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1.发明授权DERIVES DE 5-SULFANYL-4H-1,2,4-TRIAZOLES POUR TRAITER LES DÉSORDRES ASSOCIÉS À LA SOMATOSTATINE 有权5 - 硫烷基 - 4H-1,2,4-三唑衍生物和它们用于治疗somatostatins介导的疾病的使用
公开(公告)号：EP1465880B1
公开(公告)日：2009-08-05
申请号：EP02796876.7
申请日：2002-11-27
申请人： IPSEN PHARMA
IPC分类号： C07D249/12 , C07D405/12 , C07D403/12 , C07D405/04 , C07D417/04 , C07D409/04 , C07D403/04 , C07D401/04 , A61K31/4196 , A61P35/00 , A61P5/00 , A61P25/00
CPC分类号： C07D401/04 , C07D249/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D417/04
摘要： The invention concerns novel 5-sulphanyl-4H-1,2,4-triazole derivatives of formula (I), wherein: R1, R2 and R3 represent variable groups and the methods for preparing them by liquid-phase parallel synthesis processes. Said product exhibit good affinity for certain sub-types of somatostatin receptors; they are particularly useful for treating pathological conditions or diseases wherein one (or more) somatostatin receptors is (are) involved. The invention also concerns pharmaceutical compositions containing said products and their use for preparing a medicine.
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公开(公告)号：EP1831209B1
公开(公告)日：2009-08-12
申请号：EP05826562.0
申请日：2005-12-16
申请人： IPSEN PHARMA
IPC分类号： C07D417/14 , C07D417/12 , C07D413/12 , A61K31/428 , A61P35/00 , A61P37/00 , A61P29/00
CPC分类号： C07D417/14 , C07D263/56 , C07D277/64
摘要： The invention relates to novel compounds comprising two or three benzothiazole-4,7-diones or benzooxazole-4,7-diones units which inhibit cdc25 phosphatases, in particular an cdc25-C phosphatase. Said compounds are usable, in particular for treating cancer.
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