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1.发明公开AMINO-PROPYLENE-GLYCOL DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 审中-公开氨基丙二醇衍生物，工艺用于生产药物组合物适当地使用该
公开(公告)号：EP2786982A1
公开(公告)日：2014-10-08
申请号：EP12808109.8
申请日：2012-07-05
发明人： HAN, Weijuan , ZHANG, Haijing , WANG, Xiaojian , JIN, Jing , LI, Gang , ZHANG, Yi , XIAO, Qiong , ZHOU, Wanqi , CHEN, Xiaoguang , YIN, Dali
IPC分类号： C07C215/38 , C07C217/48 , C07C217/56 , C07C323/32 , C07D263/32 , C07D207/333 , C07D307/28 , C07D277/24 , C07D277/26 , A61K31/137 , A61K31/421 , A61K31/4164 , A61K31/40 , C07C31/44 , A61K31/341 , A61K31/505 , A61K31/426 , A61P37/02 , A61P37/04 , A61P37/06
CPC分类号： C07D307/52 , A61K31/137 , A61K31/341 , A61K31/40 , A61K31/4164 , A61K31/421 , A61K31/426 , A61K31/505 , C07C217/64 , C07C217/72 , C07C233/18 , C07C233/47 , C07C323/32 , C07C323/62 , C07C2601/02 , C07D207/333 , C07D213/38 , C07D233/64 , C07D239/26 , C07D263/32 , C07D277/24 , C07D277/26 , C07D277/28 , C07D307/38 , C07D307/42
摘要： Disclosed are immune-modulators of formula (I), the preparation method thereof, a pharmaceutical composition containing the immune-modulators, and the use of the pharmaceutical composition as a drug, especially as an immune-modulating drug. The compound can be used in immune disorders and immune suppression, and can be used in treating hypo-immunity, rejection after organ transplantation and auto-immune disease.
摘要翻译： 本发明公开了式（I）的免疫调节剂，其制备方法，含有该免疫调节剂，和用作药物的药物组合物，作为爱特别是免疫调节药物的药物组合物。 该化合物可以以免疫疾病和免疫抑制中使用，并且可以在器官移植和自身免疫性疾病治疗之后防免疫力，拒绝使用。
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2.发明公开
公开(公告)号：EP4169917A1
公开(公告)日：2023-04-26
申请号：EP22213583.2
申请日：2017-12-26
发明人： XU, Heng , CHEN, Xiaoguang , LIN, Songwen , JI, Ming , JIN, Jing , WU, Deyu , WANG, Yangchun , LV, Yuanhao
IPC分类号： C07D405/14 , C07D401/14 , C07D401/04 , A61K31/517 , A61K31/5377
摘要： The invention relates to quinazoline compounds, the preparation method, use, and the pharmaceutical composition thereof. The said quinazoline compounds, which are represented by Formula (I), are phosphatidylinositol 3-kinase (PI3K) inhibitors, and can be applied to prevent and/or treat PI3K activity-related diseases, such as cancer, immune diseases, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders or neurological diseases.
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3.发明公开
公开(公告)号：EP4169918A1
公开(公告)日：2023-04-26
申请号：EP22213594.9
申请日：2017-12-26
发明人： XU, Heng , CHEN, Xiaoguang , LIN, Songwen , JI, Ming , JIN, Jing , WU, Deyu , WANG, Yangchun , LV, Yuanhao
IPC分类号： C07D405/14 , C07D401/14 , C07D401/04 , C07D409/14 , A61K31/517 , A61K31/5377
摘要： The invention relates to quinazoline compounds, the preparation method, use, and the pharmaceutical composition thereof. The said quinazoline compounds, which are represented by Formula (I), are phosphatidylinositol 3-kinase (PI3K) inhibitors, and can be applied to prevent and/or treat PI3K activity-related diseases, such as cancer, immune diseases, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders or neurological diseases.
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4.发明公开
公开(公告)号：EP3560921A1
公开(公告)日：2019-10-30
申请号：EP17886474.0
申请日：2017-12-26
发明人： XU, Heng , CHEN, Xiaoguang , LIN, Songwen , JI, Ming , JIN, Jing , WU, Deyu , WANG, Yangchun , LV, Yuanhao
IPC分类号： C07D405/14 , C07D401/14 , C07D401/04 , A61K31/517 , A61K31/5377
摘要： The invention relates to quinazoline compounds, the preparation method, use, and the pharmaceutical composition thereof. The said quinazoline compounds, which are represented by Formula (I), are phosphatidylinositol 3-kinase (PI3K) inhibitors, and can be applied to prevent and/or treat PI3K activity-related diseases, such as cancer, immune diseases, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders or neurological diseases.
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