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    Nanobodies suitable for neuron degeneration therapy
    2.
    发明公开
    Nanobodies suitable for neuron degeneration therapy 审中-公开
    NanokörperfürNeurondegenerationstherapie

    公开(公告)号：EP2995624A1

    公开(公告)日：2016-03-16

    申请号：EP14306388.1

    申请日：2014-09-09

    申请人： INSTITUT PASTEUR

    发明人： Prehaud, Christophe ,  Lafon, Monique ,  Lafaye, Pierre

    IPC分类号： C07K16/18

    CPC分类号： C07K16/18 ,  A61K47/48538 ,  C07K2317/22 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2319/22 ,  C07K2319/33 ,  C12N2760/20122

    摘要： The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and / or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g. neurons, astrocytes and microglial cells).

    摘要翻译： 本发明处于通过血脑屏障传递给脑细胞的分子的领域。 本发明涉及一种新颖的基于多肽的载体，其允许有效递送效应肽，跨越血脑屏障的神经元细胞，以及用于生产和测试这种载体的方法，包括用于测试 这种分子穿过血脑屏障和/或分子对血脑屏障的毒性和/或已经与靶向人脑细胞（例如神经元，星形胶质细胞和小胶质细胞）交叉的分子的能力。

    High MAST2-affinity polypeptides and uses thereof
    3.
    发明公开
    High MAST2-affinity polypeptides and uses thereof 有权
    多肽线虫MAST2-Affinitätund deren Verwendungen

    公开(公告)号：EP2592091A1

    公开(公告)日：2013-05-15

    申请号：EP11306454.7

    申请日：2011-11-08

    申请人： Institut Pasteur ,  Centre National de la Recherche Scientifique ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

    发明人： Prehaud, Christophe ,  Lafon, Monique ,  Wolff, Nicolas ,  Khan, Zakir ,  Terrien, Elouan

    IPC分类号： C07K14/435

    CPC分类号： C12Q1/6883 ,  C07K14/005 ,  C07K14/435 ,  C07K2319/02 ,  C07K2319/05 ,  C07K2319/70 ,  C12N7/00 ,  C12N2799/027 ,  C12Q1/70 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/5023 ,  G01N33/5038 ,  G01N33/5058 ,  G01N2333/705

    摘要： The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of which are S and W, and the last four residues of which are Q, T, R and L, said polypeptides presenting a high affinity for the PDZ domain of the human MAST2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions comprising the same. The invention is also directed to the use of said polypeptides, polynucleotides, vectors, lentiviral particles, cells and compositions in the treatment and/or prevention of a disease, disorder or condition, which alters the Central Nervous System (CNS) and/or the Peripheral Nervous System (PNS). The invention also concerns molecular signatures of cellular genes to determine the neurosurvival and/or neuroprotection activity of a molecule.

    摘要翻译： 本发明涉及含有以MAST-2结合结构域结束的细胞质结构域的多肽，其为11至13个残基，其前两个残基为S和W，最后4个残基为Q，T，R和L 所述多肽对人MAST2蛋白的PDZ结构域具有高亲和力。 本发明还涉及多核苷酸，载体，慢病毒颗粒，细胞以及包含其的组合物。 本发明还涉及使用所述多肽，多核苷酸，载体，慢病毒颗粒，细胞和组合物来治疗和/或预防疾病，病症或病症，其改变中枢神经系统（CNS）和/或 外周神经系统（PNS）。 本发明还涉及细胞基因的分子特征，以确定分子的神经营养和/或神经保护活性。

    Use of mecamylamine in the treatment of pathogen-infected patients with central nervous system disorder
    4.
    发明公开
    Use of mecamylamine in the treatment of pathogen-infected patients with central nervous system disorder 审中-公开
    在感染病菌的患者与CNS病症治疗使用的美加明

    公开(公告)号：EP2535046A1

    公开(公告)日：2012-12-19

    申请号：EP11170446.6

    申请日：2011-06-17

    申请人： Institut Pasteur

    发明人： Chopy, Damien, Maximilien ,  Lafon, Monique

    IPC分类号： A61K31/13 ,  A61P31/14

    CPC分类号： A61K31/13 ,  A61K2300/00

    摘要： The invention relates to mecamylamine or a composition comprising mecamylamine, for use in the therapeutic treatment of an animal or a human patient presenting with a disorder of the central nervous system, said animal or patient being suspected of having an infection by a pathogen which triggers immune unresponsiveness, or for use to restore immune response in said animal or said human patient. In a particular embodiment, the invention is directed to mecamylamine or a composition comprising mecamylamine, for use to treat established rabies in a human patient or to treat a human patient presenting with clinical symptoms of rabies.

    摘要翻译： 本发明涉及美加明或组合物，包括美加明，用于在动物或人类患者与中枢神经系统病症呈现的治疗性治疗中使用，所述动物或患者由病原体触发免疫被怀疑患有感染的 无应答，或用于恢复在动物免疫应答或所述人类患者。 在特定实施例中，本发明涉及美加明或包含美加明的组合物，用于治疗狂犬病建立在人类患者或用于治疗人类患者狂犬病临床症状呈现。

    Products useful for the treatment of malignant neoplasms of the human nervous system
    6.
    发明公开
    Products useful for the treatment of malignant neoplasms of the human nervous system 审中-公开
    Zur Behandlung恶性肿瘤Nerplensmen des menschlichen NervensystemsnützlicheProdukte

    公开(公告)号：EP2581384A1

    公开(公告)日：2013-04-17

    申请号：EP11306318.4

    申请日：2011-10-11

    申请人： Institut Pasteur ,  Centre National de la Recherche Scientifique ,  Université Pierre et Marie Curie - Paris 6

    发明人： Wolff, Nicolas ,  Lafon, Monique ,  Babault, Nicolas

    IPC分类号： C07K14/145 ,  C07K14/705

    CPC分类号： C07K7/08 ,  A61K9/127 ,  A61K38/10 ,  A61K45/06 ,  C07K14/005 ,  C07K14/705 ,  C12N2760/20122 ,  C12N2760/20133

    摘要： The application provides products, which may trigger pro-apoptotic or pro-death effects on neoplastic cells and/or tissues of the human nervous system, more particularly on neoplastic cells and/or tissues of the human CNS. The products of the application can be used as anti-proliferative or tumoricid agents in the treatment and/or palliation and/or prevention of neoplasms of the human nervous system, more particularly of glioblastoma or brain stem glioma. Therefore, the application also relates to compositions, such as pharmaceutical compositions or drugs, which comprise at least one of said products, as well as to the biotechnological and medical applications of said products and compositions.

    摘要翻译： 该应用提供了产品，其可以触发对人类神经系统的肿瘤细胞和/或组织的促凋亡或促死亡作用，更特别是对人CNS的肿瘤细胞和/或组织。 该应用的产品可以用作抗增殖剂或肿瘤剂，用于治疗和/或缓解和/或预防人类神经系统肿瘤，更特别是胶质母细胞瘤或脑干胶质瘤。 因此，本申请还涉及包含至少一种所述产品的组合物，例如药物组合物或药物，以及所述产品和组合物的生物技术和医学应用。

    Neuron generation, regeneration and protection
    7.
    发明公开
    Neuron generation, regeneration and protection 审中-公开
    Neuronenerzeugung，-erneuerung und -schutz

    公开(公告)号：EP2239330A1

    公开(公告)日：2010-10-13

    申请号：EP09290257.6

    申请日：2009-04-07

    申请人： Institut Pasteur

    发明人： Prehaud, Christophe ,  Lafon, Monique ,  Schnell, Matthias Johannes

    IPC分类号： C12N15/47 ,  C12N15/86 ,  C07K14/145 ,  A61K38/17 ,  A61K48/00

    CPC分类号： C07K14/005 ,  A61K35/13 ,  A61K35/766 ,  A61K38/00 ,  A61K38/162 ,  C12N2760/20122 ,  Y02A50/465

    摘要： The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth promoting effect. The invention further demonstrates that this neurite outgrowth promoting effect is due to the cytoplasmic tail of said non-apoptotic rabies virus G proteins, more particularly to their PDZ-BS, which shows a single-point mutation compared to the one of apoptotic rabies virus G proteins. The invention provides means for inducing and/or stimulating neurite outgrowth, which are useful in inducing neuron differentiation, for example for the treatment of a neoplasm of the nervous system, as well as in regenerating impaired neurons, for example for the treatment of a neurodegenerative disease, disorder or condition or in the treatment of a microbial infection, or in protecting neurons from neurotoxic agents or oxidative stress.

    摘要翻译： 本发明证明，与凋亡性狂犬病病毒G蛋白相反，某些非凋亡性狂犬病病毒G蛋白，如CVS-NIV菌株的G蛋白具有神经突增生促进作用。 本发明进一步表明，这种神经突增生促进作用是由于所述非凋亡性狂犬病病毒G蛋白的细胞质尾巴，更特别是其PDZ-BS，其与凋亡性狂犬病病毒G相比显示单点突变 蛋白质。 本发明提供用于诱导和/或刺激神经突生长的方法，其可用于诱导神经元分化，例如用于治疗神经系统的肿瘤，以及再生受损的神经元，例如用于治疗神经变性 疾病，病症或状况或治疗微生物感染，或保护神经元免受神经毒性物质或氧化应激。