-
1.发明公开
公开(公告)号：EP1290018A2
公开(公告)日：2003-03-12
申请号：EP01938317.3
申请日：2001-05-23
申请人： Societé d'Etudes et de Developpment des Antigenes Combinatoires - SEDAC Therapeutics , Centre National de la Recherche Scientifique ( CNRS) , Institut Pasteur De Lille
CPC分类号： C07K14/005 , C07K1/00 , C07K1/047 , C12N2770/24222
摘要： The invention concerns the designing and synthesis of immunogenic peptides corresponding to restricted regions of the proteins of virus involving an immune response to T cells and convergent combinatory peptide libraries derived from said regions. The invention is particular applicable to hepatitis C virus and useful for producing vaccine preparations against same.
-
2.发明授权PROCEDE DE COUPLAGE, EN SOLUTION, ENTRE UN PEPTIDE ET AU MOINS UN AUTRE COMPOSE ET SES APPLICATIONS 有权FOR之间的肽和至少另一个连接在溶液中，离合器形式及其用途
公开(公告)号：EP1206482B1
公开(公告)日：2003-09-24
申请号：EP00958701.5
申请日：2000-08-18
CPC分类号： C07K7/06 , A61K39/00 , C07K1/006 , C07K1/1075 , C07K1/1077 , C07K7/08 , C07K14/001
-
3.发明授权PROCEDE DE COUPLAGE, EN SOLUTION, ENTRE UN PEPTIDE ET UN VECTEUR LIPOPHILE ET SES APPLICATIONS 有权PROCESS FOR IN之间的肽和亲脂性化合物溶液的离合器，及其用途
公开(公告)号：EP1315739B1
公开(公告)日：2004-08-18
申请号：EP01967454.8
申请日：2001-09-07
申请人： INSTITUT PASTEUR DE LILLE Etablissement Public , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： C07K1/107 , A61K47/48 , C07C233/03 , C07D209/32 , A61K39/395
CPC分类号： C07D263/04 , A61K38/00 , A61K47/54 , C07C235/74 , C07K1/1077
-
">4.发明授权DISPOSITIF DE PRESENTATION DE POLYPEPTIDES, UTILISABLE COMME "PUCE" POUR LA DETECTION MINIATURISEE DE MOLECULES. 有权DEVICE FORPOLYPEPTIDPRÄSENTATION，用作传感器芯片检测分子的小型化
公开(公告)号：EP1390751B1
公开(公告)日：2011-11-30
申请号：EP02740818.6
申请日：2002-05-27
发明人： MELNYK, Oleg , GRAS-MASSE, Hélène , OLIVIER, Christophe , DURAND, Jean-Olivier , AURIAULT, Claude , DUBURCQ, Xavier , BOUZIDI, Ahmed , GARCIA, Jean-Michel , EL-MAHDI, Ouafâa
IPC分类号： G01N33/543 , G01N33/68
CPC分类号： G01N33/54353
摘要： The invention relates to a device for presenting peptides or proteins which can be used as a polypeptide chip for miniaturized detection of molecules which structurally or functionally complement said polypeptides. Said device consists of a flat support where polypeptides are covalently bound. The link between the polypeptides and the support results from the formation of a semicarbazone link. The semicarbazone link is a specific result of the reaction between polypeptides having an aldehyde or ketone function; and a support functionalized by semicarbazide groupings. The invention also relates to a method for preparing the supports and attaching the polypeptides to these supports in addition to the use of said devices thus obtained as polypeptide chips .
-
公开(公告)号：EP1171405B1
公开(公告)日：2007-01-03
申请号：EP00920852.1
申请日：2000-04-20
IPC分类号： C07B41/06 , C07B61/00 , C07K1/107 , G01N33/547 , C12Q1/68
CPC分类号： C40B99/00 , C07B41/06 , C07B61/00 , C07D307/24 , C07K1/042 , C40B40/04 , C40B40/10 , C40B50/14 , Y02P20/55
摘要： The invention concerns a functionalised solid support for the synthesis of compounds comprising at least an alpha -oxoaldehyde function, its method for preparation and its uses, in particular for preparing a bank of organic compounds, a diagnostic reagent, a microtitration plate and a biochip, such as a DNA chip. The invention also concerns a method for the synthesis of organic compounds comprising at least an alpha -oxoaldehyde function and alpha -oxoaldehyde peptides obtained by said method.
-
6.发明公开UTILISATION DES ACIDES QUINIQUE, SHIKIMIQUE ET DE LEURS DERIVES POUR LA PREPARATION DE LIGANDS DU RECEPTEUR DU MANNOSE 审中-公开中国和莽草酸及其衍生物为配体甘露糖受体的制备中使用
公开(公告)号：EP1200462A2
公开(公告)日：2002-05-02
申请号：EP00956573.0
申请日：2000-07-28
发明人： GRANDJEAN, Cyrille , MELNYK, Oleg , GRAS-MASSE, Hélène , ANGYALOSI, Gerhild , ROMMENS, Corinne , AURIAULT, Claude
IPC分类号： C07K14/00 , C07K7/02 , C07K5/023 , C07K5/037 , A61K38/04 , A61K38/16 , G01N33/68 , A61K31/19
CPC分类号： C07K5/0202 , C07K5/0215 , C07K7/02 , C07K14/001
摘要： The invention concerns the use of quinic, shimic acids and their derivatives for preparing mannose receptor ligands, the resulting ligands and the uses of said ligands, in particular for preparing medicines and, more particularly for preparing vaccines and medicines for vectoring an active principle to target cells expressing the mannose receptor or a receptor related thereto, for transfecting DNA and RNA sequences and numerous other uses in gene therapy, and for preparing laboratory reagents, in particular diagnostic reagents.
-
7.发明授权MICELLES MIXTES DE LIPOPEPTIDES POUR L'INDUCTION D'UNE REPONSE IMMUNITAIRE 有权MISCMICELLEN关闭脂肽诱导免疫应答
公开(公告)号：EP1035866B1
公开(公告)日：2006-05-17
申请号：EP98958314.1
申请日：1998-12-02
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT PASTEUR DE LILLE
发明人： GRAS-MASSE, Hélène , BOSSUS, Marc , LIPPENS, Guy , WIERUSZESKI, Jean-Michel , TARTAR, André , GUILLET, Jean-Gérard , BOURGAULT-VILLADA, Isabelle
CPC分类号： A61K39/015 , A61K9/1075 , A61K39/12 , A61K39/385 , A61K2039/55577 , A61K2039/6018 , A61K2039/70 , C12N2740/15034 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334 , Y02A50/412
摘要： The invention concerns mixed micelles or micro-aggregates for inducing an immune response containing at least: a first lipopeptide comprising a CTL epitope and at least a first lipid motif; and a second lipopeptide comprising at least an auxiliary T epitope and at least a lipid motif, whereof the type can be different from the first lipopeptide motif. Said micelles can be used as medicines and vaccines.
-
">8.发明公开DISPOSITIF DE PRESENTATION DE POLYPEPTIDES, UTILISABLE COMME "PUCE" POUR LA DETECTION MINIATURISEE DE MOLECULES. 有权DEVICE FORPOLYPEPTIDPRÄSENTATION，用作传感器芯片检测分子的小型化
公开(公告)号：EP1390751A2
公开(公告)日：2004-02-25
申请号：EP02740818.6
申请日：2002-05-27
申请人： Societe d'Etude et de Developpement des Antigenes, Combinatoires - Sedac Therapeutics , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITE DE LILLE II
发明人： MELNYK, Oleg , GRAS-MASSE, Hélène , OLIVIER, Christophe , DURAND, Jean-Olivier , AURIAULT, Claude , DUBURCQ, Xavier , BOUZIDI, Ahmed , GARCIA, Jean-Michel , EL-MAHDI, Ouafâa
IPC分类号： G01N33/543 , G01N33/68
CPC分类号： G01N33/54353
摘要： The invention relates to a device for presenting peptides or proteins which can be used as a polypeptide chip for miniaturized detection of molecules which structurally or functionally complement said polypeptides. Said device consists of a flat support where polypeptides are covalently bound. The link between the polypeptides and the support results from the formation of a semicarbazone link. The semicarbazone link is a specific result of the reaction between polypeptides having an aldehyde or ketone function; and a support functionalized by semicarbazide groupings. The invention also relates to a method for preparing the supports and attaching the polypeptides to these supports in addition to the use of said devices thus obtained as polypeptide chips .
-
9.发明授权LIPOPEPTIDES INDUCTEURS DE CYTOTOXICITE T LYMPHOCYTAIRE PORTANT AU MOINS UN EPITOPE T AUXILIAIRE, ET LEURS UTILISATIONS POUR LA VACCINATION 有权脂肽细胞毒性T淋巴细胞ANSWER引诱，与至少一个表位T辅助细胞，及其作为疫苗
公开(公告)号：EP1068226B1
公开(公告)日：2005-04-20
申请号：EP99911884.7
申请日：1999-04-06
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT PASTEUR DE LILLE
发明人： LE GAL, Frédérique, Anne , GUILLET, Jean, Gérard , GAHERY-SEGARD, Hanne , GRAS-MASSE, Hélène , MELNYK, Oleg , TARTAR, André
IPC分类号： C07K14/025 , C07K14/16 , A61K39/295 , A61K47/48
CPC分类号： C07K14/005 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K47/646 , A61K2039/55566 , A61K2039/6018 , A61K2039/6037 , A61K2039/627 , A61K2039/70 , C12N2710/20022 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , Y02A50/412
-
公开(公告)号：EP1171405A1
公开(公告)日：2002-01-16
申请号：EP00920852.1
申请日：2000-04-20
IPC分类号： C07B41/06 , C07B61/00 , C07K1/107 , G01N33/547 , C12Q1/68
CPC分类号： C40B99/00 , C07B41/06 , C07B61/00 , C07D307/24 , C07K1/042 , C40B40/04 , C40B40/10 , C40B50/14 , Y02P20/55
摘要： The invention concerns a functionalised solid support for the synthesis of compounds comprising at least an α-oxoaldehyde function, its method for preparation and its uses, in particular for preparing a bank of organic compounds, a diagnostic reagent, a microtitration plate and a biochip, such as a DNA chip. The invention also concerns a method for the synthesis of organic compounds comprising at least an α-oxoaldehyde function and α-oxoaldehyde peptides obtained by said method.
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.025 秒)
