专利检索 ap:("INSERM (Institut National de la Santé et de la Recherche Médicale)" OR "Université Paris 13") AND inv:"CHAUBET, Frédéric" 第 1 页

1.

发明授权
FUCOIDANS AS LIGANDS FOR THE DIAGNOSIS OF DEGENERATIVE PATHOLOGIES 有权
标题翻译： FUCOIDANE ALS LIGANDEN ZUR DIAGNOSE VON DEGENERATIVEN PATHOLOGIEN

公开(公告)号：EP2416806B8

公开(公告)日：2017-03-15

申请号：EP09786466.4

申请日：2009-04-10

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Paris 13

发明人： MICHEL, Jean-Baptiste , LETOURNEUR, Didier , CHAUBET, Frédéric , BACHELET, Laure , ROUZET, François , MEULEMANS, Alain

IPC分类号： A61K49/00 , A61K49/04 , A61K49/08 , A61K49/22 , A61K51/04 , A61K51/00 , A61K49/12 , A61K49/18 , A61K51/06 , B82Y5/00 , A61K103/10 , G01N33/60

CPC分类号： A61K49/0002 , A61K49/0054 , A61K49/0442 , A61K49/085 , A61K49/126 , A61K49/1863 , A61K49/223 , A61K49/227 , A61K51/065 , B82Y5/00 , G01N33/534

2.

发明公开
FUCOIDANS AS LIGANDS FOR THE DIAGNOSIS OF DEGENERATIVE PATHOLOGIES 有权
标题翻译：岩藻依聚糖的配体诊断PATHOLOGIES退行性

公开(公告)号：EP2416806A1

公开(公告)日：2012-02-15

申请号：EP09786466.4

申请日：2009-04-10

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale)

发明人： MICHEL, Jean-Baptiste , LETOURNEUR, Didier , CHAUBET, Frédéric , BACHELET, Laure , ROUZET, François , MEULEMANS, Alain

IPC分类号： A61K49/00 , A61K49/04 , A61K49/08 , A61K49/22 , A61K51/04 , A61K51/00

CPC分类号： A61K49/0002 , A61K49/0054 , A61K49/0442 , A61K49/085 , A61K49/126 , A61K49/1863 , A61K49/223 , A61K49/227 , A61K51/065 , B82Y5/00 , G01N33/534

摘要： The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis.