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11 条记录 (耗时 0.022 秒)

    Substituted peptide derivatives
    4.
    发明公开
    Substituted peptide derivatives 失效
    取代肽衍生物

    公开(公告)号：EP0276101A3

    公开(公告)日：1989-11-23

    申请号：EP88300343.6

    申请日：1988-01-15

    申请人： ICI AMERICAS INC.

    发明人： Lewis, Joseph James ,  Perkins, Charles William ,  Trainor, Diane Amy ,  Wildonger, Richard Alan

    IPC分类号： C07K5/00 ,  A61K37/64

    CPC分类号： C07K5/06191 ,  A61K38/00

    摘要： The invention provides a series of novel substituted peptide derivatives of the formulae la, Ib and Ic (set out hereinafter) and pharmaceutically acceptable salts thereof, in which the radicals A, R 1 , R 2 and R 4 -R 9 have the meanings defined in the following specification. The compounds of formulae la, Ib, and Ic are inhbitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula la, Ib or Ic, or a pharmaceutically acceptable salt thereof and processes and intermediates for the manufacture of compounds of formulae la, Ib, and Ic.

    Selected difluoro derivatives
    8.
    发明公开
    Selected difluoro derivatives 失效
    选定的二氟衍生物

    公开(公告)号：EP0204571A2

    公开(公告)日：1986-12-10

    申请号：EP86304296.6

    申请日：1986-06-05

    申请人： ICI AMERICAS INC.

    发明人： Trainor, Diane Amy ,  Stein, Mark Morris

    IPC分类号： C07C233/30 ,  C07K5/00 ,  C07C237/04 ,  C07C271/06 ,  A61K31/48 ,  A61K31/16 ,  A61K31/27 ,  C07D207/16

    CPC分类号： C07K5/06191 ,  A61K38/00 ,  C07C271/16 ,  C07C271/18 ,  C07D207/16

    摘要： The invention discloses a series of difluoroketone mono. di- and tri-peptide derivatives of the formula la, Ib and Ic:-


    and salts thereof where appropriate, and wherein the radicals are defined hereafter in the specification. The derivatives are useful in inhibiting the action of human leukocyte elastase. There are also disclosed methods and intermediates for the manufacture of, and pharmaceutical compositions comprising, the said derivatives.

    摘要翻译： 本发明公开了一系列二氟酮单体。 式Ia，Ib和Ic的二肽和三肽衍生物： - 及其适当的盐，其中基团在下文中在说明书中定义。 该衍生物可用于抑制人类白细胞弹性蛋白酶的作用。 还公开了用于制造和包含所述衍生物的药物组合物的方法和中间体。

    Substituted peptide derivatives
    10.
    发明公开
    Substituted peptide derivatives 失效
    取代肽衍生物。

    公开(公告)号：EP0276101A2

    公开(公告)日：1988-07-27

    申请号：EP88300343.6

    申请日：1988-01-15

    申请人： ICI AMERICAS INC.

    发明人： Lewis, Joseph James ,  Perkins, Charles William ,  Trainor, Diane Amy ,  Wildonger, Richard Alan

    IPC分类号： C07K5/00 ,  A61K37/64

    CPC分类号： C07K5/06191 ,  A61K38/00

    摘要： The invention provides a series of novel substituted peptide derivatives of the formulae la, Ib and Ic (set out hereinafter) and pharmaceutically acceptable salts thereof, in which the radicals A, R 1 , R 2 and R 4 -R 9 have the meanings defined in the following specification. The compounds of formulae la, Ib, and Ic are inhbitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula la, Ib or Ic, or a pharmaceutically acceptable salt thereof and processes and intermediates for the manufacture of compounds of formulae la, Ib, and Ic.

    摘要翻译： 本发明提供了一系列新颖的式Ia，Ib和Ic的取代肽衍生物（下文阐述）及其药学上可接受的盐，其中基团A，R 1，R 2和R 2， 4> -R 9具有以下说明书中定义的含义。 式Ia，Ib和Ic的化合物是人白细胞弹性蛋白酶的抑制剂。 本发明还提供含有式Ia，Ib或Ic化合物或其药学上可接受的盐的药物组合物和用于制备式Ia，Ib和Ic化合物的方法和中间体。