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1.发明公开METHODS FOR SELECTING COMPETENT OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME 有权一种用于选择运算卵母细胞和胚胎运算具有高潜力的怀孕
公开(公告)号：EP2643478A1
公开(公告)日：2013-10-02
申请号：EP11794430.6
申请日：2011-11-24
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Centre Hospitalier Regional Universitaire De Montpellier , Universite de Montpellier 1
发明人： HAMAMAH, Samir , ASSOU, Said
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12N2310/141 , C12N2320/10 , C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to a method for selecting a competent oocyte or a competent embryo by determining the expression level of specific microRNA species in a body fluid or in cumulus cells.
摘要翻译： 本发明涉及一种用于在体液或在卵丘细胞通过确定性采矿选择主管卵母细胞或主管胚特异性微小RNA种类的表达水平的方法。
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2.发明公开
公开(公告)号：EP2726630A1
公开(公告)日：2014-05-07
申请号：EP12730558.9
申请日：2012-06-29
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Universite de Montpellier 1 , Centre Hospitalier Universitaire de Montpellier
IPC分类号： C12Q1/68
CPC分类号： C12N5/0605 , C12N5/0682 , C12N2501/115 , C12N2533/54 , C12Q1/6881
摘要： The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to a method determining the developmental stage of human cumulus cells issues from MII oocyte.
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3.发明公开METHODS FOR ASSESSING ENDOMETRIAL RECEPTIVITY OF A PATIENT AFTER CONTROLLED OVARIAN HYPERSTIMULATION 有权评估方法子宫内膜容受性患者进行控制性超排卵
公开(公告)号：EP2768976A2
公开(公告)日：2014-08-27
申请号：EP12775259.0
申请日：2012-10-22
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Universite de Montpellier 1 , Centre Hospitalier Regional Universitaire De Montpellier
发明人： HAMAMAH, Samir , HAOUZI, Delphine
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2565/513 , C12Q2600/158 , C12Q2600/166
摘要： Disclosed herein are methods and kits for assessing the endometrial receptivity of a patient after controlled ovarian hyperstimulation. More particularly, provided herein is a method for assessing the endometrial receptivity of a patient after controlled ovarian hyperstimulation, comprising a step consisting of measuring the expression level of at least one gene selected from fifteen genes in an endometrial biopsy sample obtained from the patient wherein the genes are FGFBP1, MUC20, TMPRSS3, PRUNE2, HES2, MGST1, ERRFI1, EDN1, SLC17A7, MET, CPT1B, DCDC2, LRRC39, IL18RAP, and FOXP1.
摘要翻译： 公开在为assesing控制性超促排卵后，病人的子宫内膜容受性的方法和试剂盒。 更具体地说，在提供的是用于assesing控制性超排卵后的患者的子宫内膜容受，包括步骤由......组成测量在从所述患者worin所获得的子宫内膜活检样品中的15个基因中选择的至少一种基因的表达水平的方法 基因是FGFBP1，MUC20，TMPRSS3，PRUNE2，HES2，MGST1，ERRFI1，EDN1，SLC17A7，MET，CPT1B，DCDC2，LRRC39，IL18RAP，和FOXP1。
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4.发明授权METHODS FOR SELECTING OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME 有权选择妊娠结局潜力大的卵母细胞和能力母体的方法
公开(公告)号：EP2419526B1
公开(公告)日：2016-03-30
申请号：EP10713218.5
申请日：2010-04-09
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Montpellier , Centre Hospitalier Universitaire de Montpellier
发明人： HAMAMAH, Samir , DE VOS, John , ASSOU, Said
IPC分类号： C12Q1/68 , G01N33/569
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/158 , G01N33/689
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5.发明公开METHODS FOR SELECTING COMPETENT OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME 有权一种用于选择运算卵母细胞和胚胎运算具有高潜力的怀孕
公开(公告)号：EP3037554A1
公开(公告)日：2016-06-29
申请号：EP16151156.3
申请日：2010-04-09
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , UNIVERSITE DE MONTPELLIER , Centre Hospitalier Universitaire de Montpellier
发明人： HAMAMAH, Samir , DE VOS, John , ASSOU, Said
IPC分类号： C12Q1/68 , G01N33/68 , G01N33/569
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/158 , G01N33/689
摘要： The present invention relates to a method for selecting an oocyte that when fertilized produces a viable embryo with a high implantation rate leading to pregnancy by measuring, in a cumulus cell surrounding said oocyte, the expression level of 45 specific genes which consist in WNT6, LRCH4, PAX8, CABP4, PDE5A, BCL2L11, PCK1, TCF20, SLAMF6, EPOR, CACNG6, NLRP1, PECAM1, NOS1, ATF3, KRTAP8, GRIK5, SLC24A3, SLC5A12, SLCA10A2, SLCO1A2, SLC25A5, MG29, NLGN2, PRKACA, FOSB, SIAT6, LOXL2, PRF1, ADPRH, APBB3, EGR3, CNR2, IFITM1, PLA2G5, CAMTA1, SOX4, NFIB, NFIC, RBMS1, G0S2, FAT3, SLC40A1, GPC6 and IGF1R
摘要翻译： 本发明涉及一种方法，用于选择的卵母细胞的速率并当受精产生一个与高注入通过测量导致妊娠一个存活的胚胎，在卵丘细胞包围所述卵母细胞，在45个特定基因的表达水平，其由在WNT6，LRCH4 ，PAX8，CABP4，PDE5A，BCL2L11，PCK1，TCF20，SLAMF6，EPOR，CACNG6，NLRP1，PECAM1，NOS1，ATF3，KRTAP8，GRIK5，SLC24A3，SLC5A12，SLCA10A2，SLCO1A2，SLC25A5，MG29，NLGN2，PRKACA，FOSB，SIAT6 ，LOXL2，PRF1，ADPRH，APBB3，EGR3，CNR2，IFITM1，PLA2G5，CAMTA1，SOX4，NFIB，NFIC，RBMS1，GOS2启动，FAT-3，SLC40A1，GPC6和IGF1R
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6.发明授权METHODS FOR SELECTING COMPETENT OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME 有权一种用于选择运算卵母细胞和胚胎运算具有高潜力的怀孕
公开(公告)号：EP2630500B1
公开(公告)日：2015-09-30
申请号：EP11776143.7
申请日：2011-10-18
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Centre Hospitalier Universitaire de Montpellier , Université de Montpellier
发明人： HAMAMAH, Samir , ASSOU, Said , DE VOS, John
CPC分类号： C12Q1/6881 , A61B17/43 , C12Q1/66 , C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , C12Q2600/16 , G01N33/5005 , G01N33/689 , G01N33/6893 , G01N2800/367
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7.发明公开METHODS FOR SELECTING OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME 有权一种用于选择运算卵母细胞和胚胎运算具有高潜力的怀孕
公开(公告)号：EP2419526A1
公开(公告)日：2012-02-22
申请号：EP10713218.5
申请日：2010-04-09
发明人： HAMAMAH, Samir , DE VOS, John , ASSOU, Said
IPC分类号： C12Q1/68 , G01N33/569
CPC分类号： C12Q1/6881 , C12Q2600/156 , C12Q2600/158 , G01N33/689
摘要： The present invention relates to a method for selecting a competent oocyte or a competent embryo.
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公开(公告)号：EP2603581B1
公开(公告)日：2019-07-17
申请号：EP11741581.0
申请日：2011-08-11
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Montpellier , Centre Hospitalier Universitaire de Montpellier
发明人： HAMAMAH, Samir , ASSOU, Said
IPC分类号： C12N5/073 , C12N5/0735 , A61D19/00
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9.发明公开METHODS FOR SELECTING COMPETENT OOCYTES AND COMPETENT EMBRYOS WITH HIGH POTENTIAL FOR PREGNANCY OUTCOME 有权一种用于选择运算卵母细胞和胚胎运算具有高潜力的怀孕
公开(公告)号：EP2630500A1
公开(公告)日：2013-08-28
申请号：EP11776143.7
申请日：2011-10-18
发明人： HAMAMAH, Samir , ASSOU, Said , DE VOS, John
CPC分类号： C12Q1/6881 , A61B17/43 , C12Q1/66 , C12Q1/6876 , C12Q2600/124 , C12Q2600/158 , C12Q2600/16 , G01N33/5005 , G01N33/689 , G01N33/6893 , G01N2800/367
摘要： The present invention relates to a method for selecting a competent oocyte or a competent embryo.
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公开(公告)号：EP2603581A1
公开(公告)日：2013-06-19
申请号：EP11741581.0
申请日：2011-08-11
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de Montpellier I , Centre Hospitalier Universitaire de Montpellier
发明人： HAMAMAH, Samir , ASSOU, Said
IPC分类号： C12N5/073 , C12N5/0735 , A61D19/00
CPC分类号： C12N5/0603 , A61D19/00 , C12N5/0604 , C12N5/0605 , C12N5/0606 , C12N2502/02 , C12N2517/10
摘要： The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to a novel human embryo co-culture system to improve human embryo growth in vitro and, consequently, increase pregnancy rates in infertile women undergoing in vitro fertilization (IVF) treatment. More particularly, the present invention relates to a method of growing an embryo to a blastocyst stage of development comprising the step of coculturing said embryo in the presence of a population of cumulus cells.
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