-
公开(公告)号：EP2995949A1
公开(公告)日：2016-03-16
申请号：EP14306389.9
申请日：2014-09-09
发明人： Prehaud, Christophe , Lafon, Monique , Ceccaldi, Pierre-Emmanuel , Afonso, Philippe , Lafaye, Pierre
CPC分类号： G01N33/5082 , C12M21/08 , C12M23/34 , C12M25/02 , C12M29/04 , C12N5/0622 , C12N5/069 , C12N5/0691 , C12N2502/28 , G01N33/5014 , G01N33/5058 , G01N33/5064
摘要： The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and / or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g. neurons, astrocytes and microglial cells).
摘要翻译： 本发明处于通过血脑屏障传递给脑细胞的分子的领域。 本发明涉及一种新颖的基于多肽的载体，其允许有效递送效应肽，跨越血脑屏障的神经元细胞，以及用于生产和测试这种载体的方法，包括用于测试 这种分子穿过血脑屏障和/或分子对血脑屏障的毒性和/或已经与靶向人脑细胞（例如，神经元，星形胶质细胞和小胶质细胞）交叉的分子的能力。
-
2.发明公开Oligopeptide and methods for producing conjugates thereof 审中-公开Oligopeptid和Verfahren zur Herstellung von Konjugaten davon
公开(公告)号：EP2873680A1
公开(公告)日：2015-05-20
申请号：EP13306554.0
申请日：2013-11-13
发明人： Lafaye, Pierre , Bay, Sylvie , Delatour, Benoît , Dhenain, Marc , Duyckaerts, Charles , Li, Tengfei , Vandesquille, Matthias , Czech, Christian , Grueninger, Fiona
CPC分类号： C07K16/18 , A61K49/0032 , A61K49/0058 , A61K49/085 , A61K49/16 , A61K51/1093 , C07K2317/22 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/92 , C07K2319/00 , G01N33/6854 , G01N2333/4709
摘要： The present invention relates to an oligopeptide and conjugates thereof. The present invention also relates to the use of these oligopeptide conjugates for treating or diagnosing disorders mediated by amyloid β deposits. Finally, the present invention also relates to a coupling method for obtaining oligopeptide coupled with a substance of interest (functional conjugates).
摘要翻译： 本发明涉及寡肽及其缀合物。 本发明还涉及这些寡肽缀合物用于治疗或诊断由淀粉样蛋白²沉积物介导的病症的用途。 最后，本发明还涉及用于获得与感兴趣物质（功能性共轭物）偶联的寡肽的偶联方法。
-
3.发明公开
公开(公告)号：EP2871189A1
公开(公告)日：2015-05-13
申请号：EP13306527.6
申请日：2013-11-07
发明人： Girard-Blanc, Christine , Krey, Thomas , Vasiliauskaite, Ieva , Nato, Farida , Lafaye, Pierre , Dartevelle, Sylvie , Rey, Felix
CPC分类号： C07K16/1292 , C07K2317/22 , C07K2317/34 , G01N33/6854
摘要： The present invention provides novel antibodies recognizing the so-called "Strep-Tag II" peptide, to its preparation and to uses thereof. Anti-strep tag antibodies are useful for quick purification but also for sensitive detection and tight immobilization of Strep-Tag II fusion proteins.
摘要翻译： 本发明提供了识别所谓的“Strep-Tag II”肽的新型抗体的制备及其用途。 抗Strep标签抗体可用于快速纯化，也可用于灵敏检测和严格固定Strep-Tag II融合蛋白。
-
4.发明公开
公开(公告)号：EP2995624A1
公开(公告)日：2016-03-16
申请号：EP14306388.1
申请日：2014-09-09
申请人： INSTITUT PASTEUR
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K47/48538 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2319/22 , C07K2319/33 , C12N2760/20122
摘要： The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and / or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g. neurons, astrocytes and microglial cells).
摘要翻译： 本发明处于通过血脑屏障传递给脑细胞的分子的领域。 本发明涉及一种新颖的基于多肽的载体，其允许有效递送效应肽，跨越血脑屏障的神经元细胞，以及用于生产和测试这种载体的方法，包括用于测试 这种分子穿过血脑屏障和/或分子对血脑屏障的毒性和/或已经与靶向人脑细胞（例如神经元，星形胶质细胞和小胶质细胞）交叉的分子的能力。
-
5.发明公开Camelid single-domain antibody directed against amyloid bêta and methods for producing conjugates thereof 审中-公开针对β淀粉状蛋白的单结构域骆驼抗体和方法，用于制备它们的结合物
公开(公告)号：EP2873679A1
公开(公告)日：2015-05-20
申请号：EP13306553.2
申请日：2013-11-13
发明人： Lafaye, Pierre , Bay, Sylvie , Delatour, Benoît , Dhenain, Marc , Duyckaerts, Charles , Li, Tengfei , Vandesquille, Matthias , Czech, Christian , Grueninger, Fiona
CPC分类号： C07K16/18 , A61K47/6803 , A61K47/6843 , A61K49/0058 , A61K49/108 , A61K49/16 , A61K51/1018 , A61K2039/505 , C07K2317/22 , C07K2317/51 , C07K2317/565 , C07K2317/569 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/387 , G01N2800/52
摘要： The present invention relates to variable domain of a camelid heavy-chain antibodies directed to amyloid β and conjugates thereof. The present invention also relates to the use of these antibody conjugates for treating or diagnosing disorders mediated by amyloid β deposits.
摘要翻译： 本发明涉及针对淀粉样蛋白²和缀合物骆驼科动物重链抗体的可变结构域。 因此，本发明涉及使用合成抗体偶联物可用于治疗或诊断由淀粉样蛋白沉积物²介导的病症。
-
6.发明公开Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing conjugates thereof 审中-公开针对β淀粉状蛋白的单结构域磷酸化tau蛋白和方法，用于制备它们的结合物
公开(公告)号：EP2899208A1
公开(公告)日：2015-07-29
申请号：EP14152928.9
申请日：2014-01-28
发明人： Lafaye, Pierre , Bay, Sylvie , Delatour, Benoït , Dhenain, Marc , Duyckaerts, Charles , Li, Tengfei , Vandesquille, Matthias , Czech, Christian , Grueninger, Fiona
CPC分类号： C07K16/18 , A61K49/0041 , A61K49/0058 , A61K49/16 , A61K51/10 , C07K2317/22 , C07K2317/34 , C07K2317/569 , G01N33/6896 , G01N2333/47 , G01N2440/14 , G01N2800/2821
摘要： The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
摘要翻译： 本发明涉及针对磷酸化的tau蛋白和缀合物骆驼科动物重链抗体的可变结构域。 因此，本发明涉及使用合成结构域或结合物用于治疗或诊断由神经原纤维缠结，神经纤维网线或营养不良的轴突,:如tau蛋白病介导的病症。
-
7.发明公开Neutralizing antibodies directed against Hepatitis C virus ectodomain glycoprotein E2 审中-公开Neue neutralisierendeAntikörper，die sich gegen den丙型肝炎病毒丰富
公开(公告)号：EP2716655A1
公开(公告)日：2014-04-09
申请号：EP12187318.6
申请日：2012-10-04
申请人： INSTITUT PASTEUR
发明人： Krey, Thomas , Tarr, Alexander W. , Lafaye, Pierre , Ball, Jonathan K. , Rey, Felix A. , Jestin, Jean-Luc
CPC分类号： C07K16/109 , C07K2299/00 , C07K2317/22 , C07K2317/33 , C07K2317/34 , C07K2317/569 , C07K2317/76 , G01N33/5767
摘要： The present invention relates to antibodies or fragments thereof, such as variable domains of camelid heavy-chain antibodies, directed against Hepatitis C virus glycoprotein E2, and uses thereof for preparing therapeutic or diagnostic agents.
摘要翻译： 本发明涉及针对丙型肝炎病毒糖蛋白E2的抗体或其片段，例如骆驼重链抗体的可变结构域，及其用于制备治疗剂或诊断剂的用途。
-
8.发明公开Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins 审中-公开变量Domänenvon Schwerketten-Antikörpern，死亡的gegen GFAPs丰富
公开(公告)号：EP2143735A1
公开(公告)日：2010-01-13
申请号：EP08290683.5
申请日：2008-07-10
申请人： Institut Pasteur
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： A61K51/1018 , A61K2039/505 , A61K2039/54 , A61K2039/543 , A61K2039/545 , C07K16/18 , C07K16/3053 , C07K2317/22 , C07K2317/569 , C07K2317/92 , C12N5/0622
摘要： The present invention relates to variable domains of camelid heavy-chain antibodies directed against a glial fibrillary acidic protein and uses thereof for preparing therapeutic or diagnostic agents.
摘要翻译： 本发明涉及针对胶质纤维酸性蛋白的骆驼重链抗体的可变结构域及其用于制备治疗剂或诊断剂的用途。
-
9.发明公开Use of a camelid single-domain antibody for detecting an oligomeric form of an amyloid beta peptide and its applications 审中-公开使用单域骆驼抗体对淀粉样β肽及其应用的寡聚形式的发现
公开(公告)号：EP2009445A1
公开(公告)日：2008-12-31
申请号：EP07290812.2
申请日：2007-06-29
发明人： Rougeon, François , Lafaye, Pierre
CPC分类号： C07K14/4711 , A61K2039/505 , C07K16/18 , C07K2317/22 , C07K2317/92 , G01N33/6896 , G01N2800/2821 , G01N2800/387
摘要： Use of camelid single-domain antibodies for detecting an oligomeric form of the amyloid β peptide 42 and their therapeutic and diagnostic applications.
摘要翻译： 对于淀粉样肽²42个及其治疗和诊断应用的低聚体形式的检测使用骆驼科动物的单域抗体。
-
10.发明公开Use of VHH antibodies for the preparation of peptide vectors for delivering a substance of interest and their applications 审中-公开VHH的使用抗体用于制备肽载体的一个相关物质的输送和应用的肽的载体的
公开(公告)号：EP2008666A1
公开(公告)日：2008-12-31
申请号：EP07290811.4
申请日：2007-06-29
发明人： Rougeon, Francois , Lafaye, Pierre
IPC分类号： A61K47/48
CPC分类号： C07K16/18 , A61K47/6803 , A61K47/6843 , A61K51/1018 , C07K2317/22 , C07K2317/569 , C07K2317/622 , C07K2317/92
摘要： Use of a variable fragment of a camelid single-chain antibody (VHH antibody) for the preparation of a peptide vector for delivering a substance of interest across the blood-brain barrier.
摘要翻译： 使用用于制备肽载体的用于跨血脑屏障递送感兴趣的物质的骆驼科动物的单链抗体（VHH抗体）的可变片段。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.021 秒)
