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1.发明公开NEW ANTIBODIES SPECIFIC OF THE -AMYLOID PEPTIDES AND THEIR USES AS DIAGNOSTIC AGENTS OR DRUGS 审中-公开新的β-淀粉样肽特异性抗体及其作为诊断剂或药物
公开(公告)号：EP2205633A1
公开(公告)日：2010-07-14
申请号：EP08844119.1
申请日：2008-10-24
申请人： Innogenetics N.V. , INSERM (Institut National de la Santé et de la Recherche Médicale) , Sanofi-Aventis , Innogenetics N.V.
发明人： VANMECHELEN, Eugeen , GROGNET, Pierre , SERGEANT, Nicolas , GOMPEL, Marie , DELACOURTE, André , BUEE, Luc , PRADIER, Laurent , BLANCHARD-BREGEON, Véronique
IPC分类号： C07K16/18 , A61K39/395 , G01N33/577 , C12N5/18 , C07K14/47 , A61P25/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/4711 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to a monoclonal antibody which specifically binds to the N-terminal region of Aβ8-X peptide, x being comprised from 11 to 42, and recognises neither Aβ1-40 nor Aβ1-42 and which presents a high affinity with respect to Aβ8-X peptide, such as determined by an immunological complex formation between the monoclonal antibody and the peptide Aβ8-X.
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公开(公告)号：EP1250600B1
公开(公告)日：2006-10-11
申请号：EP01909655.1
申请日：2001-01-18
申请人： Innogenetics N.V.
CPC分类号： C07K14/4711 , A61K38/00 , G01N33/6896 , G01N2500/00 , G01N2800/28 , G01N2800/2821 , G01N2800/52 , Y10S435/975 , Y10T436/10
摘要： The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the ratio of phospho-tau (181)/ total tau in said individual. The present invention further provides a phospho-peptide for standardization in a method of the invention.
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公开(公告)号：EP1250600A2
公开(公告)日：2002-10-23
申请号：EP01909655.1
申请日：2001-01-18
申请人： INNOGENETICS N.V.
CPC分类号： C07K14/4711 , A61K38/00 , G01N33/6896 , G01N2500/00 , G01N2800/28 , G01N2800/2821 , G01N2800/52 , Y10S435/975 , Y10T436/10
摘要： The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the ratio of phospho-tau (181)/ total tau in said individual. The present invention further provides a phospho-peptide for standardization in a method of the invention.
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4.发明公开MONOCLONAL ANTIBODIES SPECIFIC FOR AN EPITOPE OF A PARTICULAR SUBCLASS OR FORM OF PHOSPHORYLATED TAU, HYBRIDOMAS SECRETING THEM, ANTIGEN RECOGNITION OF THESE ANTIBODIES AND THEIR APPLICATIONS 失效针对表位某师或磷酸化tau蛋白的单克隆抗体，杂交瘤THESE塞泽尔肾，抗原识别这些抗体及其用途
公开(公告)号：EP0772634A1
公开(公告)日：1997-05-14
申请号：EP95928494.0
申请日：1995-07-31
申请人： INNOGENETICS N.V.
CPC分类号： C07K16/18 , C07K14/4711 , C12N9/12 , Y10S435/975 , Y10S436/811
摘要： The present invention relates to a monoclonal antibody which forms an immunological complex with a phosphorylated epitope of a particular subclass or form of phosphorylated tau protein without forming an immunological complex with (i) fetal tau or (ii) biopsy or autopsy derived brain material from patients having died or suffering from diseases in which NFT is not a pathological hallmark. The invention also relates to a process for diagnosing brain diseases involving monoclonal antibodies of the invention. The invention also relates to a region of the tau molecule which is specifically recognized by the monoclonal antibodies of the invention. The invention also relates to kinases or phosphorylases which specifically react with the epitope recognized by these monoclonal antibodies as well as to a method for screening compounds which interfere with the activity of these kinases and phosphorylases.
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5.发明公开MONOCLONAL ANTIBODIES SPECIFIC FOR PHF-TAU, HYBRIDOMAS SECRETING THEM, ANTIGEN RECOGNITION BY THESE ANTIBODIES AND THEIR APPLICATIONS 失效反对PHF-TAU，杂交瘤THESE退休，识别抗原的单克隆抗体这些抗体及其用途
公开(公告)号：EP0737208A1
公开(公告)日：1996-10-16
申请号：EP95903798.0
申请日：1994-12-14
申请人： Innogenetics N.V.
CPC分类号： C07K16/18 , C07K14/4711
摘要： The present invention relates more particularly to a monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to abnormally phosphorylated tau (PHF-tau) residing in the region spanning positions (143-254), and with said monoclonal antibody being characterized by the fact that it is capable of specifically detecting abnormally phosphorylated tau protein (PHF-tau) in cerebrospinal fluid (CSF).
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公开(公告)号：EP1295129B1
公开(公告)日：2010-04-07
申请号：EP01957875.6
申请日：2001-06-21
申请人： Innogenetics N.V.
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2821 , G01N2800/2835
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公开(公告)号：EP1112500B1
公开(公告)日：2004-09-22
申请号：EP99968716.3
申请日：1999-09-07
申请人： INNOGENETICS N.V.
发明人： HULSTAERT, Frank , VANMECHELEN, Eugeen , VANDERSTICHELE, Hugo , VAN DE VOORDE, André , VAN GOOL, Stefaan
IPC分类号： G01N33/68 , G01N33/574
CPC分类号： G01N33/6896 , G01N33/574
摘要： The present invention provides a new method for the early diagnosis of CNS damage in an individual, said CNS damage being caused by space-occupying lesions of the CNS, by invasion or metastasis of the CNS, by organisms, by anoxia or ischemia, by chemical agents, by physical agents, or by a combination of these mechanisms. This new method comprises the step of determining and/or quantifying the level of tau in said individual and comparing it to the level of tau in control healthy individuals.
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8.发明公开METHOD FOR THE PREDICTION, DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF ALZHEIMER S DISEASE 有权方法预测，老年痴呆症的诊断和诊断比较
公开(公告)号：EP1625403A1
公开(公告)日：2006-02-15
申请号：EP04730881.2
申请日：2004-05-03
申请人： Innogenetics N.V.
发明人： VANDERSTICHELE, Hugo , VANMECHELEN, Eugeen , BLENNOW, Kaj , DE MEYER, Geert , KOSTANJEVECKI, Vesna
IPC分类号： G01N33/68
CPC分类号： C07K16/18 , G01N33/54306 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： Methods are provided for the prediction, diagnosis and differential diagnosis of Alzheimer's disease. More particularly, a method is provided to determine whether a subject that does not show any clinical signs of Alzheimer's disease has a likelihood to develop Alzheimer's disease. Further a method is provided for the diagnosis of subjects suffering from Alzheimer's disease and/or for the differential diagnosis of subjects suffering from Alzheimer's disease versus subjects suffering from other dementias such as dementia with Lewy bodies. The methods are based on the determination of the ratio of specific Aβ peptides.
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公开(公告)号：EP1095278B1
公开(公告)日：2005-12-07
申请号：EP99934543.2
申请日：1999-06-29
申请人： Innogenetics N.V.
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2835 , G01N2800/52
摘要： The present invention relates to new methods for the specific detection, quantification and/or differential diagnosis of neurodegeneration in an individual making use of a combination assay detecting at least three neurological markers in one or more body fluids of said individual, the type and degree of neurodegeneration being reflected in the quantitative changes in the level of all of said neurological markers compared to the control sample. The present invention also relates to methods for the detection of Rab3a, SNAP25 and alpha -synuclein in cerebrospinal fluid and to the use of these methods in a combination assay for specific detection, quantification and/or differential diagnosis of neurodegeneration.
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公开(公告)号：EP1295129A1
公开(公告)日：2003-03-26
申请号：EP01957875.6
申请日：2001-06-21
申请人： INNOGENETICS N.V.
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2800/28 , G01N2800/2821 , G01N2800/2835
摘要： The present invention provides a method for the differential diagnosis of an individual suffering from Alzheimer's disease versus and individual suffering from another neurological disease. More specifically, the present invention provides a method for the differential diagnosis of an individual suffering from Alzheimer's disease versus an individual suffering from dementia with Lewy bodies, versus an individual suffering from Parkinson's disease without dementia, versus an individual suffering from multi-system atrophy and/or versus an individual suffering from progressive supranuclear palsy, said method characterized that phospho-tau is used as a neurological marker.
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