-
公开(公告)号：EP1372706A2
公开(公告)日：2004-01-02
申请号：EP02713807.2
申请日：2002-03-11
IPC分类号： A61K39/02 , A61K39/108 , A61K39/12 , A61K39/095 , A61K39/116 , A61K39/385 , C07H1/00 , C07K1/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K39/36 , A61K39/39 , A61K2039/543 , A61K2039/55516 , A61K2039/55572 , A61K2039/70 , C12N2760/16134 , C12N2760/16151
摘要： An adjuvant complex composed of bacterial outer membrane protein proteosomes complexed to bacterial liposaccharide is prepared to contain the component parts under a variety of conditions. The complex can be formulated with antigenic material to form immunogenic compositions, vaccines and immunotherapeutics. An induced immune response includes protective antibodies and/or type 1 cytokines is shown for a variety of protocols.
-
公开(公告)号：EP1372706B1
公开(公告)日：2010-12-01
申请号：EP02713807.2
申请日：2002-03-11
IPC分类号： A61K39/39
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K39/36 , A61K39/39 , A61K2039/543 , A61K2039/55516 , A61K2039/55572 , A61K2039/70 , C12N2760/16134 , C12N2760/16151
摘要： An adjuvant complex composed of bacterial outer membrane protein proteosomes complexed to bacterial liposaccharide is prepared to contain the component parts under a variety of conditions. The complex can be formulated with antigenic material to form immunogenic compositions, vaccines and immunotherapeutics. An induced immune response includes protective antibodies and/or type 1 cytokines is shown for a variety of protocols.
-
3.发明授权
公开(公告)号：EP1689433B1
公开(公告)日：2010-06-30
申请号：EP04796097.6
申请日：2004-10-22
发明人： LOWELL, George, H. , BURT, David, S. , JONES, David, Hugh , ZIMMERMANN, Joseph, J. , RIOUX, Clement
IPC分类号： A61K39/39 , A61K39/112 , A61K39/095 , A61P11/06 , A61P37/00
CPC分类号： A61K39/095 , A61K35/74 , A61K39/00 , A61K39/0011 , A61K39/145 , A61K39/165 , A61K39/39 , A61K2039/55544 , A61K2039/55572 , A61K2039/57 , A61K2039/6037 , C07K14/005 , C07K14/22 , C12N2710/24143 , Y02A50/394
摘要： Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma.
-
4.发明公开
公开(公告)号：EP1689433A1
公开(公告)日：2006-08-16
申请号：EP04796097.6
申请日：2004-10-22
发明人： LOWELL, George, H. , BURT, David, S. , JONES, David, Hugh , ZIMMERMANN, Joseph, J. , RIOUX, Clement
IPC分类号： A61K39/39 , A61K39/112 , A61K39/095 , A61P11/06 , A61P37/00
CPC分类号： A61K39/095 , A61K35/74 , A61K39/00 , A61K39/0011 , A61K39/145 , A61K39/165 , A61K39/39 , A61K2039/55544 , A61K2039/55572 , A61K2039/57 , A61K2039/6037 , C07K14/005 , C07K14/22 , C12N2710/24143 , Y02A50/394
摘要： Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma.
-
-
-
搜索结果
4 条记录 (耗时 0.014 秒)
