发出书面指示。 另外，还提供了一种在附着于试剂容器的记录介质上写入信息的方法。

公开(公告)号：EP2372368A3

公开(公告)日：2017-11-22

申请号：EP11160399.9

申请日：2011-03-30

申请人： Sysmex Corporation

发明人： Hamada, Yuichi ,  Kuwano, Keisuke

IPC分类号： G01N35/00

CPC分类号： G01N35/00712 ,  G01N1/31 ,  G01N15/14 ,  G01N35/00663 ,  G01N35/00732 ,  G01N35/1002 ,  G01N2035/00673 ,  G01N2035/00811 ,  G01N2035/009 ,  G01N2035/0091 ,  G01N2035/0405 ,  G01N2035/0436 ,  Y10T436/11

摘要： A sample analyzer comprising: a first container set section in which a first reagent container, wherein the first container set section includes a first operating section which is operated by a user when setting the first reagent container; a first detector configured to detect an operation of the first operating section; a second container set section in which a second reagent container, wherein the second container set section includes a second operating section which is operated by the user when setting the second reagent container; a second detector configured to detect an operation of the second operating section; an output section; and a controller configured to control the output section to output a predetermined notification, if the second detector detects the operation of the second operating section by the user when it is required to set the first reagent container in the first container set section.

摘要翻译： 1.一种试样分析装置，其特征在于，具备：第一容器放置部，其放置有第一试剂容器，所述第一容器放置部具有第一操作部，该第一操作部在放置所述第一试剂容器时由使用者操作; 第一检测器，被配置为检测第一操作部分的操作; 第二容器放置部分，其中第二试剂容器，其中第二容器放置部分包括第二操作部分，当设定第二试剂容器时，第二操作部分由用户操作; 第二检测器，被配置为检测第二操作部分的操作; 输出部分; 以及控制器，被配置为如果第二检测器在需要将第一试剂容器设置在第一容器放置部分中时检测到用户对第二操作部分的操作，则控制输出部分输出预定通知。

公开(公告)号：EP2410340A4

公开(公告)日：2017-11-15

申请号：EP10753534

申请日：2010-03-17

申请人： SYSMEX CORP

发明人： SHIBATA MASAHARU ,  NAKANISHI NORIYUKI

IPC分类号： G01N35/00 ,  G01N35/02 ,  G01N35/10

CPC分类号： G01N35/1081 ,  G01N35/00603 ,  G01N35/00663 ,  G01N35/00722 ,  G01N35/10 ,  G01N35/1002 ,  G01N2035/00217 ,  G01N2035/00673 ,  G01N2035/1051

摘要： A sample analyzer is provided that does not require a plurality of reagent containers containing the same type of reagent to be connected, that can continue measurement even when a reagent container becomes empty, and that allows the timing of replacement of the reagent container to be recognized suitably. A reagent storage section is provided that is connected to a reagent container containing a reagent through a fluid channel and that stores the reagent transferred from the reagent container. A message for prompting replacement of the reagent container is outputted when it is detected that the remaining amount in the reagent container is a predetermined amount or less. A message for prompting to suspend sample measurement in the measurement section is outputted when it is detected that the remaining amount in the reagent storage section is a predetermined amount or less.

公开(公告)号：EP2293083A4

公开(公告)日：2017-08-30

申请号：EP09766497

申请日：2009-05-12

申请人： HITACHI HIGH-TECHNOLOGIES CORP

发明人： SHIBA MASAKI ,  MIMURA TOMONORI ,  HAMAZUMI YUKO

IPC分类号： G01N35/00 ,  G01N35/10

CPC分类号： G01N35/1002 ,  G01N35/1011 ,  G01N2035/00673 ,  G01N2035/1025 ,  Y10T436/115831

摘要： An automatic analyzer can operate a reagent distribution operation suitable for a reagent vessel adapted to the reagent, having high reliability of analysis data and high processing ability. It is checked whether a liquid undulation prevention mechanism is present or absent in a reagent vessel at the start of an operation (steps 601 and 602). When the liquid leakage prevention mechanism is absent in the reagent vessel, the size of the opening of the reagent vessel is judged (step 604). A nozzle is inserted and lowered into the reagent vessel after one cycle from the stop of a reagent disk to judge the contact of the nozzle to the liquid surface. When the opening is larger size, a capacitance method is used (step 607). When the opening is small size, a pressure detection is used (step 608). When the liquid leakage prevention mechanism is present, the size of the opening is judged (step 604). The nozzle is inserted and lowered into the reagent vessel just after the stop of the reaction disk to judge the contact of the nozzle to the liquid surface. When the opening is larger size, a capacitance method is used (step 605). When the opening is small size, a pressure detection is used (step 606).

摘要翻译： 自动分析装置能够进行适合于试剂的试剂容器的试剂分配作业，分析数据的可靠性高，处理能力高。 在操作开始时检查试剂容器中是否存在液体波动防止机构（步骤601和602）。 当试剂容器中不存在液体泄漏防止机构时，判断试剂容器的开口尺寸（步骤604）。 从试剂盘停止一个循环后，将喷嘴插入试剂容器并下降，以判断喷嘴与液体表面的接触。 当开口较大时，使用电容方法（步骤607）。 当开口尺寸较小时，使用压力检测（步骤608）。 当存在液体泄漏防止机构时，判断开口的大小（步骤604）。 刚刚停止反应盘后，将喷嘴插入并下降到试剂容器中，以判断喷嘴与液体表面的接触。 当开口较大时，使用电容方法（步骤605）。 当开口尺寸较小时，使用压力检测（步骤606）。

公开(公告)号：EP3149475A4

公开(公告)日：2017-06-28

申请号：EP15800543

申请日：2015-05-26

申请人： SIEMENS HEALTHCARE DIAGNOSTICS INC

发明人： WANG JIANFANG ,  SPRENKLE MARK ,  INGERSOLL COLIN ,  FRYE STEPHEN

IPC分类号： G01N33/53 ,  G01N35/00 ,  G01N35/04 ,  G01N35/10

CPC分类号： G01N35/0092 ,  G01N35/00663 ,  G01N2035/00356 ,  G01N2035/00673 ,  G01N2035/0094 ,  G01N2035/0444

公开(公告)号：EP2096442A3

公开(公告)日：2017-06-14

申请号：EP09002142.9

申请日：2009-02-16

申请人： Hitachi High-Technologies Corporation

发明人： Hamazumi, Yuko ,  Mimura, Tomonori ,  Fukuyama, Yuki

IPC分类号： G01N35/00

CPC分类号： G01N35/00663 ,  G01N2035/00673

摘要： The present invention provides an index that makes it possible to use, in an automatic analyzer, an approximate expression based on a theoretical chemical reaction formula derived from reaction process data, and automatically check for apparatus abnormalities, reagent deteriorations, and improper accuracy control during each continuous or individual inspection.
Reaction process data, which is measured when the automatic analyzer determines the relationship between reaction absorbance and time, is approximated to ABS = A 0 + A 1 (1-e -kt ) by the least-squares method. The resulting reaction start point absorbance A 0 , final reaction absorbance A 1 , reaction rate constant k, and residual error, which is the aggregate sum of differences between approximate values and measured values, are then used as the index of reaction status.

摘要翻译： 本发明提供一种能够在自动分析仪中使用基于从反应过程数据导出的理论化学反应式的近似表达式的指标，并且可以自动检查装置异常，试剂恶化和每次中的不正确的精度控制 连续或个别检查。 当自动分析仪确定反应吸光度和时间之间的关系时测量的反应过程数据通过最小二乘法近似为ABS = A 0 + A 1（1-e-kt）。 然后将所得到的反应起始点吸光度A 0，最终反应吸光度A 1，反应速率常数k和剩余误​​差（即近似值和测量值之间的差值的总和）用作反应状态的指标。