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公开(公告)号:EP3271335B8
公开(公告)日:2019-03-27
申请号:EP16710161.7
申请日:2016-03-16
申请人: INSERM (Institut National de la Santé et de la Recherche Médicale) , Centre Hospitalier Régional et Universitaire de Lille (CHRU) , Université de Lille
发明人: SERGEANT, Nicolas , BUEE, Luc , MELNYK, Patricia , GAY, Marion , LE FUR, Nicolas
IPC分类号: C07D219/12 , A61K31/435 , A61P25/28
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公开(公告)号:EP3271335B1
公开(公告)日:2018-12-26
申请号:EP16710161.7
申请日:2016-03-16
申请人: INSERM (Institut National de la Santé et de la Recherche Médicale) , Centre Hospitalier Régional et Universitaire de Lille (CHRU) , Université de Lille 2 Droit et Santé
发明人: SERGEANT, Nicolas , BUEE, Luc , MELNYK, Patricia , GAY, Marion , LE FUR, Nicolas
IPC分类号: C07D219/12 , A61K31/435 , A61P25/28
CPC分类号: C07D219/12
摘要: The present invention relates to the compound having Formula (I) or pharmaceutically acceptable salts or solvates thereof, and its use in treating and/or preventing a Tauopathy.
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公开(公告)号:EP3013824B8
公开(公告)日:2018-11-21
申请号:EP14733220.9
申请日:2014-06-27
申请人: Alzprotect , Université de Lille , INSERM - Institut National de la Santé et de la Recherche Médicale
发明人: MELNYK, Patricia , CARATO, Pascal , BURLET, Stéphane , NGUYEN, Emilie , VERWAERDE, Philippe , SERGEANT, Nicolas , ESTRELLA, Cécilia
IPC分类号: C07D471/04 , C07D491/048 , A61K31/437 , A61P25/28
CPC分类号: C07D471/04
摘要: The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.
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4.CARBOLINE COMPOUNDS USABLE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权
标题翻译: 可用于治疗神经退行性疾病的咔啉化合物公开(公告)号:EP3013824B1
公开(公告)日:2018-05-16
申请号:EP14733220.9
申请日:2014-06-27
申请人: Alzprotect , Université de Lille 2 Droit et Santé , INSERM - Institut National de la Santé et de la Recherche Médicale
发明人: MELNYK, Patricia , CARATO, Pascal , BURLET, Stéphane , NGUYEN, Emilie , VERWAERDE, Philippe , SERGEANT, Nicolas , ESTRELLA, Cécilia
IPC分类号: C07D471/04 , C07D491/048 , A61K31/437 , A61P25/28
CPC分类号: C07D471/04
摘要: The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.
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公开(公告)号:EP3820862A1
公开(公告)日:2021-05-19
申请号:EP19739966.0
申请日:2019-07-10
申请人: INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Lille , Centre Hospitalier Régional et Universitaire de Lille
发明人: MELNYK, Patricia , TAUTOU, Marie , EVRARD, Caroline , DESCAMPS, Florian , EL BAKALI, Jamal , GAY, Marion , RENAULT, Nicolas , SERGEANT, Nicolas , CARATO, Pascal , VINGTDEUX, Valérie
IPC分类号: C07D401/14 , C07D413/14 , C07D401/12 , C07D211/06 , A61P25/28 , A61K31/435 , A61K31/497
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公开(公告)号:EP3042206B1
公开(公告)日:2019-06-19
申请号:EP14766928.7
申请日:2014-09-04
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7.CARBOLINE COMPOUNDS USABLE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 有权
标题翻译: CARBOLIN-VERBINDUNGEN ZUR VERWENDUNG BEI DER BEHANDLUNG NEURODEGENERATIVER ERKRANKUNGEN公开(公告)号:EP3013824A1
公开(公告)日:2016-05-04
申请号:EP14733220.9
申请日:2014-06-27
申请人: Alzprotect , Université de Lille 2 Droit et Santé , INSERM - Institut National de la Santé et de la Recherche Médicale
发明人: MELNYK, Patricia , CARATO, Pascal , BURLET, Stéphane , NGUYEN, Emilie , VERWAERDE, Philippe , SERGEANT, Nicolas , ESTRELLA, Cécilia
IPC分类号: C07D471/04 , C07D491/048 , A61K31/437 , A61P25/28
CPC分类号: C07D471/04
摘要: The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.
摘要翻译: 本发明涉及式(A)化合物或其药学上可接受的盐,溶剂合物,包合物,水合物或多晶型物及其用途。
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公开(公告)号:EP3042206A1
公开(公告)日:2016-07-13
申请号:EP14766928.7
申请日:2014-09-04
申请人: INSERM - Institut National de la Santé et de la Recherche Médicale , Université de Droit et de la Santé de Lille 2 , Centre Hospitalier Regional Universitaire de Lille
CPC分类号: G01N33/689 , G01N2333/91215
摘要: The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to methods and kits for determining the human sperm quality.
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公开(公告)号:EP3145529A1
公开(公告)日:2017-03-29
申请号:EP15716781.8
申请日:2015-04-14
申请人: Association Institut de Myologie , Centre National de la Recherche Scientifique , INSERM - Institut National de la Santé et de la Recherche Médicale , Université Pierre et Marie Curie (Paris 6)
CPC分类号: A61K38/1709 , A61K48/005 , A61K48/0075
摘要: The present invention relates to compositions and methods for treating myotonic dystrophy.
摘要翻译: 本发明涉及用于治疗强直性肌营养不良症的组合物和方法。
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10.NEW ANTIBODIES SPECIFIC OF THE -AMYLOID PEPTIDES AND THEIR USES AS DIAGNOSTIC AGENTS OR DRUGS 审中-公开
标题翻译: 新的β-淀粉样肽特异性抗体及其作为诊断剂或药物公开(公告)号:EP2205633A1
公开(公告)日:2010-07-14
申请号:EP08844119.1
申请日:2008-10-24
申请人: Innogenetics N.V. , INSERM (Institut National de la Santé et de la Recherche Médicale) , Sanofi-Aventis , Innogenetics N.V.
发明人: VANMECHELEN, Eugeen , GROGNET, Pierre , SERGEANT, Nicolas , GOMPEL, Marie , DELACOURTE, André , BUEE, Luc , PRADIER, Laurent , BLANCHARD-BREGEON, Véronique
IPC分类号: C07K16/18 , A61K39/395 , G01N33/577 , C12N5/18 , C07K14/47 , A61P25/28
CPC分类号: C07K16/18 , A61K2039/505 , C07K14/4711 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要: The present invention relates to a monoclonal antibody which specifically binds to the N-terminal region of Aβ8-X peptide, x being comprised from 11 to 42, and recognises neither Aβ1-40 nor Aβ1-42 and which presents a high affinity with respect to Aβ8-X peptide, such as determined by an immunological complex formation between the monoclonal antibody and the peptide Aβ8-X.
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