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公开(公告)号：EP1372706A2
公开(公告)日：2004-01-02
申请号：EP02713807.2
申请日：2002-03-11
IPC分类号： A61K39/02 , A61K39/108 , A61K39/12 , A61K39/095 , A61K39/116 , A61K39/385 , C07H1/00 , C07K1/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K39/36 , A61K39/39 , A61K2039/543 , A61K2039/55516 , A61K2039/55572 , A61K2039/70 , C12N2760/16134 , C12N2760/16151
摘要： An adjuvant complex composed of bacterial outer membrane protein proteosomes complexed to bacterial liposaccharide is prepared to contain the component parts under a variety of conditions. The complex can be formulated with antigenic material to form immunogenic compositions, vaccines and immunotherapeutics. An induced immune response includes protective antibodies and/or type 1 cytokines is shown for a variety of protocols.
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2.发明公开
公开(公告)号：EP1689433A1
公开(公告)日：2006-08-16
申请号：EP04796097.6
申请日：2004-10-22
发明人： LOWELL, George, H. , BURT, David, S. , JONES, David, Hugh , ZIMMERMANN, Joseph, J. , RIOUX, Clement
IPC分类号： A61K39/39 , A61K39/112 , A61K39/095 , A61P11/06 , A61P37/00
CPC分类号： A61K39/095 , A61K35/74 , A61K39/00 , A61K39/0011 , A61K39/145 , A61K39/165 , A61K39/39 , A61K2039/55544 , A61K2039/55572 , A61K2039/57 , A61K2039/6037 , C07K14/005 , C07K14/22 , C12N2710/24143 , Y02A50/394
摘要： Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma.
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公开(公告)号：EP1372706B1
公开(公告)日：2010-12-01
申请号：EP02713807.2
申请日：2002-03-11
IPC分类号： A61K39/39
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K39/36 , A61K39/39 , A61K2039/543 , A61K2039/55516 , A61K2039/55572 , A61K2039/70 , C12N2760/16134 , C12N2760/16151
摘要： An adjuvant complex composed of bacterial outer membrane protein proteosomes complexed to bacterial liposaccharide is prepared to contain the component parts under a variety of conditions. The complex can be formulated with antigenic material to form immunogenic compositions, vaccines and immunotherapeutics. An induced immune response includes protective antibodies and/or type 1 cytokines is shown for a variety of protocols.
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4.发明授权
公开(公告)号：EP1689433B1
公开(公告)日：2010-06-30
申请号：EP04796097.6
申请日：2004-10-22
发明人： LOWELL, George, H. , BURT, David, S. , JONES, David, Hugh , ZIMMERMANN, Joseph, J. , RIOUX, Clement
IPC分类号： A61K39/39 , A61K39/112 , A61K39/095 , A61P11/06 , A61P37/00
CPC分类号： A61K39/095 , A61K35/74 , A61K39/00 , A61K39/0011 , A61K39/145 , A61K39/165 , A61K39/39 , A61K2039/55544 , A61K2039/55572 , A61K2039/57 , A61K2039/6037 , C07K14/005 , C07K14/22 , C12N2710/24143 , Y02A50/394
摘要： Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided. The immunogenic compositions, which include Proteosomes and liposaccharides, may be used to elicit or enhance a nonspecific innate immune response to, for example, treat or prevent infectious disease. In addition, after activating the innate immune system, immunogenic compositions further containing an antigen may be used to elicit a specific adaptive immune response. Furthermore, provided are compositions capable of altering hyperreactive responses or inflammatory immune responses, such as allergic reactions. Such compositions may be used as a prophylactic, or in various clinical settings to treat or prevent infectious disease (such as parasite, fungal, bacterial or viral infections), or to alter inappropriate inflammatory immune responses (such as allergic reactions or asthma.
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5.发明授权IMPROVED METHODS FOR THE PRODUCTION OF NON-COVALENTLY COMPLEXED AND MULTIVALENT PROTEOSOME SUB-UNIT VACCINES 失效改进的方法生产非共价复合的多价疫苗反对蛋白酶体亚基
公开(公告)号：EP0854729B2
公开(公告)日：2008-10-22
申请号：EP96932269.2
申请日：1996-09-18
申请人： United States Army Medical Research Materiel Command (USAMRMC) , ID Biomedical Corporation of Quebec
IPC分类号： A61K39/385 , A61K39/116 , A61K39/02 , A61K39/095 , C07K1/00 , A23J1/00 , C12N1/00 , A61K39/112
CPC分类号： A23J1/008 , A61K9/0043 , A61K9/1275 , A61K39/00 , C07K14/195 , C07K14/22 , C07K14/25 , Y02A50/476
摘要： A continuous method for preparing proteosome-amphiphilic determinant vaccines for parenteral or mucosal administration using diafiltration or ultrafiltration technology. The amphiphilic determinants include lipopolysaccharides from gram negative bacteria, e.g. S. flexneri, P. shigelloides and S. sonnei. Proteosomes are obtained from group B type 2b meningococci. The active proteosome-amphiphilic determinant complexes (non-covalent complexes) of the vaccine are formed using diafiltration or ultrafiltration to remove the detergent under non-static conditions. The use of diafiltration or ultrafiltration decreases processing time and the opportunity for contamination and further permits the use of ambient temperature and efficient scale-up. In addition, the process permits the reliable and continuous monitoring of the dializate which enhances the efficiency of the entire process. The time of dialysis for the production of a lot of vaccine is reduced from 7-10 days to less than 72 hours and usually less than 48 or 24 hours. The use of the process optimizes the presence of each antigenic component in the preparation of multivalent vaccines.
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公开(公告)号：EP1255561B1
公开(公告)日：2006-06-28
申请号：EP01910923.0
申请日：2001-02-15
发明人： BURT, David, S. , LOWELL, George, H. , WHITE, Gregory, Lee , FRIES, Louis, F., III. , TOROSSIAN, Kirkor , JONES, David, Hugh , PLANTE, Martin
IPC分类号： A61K39/39 , A61K39/145 , A61K39/12 , A61K39/295 , A61P3/12 , A61P31/16
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/543 , A61K2039/55516 , A61K2039/55555 , A61K2039/70 , C12N2760/16134 , C12N2760/16234
摘要： Improved forms of vaccines which comprise proteosomes and protein antigens are described. Vaccines which contain influenza HA as the antigen are used for illustration as to demonstrate efficacy. Improvements in the preparation of the vaccines themselves and the proteosome component are also included.
摘要翻译： 描述了包含蛋白体和蛋白抗原的疫苗的改进形式。 含有流感HA作为抗原的疫苗用于说明以显示功效。 还包括疫苗本身和蛋白体组分的制备方面的改进。
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公开(公告)号：EP1778283A2
公开(公告)日：2007-05-02
申请号：EP05851200.5
申请日：2005-06-30
发明人： BURT, David, S. , REDDISH, Mark, A. , HU, Mary, ChaoHong , LOWELL, George, H. , JONES, David, Hugh
IPC分类号： A61K39/215 , C07K14/165
CPC分类号： A61K39/215 , A61K39/12 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , A61K2039/55572 , A61K2039/57 , C07K14/005 , C12N2770/20022 , C12N2770/20034
摘要： The present disclosure relates to compositions and methods for treating or preventing coronavirus infections. For example, compositions are provided that comprise a coronavirus S protein or N protein, fragment, or variant thereof, capable of eliciting a protective humoral and/or cell-mediated immune response, which compositions are useful for treating or preventing infection by coronavirus, such as the causative agent of SARS. Also, coronavirus S protein and N protein immunogen compositions are provided that include an adjuvant, such as Proteosome or Protollin, which may be used for treating or preventing infection caused by a coronavirus, such as a SARS coronavirus.
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公开(公告)号：EP1622641A2
公开(公告)日：2006-02-08
申请号：EP04760725.4
申请日：2004-05-05
IPC分类号： A61K39/07 , A61K39/39 , A61K39/118 , A61K39/085 , A61K39/08 , A61K39/02 , A61K39/116 , A61K39/275 , A61K39/12 , A61K39/125 , A61K39/295 , A61K39/285 , A61P31/12 , A61P31/04
CPC分类号： A61K39/39 , A61K39/02 , A61K39/07 , A61K2039/6068 , A61K2039/6087
摘要： Methods for making and using therapeutic formulations of Proteosome-based immunoactive compositions are provided.
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9.发明授权IMPROVED METHODS FOR THE PRODUCTION OF NON-COVALENTLY COMPLEXED AND MULTIVALENT PROTEOSOME SUB-UNIT VACCINES 失效改进的方法生产非共价复合的多价疫苗反对蛋白酶体亚基
公开(公告)号：EP0854729B1
公开(公告)日：2004-03-10
申请号：EP96932269.2
申请日：1996-09-18
申请人： United States Army Medical Research Materiel Command (USAMRMC) , ID Biomedical Corporation of Quebec
IPC分类号： A61K39/385 , A61K39/116 , A61K39/02 , A61K39/095 , C07K1/00 , A23J1/00 , C12N1/00 , A61K39/112
CPC分类号： A23J1/008 , A61K9/0043 , A61K9/1275 , A61K39/00 , C07K14/195 , C07K14/22 , C07K14/25 , Y02A50/476
摘要： A continuous method for preparing proteosome-amphiphilic determinant vaccines for parenteral or mucosal administration using diafiltration or ultrafiltration technology. The amphiphilic determinants include lipopolysaccharides from gram negative bacteria, e.g. S. flexneri, P. shigelloides and S. sonnei. Proteosomes are obtained from group B type 2b meningococci. The active proteosome-amphiphilic determinant complexes (non-covalent complexes) of the vaccine are formed using diafiltration or ultrafiltration to remove the detergent under non-static conditions. The use of diafiltration or ultrafiltration decreases processing time and the opportunity for contamination and further permits the use of ambient temperature and efficient scale-up. In addition, the process permits the reliable and continuous monitoring of the dializate which enhances the efficiency of the entire process. The time of dialysis for the production of a lot of vaccine is reduced from 7-10 days to less than 72 hours and usually less than 48 or 24 hours. The use of the process optimizes the presence of each antigenic component in the preparation of multivalent vaccines.
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