公开(公告)号：EP2298164A2

公开(公告)日：2011-03-23

申请号：EP10176687.1

申请日：2010-09-14

Applicant: IMEC ,  Stichting IMEC Nederland

Inventor： Yazicioglu, Refet Firat ,  Penders, Julien ,  Kim, Sunyoung

IPC: A61B5/0428 ,  A61B5/0456 ,  G01R19/25

CPC classification number: A61B5/7225 ,  A61B5/04017 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0531 ,  A61B5/7207 ,  A61B5/7221 ,  A61B5/7228 ,  A61B5/7232 ,  A61B5/7239 ,  G01R19/2509

Abstract: Described herein is an analogue signal processor (ASP) application-specific integrated circuit (ASIC) (400) that can be used for remotely monitoring ECG signals of a subject that has reduced power consumption. The ASP ASIC (400) performs the functions of: ECG signal extraction with high resolution using ECG readout channel (410), feature extraction using a band-power extraction channel (420), adaptive sampling the ECG signals using an adaptive sampling analogue-to-digital converter (440), and impedance monitoring for signal integrity using an impedance monitoring channel (430). These functions enable the development of wireless ECG monitoring systems that have significantly lower power consumption but are more efficient that predecessor systems. The ASP ASIC (400) consumes 30µW from a 2V supply with compression provided by adaptive sampling providing large reductions in power consumption of a wireless ECG monitoring system of whtih the ASP ASIC (400) forms a part.

Abstract translation: 这里描述了可用于远程监测具有降低的功耗的对象的ECG信号的模拟信号处理器（ASP）专用集成电路（ASIC）（400）。 ASP ASIC（400）执行以下功能：使用ECG读出通道（410）使用高分辨率的ECG信号提取，使用带功率提取通道（420）的特征提取，使用自适应采样模拟到 数字转换器（440），以及使用阻抗监视通道（430）进行信号完整性的阻抗监视。 这些功能使得能够开发具有显着降低功耗的无线ECG监测系统，但是对于前身系统而言更有效。 ASP ASIC（400）从2V电源消耗30μW，通过自适应采样提供压缩，大大降低了ASP ASIC（400）组成的无线ECG监控系统的功耗。

公开(公告)号：EP2298164B1

公开(公告)日：2013-05-15

申请号：EP10176687.1

申请日：2010-09-14

Applicant: IMEC ,  Stichting IMEC Nederland

Inventor： Yazicioglu, Refet Firat ,  Penders, Julien ,  Kim, Sunyoung

IPC: A61B5/0428 ,  A61B5/0456 ,  G01R19/25

CPC classification number: A61B5/7225 ,  A61B5/04017 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0531 ,  A61B5/7207 ,  A61B5/7221 ,  A61B5/7228 ,  A61B5/7232 ,  A61B5/7239 ,  G01R19/2509

公开(公告)号：EP2298164A3

公开(公告)日：2011-12-21

申请号：EP10176687.1

申请日：2010-09-14

Applicant: IMEC ,  Stichting IMEC Nederland

Inventor： Yazicioglu, Refet Firat ,  Penders, Julien ,  Kim, Sunyoung

IPC: A61B5/0428 ,  A61B5/0456 ,  G01R19/25

CPC classification number: A61B5/7225 ,  A61B5/04017 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0531 ,  A61B5/7207 ,  A61B5/7221 ,  A61B5/7228 ,  A61B5/7232 ,  A61B5/7239 ,  G01R19/2509

Abstract: Described herein is an analogue signal processor (ASP) application-specific integrated circuit (ASIC) (400) that can be used for remotely monitoring ECG signals of a subject that has reduced power consumption. The ASP ASIC (400) performs the functions of: ECG signal extraction with high resolution using ECG readout channel (410), feature extraction using a band-power extraction channel (420), adaptive sampling the ECG signals using an adaptive sampling analogue-to-digital converter (440), and impedance monitoring for signal integrity using an impedance monitoring channel (430). These functions enable the development of wireless ECG monitoring systems that have significantly lower power consumption but are more efficient that predecessor systems. The ASP ASIC (400) consumes 30µW from a 2V supply with compression provided by adaptive sampling providing large reductions in power consumption of a wireless ECG monitoring system of which the ASP ASIC (400) forms a part.

公开(公告)号：EP2746891B1

公开(公告)日：2015-06-03

申请号：EP12198406.6

申请日：2012-12-20

Applicant: IMEC

Inventor： Kim, Sunyoung ,  Yazicioglu, Refet Firat

IPC: G06F1/02 ,  G06F1/03

CPC classification number: H02J3/00 ,  G06F1/022 ,  G06F1/0321 ,  Y10T307/724

公开(公告)号：EP2294979A8

公开(公告)日：2011-09-14

申请号：EP10152299.3

申请日：2010-02-01

Applicant: IMEC

Inventor： Yazicioglu, Refet Firat ,  Kim, Sunyoung

IPC: A61B5/053 ,  A61B5/0402 ,  A61B5/04 ,  A61B5/0476 ,  A61B5/0488

CPC classification number: A61B5/0531 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/7225 ,  G01R19/2509

Abstract: A method and device for continuously and simultaneously measuring an impedance signal and a biopotential signal on a biological subject's skin. The method comprises the steps of: attaching input and output electrodes to the biological subject's skin; applying a predetermined alternating current having a first frequency to the output electrodes for creating an alternating voltage signal over the input electrodes, the first frequency being above a predetermined minimum frequency; measuring an input signal from the input electrodes, the input signal comprising a biopotential signal and the alternating voltage signal; extracting from said input signal the biopotential signal; extracting from said input signal the alternating voltage signal and determining the impedance signal from the alternating voltage signal. The alternating voltage signal is extracted by amplifying and demodulating the input signal using a control signal having a frequency equal to the first frequency of the applied alternating current.

公开(公告)号：EP2591720B1

公开(公告)日：2016-04-06

申请号：EP12191680.3

申请日：2012-11-07

Applicant: IMEC

Inventor： Yazicioglu, Refet Firat ,  Kim, Sunyoung

IPC: A61B5/00 ,  A61B5/04 ,  A61B5/053 ,  H03F1/56 ,  H03F3/45 ,  H01L27/08

CPC classification number: A61B5/7214 ,  A61B5/04017 ,  A61B5/0402 ,  A61B5/0531 ,  H01L27/0811 ,  H03F1/56 ,  H03F3/45475 ,  H03F2200/213 ,  H03F2200/261 ,  H03F2203/45538 ,  H03F2203/45544 ,  H03F2203/45548 ,  H03F2203/45576

Abstract: The invention relates to a variable capacitor circuit (100) comprising a plurality of MOS capacitors (110), each MOS capacitor being implemented by a MOS transistor with the gate terminal connected to a first voltage signal (Vs) and with the drain terminal shorted with the source terminal and connected to a second voltage signal (Vc), said MOS capacitors being connected in parallel through the gate terminal connected to the first voltage signal (Vs), and being operated in a cut-off region (120) in which the equivalent capacitance (C) of each MOS capacitor remains substantially constant for variations of the first voltage signal. The invention also relates to a method for compensating a capacitance mismatch in a biomedical signal acquisition system using the described variable capacitor circuit (100).

公开(公告)号：EP2294979B1

公开(公告)日：2013-12-18

申请号：EP10152299.3

申请日：2010-02-01

Applicant: IMEC

Inventor： Yazicioglu, Refet Firat ,  Kim, Sunyoung

IPC: A61B5/053 ,  A61B5/0402 ,  A61B5/04 ,  A61B5/0476 ,  A61B5/0488

CPC classification number: A61B5/0531 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/7225 ,  G01R19/2509

Abstract: A method and device for continuously and simultaneously measuring an impedance signal and a biopotential signal on a biological subject's skin. The method comprises the steps of: attaching input and output electrodes to the biological subject's skin; applying a predetermined alternating current having a first frequency to the output electrodes for creating an alternating voltage signal over the input electrodes, the first frequency being above a predetermined minimum frequency; measuring an input signal from the input electrodes, the input signal comprising a biopotential signal and the alternating voltage signal; extracting from said input signal the biopotential signal; extracting from said input signal the alternating voltage signal and determining the impedance signal from the alternating voltage signal. The alternating voltage signal is extracted by amplifying and demodulating the input signal using a control signal having a frequency equal to the first frequency of the applied alternating current.

公开(公告)号：EP2767230A1

公开(公告)日：2014-08-20

申请号：EP14155380.0

申请日：2014-02-17

Applicant: IMEC

Inventor： Yazicioglu, Refet Firat ,  Kim, Sunyoung

IPC: A61B5/04 ,  A61B5/00 ,  G01R35/00 ,  G01R27/14

Abstract: The invention relates to a circuit (40) for impedance measurement comprising a switch matrix (43) connected to a chopper (46). The switch matrix (43) comprises a plurality of switches (S1 to S6) and is configured to receive an analogue signal (IN1, IN2). In operation, during a calibration period (PH1), the circuit (40) is configured to activate the chopper (46) and to control the switch matrix (43) in order to disconnect the received analog signal (IN1, IN2) from the chopper inputs (IN1', IN2') and to connect a voltage reference signal (VR) to the chopper inputs (IN1', IN2'). In operation, during a measurement period (PH2), the circuit (40) is configured to deactivate the chopper (46) and to control the switch matrix (43) in order to disconnect the voltage reference signal (VR) from the chopper inputs (IN1', IN2') and to connect the received analog signal (IN1, IN2) to the chopper inputs (IN1', IN2'). The invention also relates to a system and to a method for impedance measurement.

Abstract translation: 本发明涉及一种用于阻抗测量的电路（40），包括连接到斩波器（46）的开关矩阵（43）。 开关矩阵（43）包括多个开关（S1至S6），并被配置为接收模拟信号（IN1，IN2）。 在操作中，在校准周期（PH1）期间，电路（40）被配置为激活斩波器（46）并控制开关矩阵（43），以便将接收到的模拟信号（IN1，IN2）与斩波器 输入（IN1'，IN2'），并将电压参考信号（VR）连接到斩波器输入（IN1'，IN2'）。 在操作中，在测量周期（PH2）期间，电路（40）被配置为去激活斩波器（46）并控制开关矩阵（43），以便将电压参考信号（VR）与斩波器输入 IN1'，IN2'），并将接收到的模拟信号（IN1，IN2）连接到斩波器输入（IN1'，IN2'）。 本发明还涉及用于阻抗测量的系统和方法。

公开(公告)号：EP2746891A1

公开(公告)日：2014-06-25

申请号：EP12198406.6

申请日：2012-12-20

Applicant: IMEC

Inventor： Kim, Sunyoung ,  Yazicioglu, Refet Firat

IPC: G06F1/02 ,  G06F1/03

CPC classification number: H02J3/00 ,  G06F1/022 ,  G06F1/0321 ,  Y10T307/724

Abstract: A current generator (111) comprising a plurality of current cells (209_1 to 209_n, 223_1 to 223_n) connected in parallel, each current cell (209_1 to 209_n, 223_1 to 223_n) being connected to a switch (213_1 to 213_n, 227_1 to 227_n); a first summer configured to sum the output of each current cell of a first subset (207) of the plurality of current cells (209_1 to 209_n) and a second summer configured to sum the output of each current cell (223_1 to 223_n) of a second subset (221) of the plurality of current cells; a combiner (219) configured to combine the outputs of the first and second summers; and wherein each switch (213_1 to 213_n, 227_1 to 227_n) is switchable according to a sequence to generate a summed output I 1 I 2 of the current cells at a plurality of quantisation levels to generate positive and/or negative alternations of a pseudo-sinusoidal, alternating current.

Abstract translation: 电流发生器（111）包括并联连接的多个当前单元（209_1至209_n，223_1至223_n），每个当前单元（209_1至209_n，223_1至223_n）连接到开关（213_1至213_n，227_1至227_n ）; 第一加法器，被配置为对所述多个当前单元（209_1至209_n）中的第一子集（207）的每个当前单元的输出进行求和，以及第二加法器，被配置为将每个当前单元（223_1至223_n）的输出相加 所述多个当前小区的第二子集（221）; 配置为组合所述第一和第二加法器的输出的组合器（219） 并且其中每个开关（213_1至213_n，227_1至227_n）可根据序列切换，以在多个量化电平上产生当前单元的求和输出I 1 I 2，以产生伪随机数的正和负交替， 正弦，交流电。

公开(公告)号：EP2294979A1

公开(公告)日：2011-03-16

申请号：EP10152299.3

申请日：2010-02-01

Applicant: IMEC

Inventor： Yazicioglu, Refet Firat ,  Kim, Sunyoung

IPC: A61B5/053 ,  A61B5/0402 ,  A61B5/04 ,  A61B5/0476 ,  A61B5/0488

CPC classification number: A61B5/0531 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/7225 ,  G01R19/2509

Abstract: A method and device for continuously and simultaneously measuring an impedance signal and a biopotential signal on a biological subject's skin. The method comprises the steps of: attaching input and output electrodes to the biological subject's skin; applying a predetermined alternating current having a first frequency to the output electrodes for creating an alternating voltage signal over the input electrodes, the first frequency being above a predetermined minimum frequency; measuring an input signal from the input electrodes, the input signal comprising a biopotential signal and the alternating voltage signal; extracting from said input signal the biopotential signal; extracting from said input signal the alternating voltage signal and determining the impedance signal from the alternating voltage signal. The alternating voltage signal is extracted by amplifying and demodulating the input signal using a control signal having a frequency equal to the first frequency of the applied alternating current.

Abstract translation: 一种用于连续和同时测量阻抗信号和生物体的皮肤上的生物电势信号的方法和装置。 该方法包括的步骤有：将输入和输出电极对生物对象的皮肤; 施加预定的交流电流具有用于在通过输入电极交流电压信号产生第一频率的输出电极，所述第一频率为高于预定的最小频率; 从输入电极，所述输入信号包括一个生物电势信号和交流电压信号的输入信号的测量; 从所述输入信号的生物电势信号提取; 从所述输入信号中提取交流电压信号和确定性采矿从交流电压信号的阻抗信号。 交流电压信号是通过放大和使用具有等于所述交流应用的所述第一频率的频率的控制信号解调所述输入信号中提取。