公开(公告)号：EP2421376A4

公开(公告)日：2016-04-27

申请号：EP10767701

申请日：2010-04-21

申请人： IMMUNOLIGHT LLC ,  UNIV DUKE

发明人： VO-DINH TUAN ,  SCAFFIDI JONATHAN P ,  CHADA VENKATA GOPAL REDDY ,  LAULY BENOIT ,  ZHANG YAN ,  GREGAS MOLLY K ,  STANTON IAN NICHOLAS ,  STECHER JOSHUA T ,  THERIEN MICHAEL J ,  AYRES JENNIFER ,  ZHANG ZHENYUAN ,  NORTON STEPHEN JOHN ,  BOURKE FREDERIC A ,  WALDER HAROLD ,  FATHI ZAK ,  SIMMONS JOSEPH H

IPC分类号： A01N65/00 ,  A61K49/00 ,  A61L2/08 ,  A61N1/40 ,  A61N5/02 ,  A61N5/06 ,  A61P35/00 ,  A61P43/00

CPC分类号： A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ1, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.