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公开(公告)号：EP3156078B1
公开(公告)日：2020-03-04
申请号：EP16191071.6
申请日：2009-04-10
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公开(公告)号：EP3624832A1
公开(公告)日：2020-03-25
申请号：EP18724555.0
申请日：2018-05-15
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Paris Diderot - Paris 7 , Université Paris XIII Paris-Nord , Assistance Publique-Hôpitaux de Paris (APHP) , Fondation Ophthalmologique Adolphe De Rothschild
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3.发明公开
公开(公告)号：EP2416806A1
公开(公告)日：2012-02-15
申请号：EP09786466.4
申请日：2009-04-10
发明人： MICHEL, Jean-Baptiste , LETOURNEUR, Didier , CHAUBET, Frédéric , BACHELET, Laure , ROUZET, François , MEULEMANS, Alain
CPC分类号： A61K49/0002 , A61K49/0054 , A61K49/0442 , A61K49/085 , A61K49/126 , A61K49/1863 , A61K49/223 , A61K49/227 , A61K51/065 , B82Y5/00 , G01N33/534
摘要： The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis.
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4.发明公开AGENTS FOR THE MOLECULAR IMAGING OF SERINE-PROTEASE IN HUMAN PATHOLOGIES 审中-公开代理商人类病理检查对丝氨酸蛋白酶的分子成像
公开(公告)号：EP2646058A1
公开(公告)日：2013-10-09
申请号：EP11794452.0
申请日：2011-12-05
发明人： MICHEL, Jean-Baptiste , ROUZET, François , LEGULUDEC, Dominique , PORAS, Hervé , FOURNIE-ZALUSKI, Marie-Claude , ROQUES, Bernard
CPC分类号： A61K51/088 , A61K49/0004 , A61K49/14 , A61K51/048 , A61K51/0482 , A61K51/08 , C07K5/1024
摘要： The present invention is directed to the use of an irreversible ligand of a serine protease selected from the group consisting of leukocyte elastase, thrombin, tissue plasminogen activator (t-PA) and plasmin for the molecular imaging of said serine protease and the diagnosis of pathophysiological conditions associated with said serine protease activity.
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5.发明授权FUCOIDANS AS LIGANDS FOR THE DIAGNOSIS OF DEGENERATIVE PATHOLOGIES 有权FUCOIDANE ALS LIGANDEN ZUR DIAGNOSE VON DEGENERATIVEN PATHOLOGIEN
公开(公告)号：EP2416806B8
公开(公告)日：2017-03-15
申请号：EP09786466.4
申请日：2009-04-10
发明人： MICHEL, Jean-Baptiste , LETOURNEUR, Didier , CHAUBET, Frédéric , BACHELET, Laure , ROUZET, François , MEULEMANS, Alain
IPC分类号： A61K49/00 , A61K49/04 , A61K49/08 , A61K49/22 , A61K51/04 , A61K51/00 , A61K49/12 , A61K49/18 , A61K51/06 , B82Y5/00 , A61K103/10 , G01N33/60
CPC分类号： A61K49/0002 , A61K49/0054 , A61K49/0442 , A61K49/085 , A61K49/126 , A61K49/1863 , A61K49/223 , A61K49/227 , A61K51/065 , B82Y5/00 , G01N33/534
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