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公开(公告)号：EP3156078B1
公开(公告)日：2020-03-04
申请号：EP16191071.6
申请日：2009-04-10
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2.发明授权FUCOIDANS AS LIGANDS FOR THE DIAGNOSIS OF DEGENERATIVE PATHOLOGIES 有权FUCOIDANE ALS LIGANDEN ZUR DIAGNOSE VON DEGENERATIVEN PATHOLOGIEN
公开(公告)号：EP2416806B8
公开(公告)日：2017-03-15
申请号：EP09786466.4
申请日：2009-04-10
发明人： MICHEL, Jean-Baptiste , LETOURNEUR, Didier , CHAUBET, Frédéric , BACHELET, Laure , ROUZET, François , MEULEMANS, Alain
IPC分类号： A61K49/00 , A61K49/04 , A61K49/08 , A61K49/22 , A61K51/04 , A61K51/00 , A61K49/12 , A61K49/18 , A61K51/06 , B82Y5/00 , A61K103/10 , G01N33/60
CPC分类号： A61K49/0002 , A61K49/0054 , A61K49/0442 , A61K49/085 , A61K49/126 , A61K49/1863 , A61K49/223 , A61K49/227 , A61K51/065 , B82Y5/00 , G01N33/534
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3.发明授权
公开(公告)号：EP2224959B1
公开(公告)日：2015-02-25
申请号：EP08859568.1
申请日：2008-12-11
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Paris Diderot - Paris 7
发明人： JANDROT-PERRUS, Martine , MUZARD, Julien , BILLIALD, Philippe , LE GULUDEC, Dominique , SARDA, Laure , MEULEMANS, Alain
IPC分类号： C07K14/705 , G01N33/68 , A61K51/08
CPC分类号： A61K51/08 , C07K14/70503
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4.发明公开
公开(公告)号：EP2416806A1
公开(公告)日：2012-02-15
申请号：EP09786466.4
申请日：2009-04-10
发明人： MICHEL, Jean-Baptiste , LETOURNEUR, Didier , CHAUBET, Frédéric , BACHELET, Laure , ROUZET, François , MEULEMANS, Alain
CPC分类号： A61K49/0002 , A61K49/0054 , A61K49/0442 , A61K49/085 , A61K49/126 , A61K49/1863 , A61K49/223 , A61K49/227 , A61K51/065 , B82Y5/00 , G01N33/534
摘要： The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis.
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5.发明公开
公开(公告)号：EP2224959A1
公开(公告)日：2010-09-08
申请号：EP08859568.1
申请日：2008-12-11
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Paris Diderot - Paris 7
发明人： JANDROT-PERRUS, Martine , MUZARD, Julien , BILLIALD, Philippe , LE GULUDEC, Dominique , SARDA, Laure , MEULEMANS, Alain
CPC分类号： A61K51/08 , C07K14/70503
摘要： The present invention relates to diagnostic imaging and in particular to the diagnostic imaging of fibrosis. More particularly, the present invention provides a polypeptides, cyclic polypeptides and pharmaceutical compositions suitable for the non-invasive visualization of fibrosis. The polypeptide of the invention may comprise an amino acid sequence consisting of: X1-X2-M-H-G-L-X7-L-X9-X10-D-E wherein amino acid X1 is R, F or P; amino acid X2 is F or V; amino acid X7 is Q, H or L; amino acid X9 is W or G and amino acid X10 is A or D.
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