公开(公告)号：EP1993555B1

公开(公告)日：2012-10-17

申请号：EP07731089.4

申请日：2007-03-06

申请人： IPSEN PHARMA

发明人： PIGNOL, Bernadette ,  AUVIN, Serge ,  BIGG, Dennis ,  CHABRIER DE LASSAUNIERE, Pierre-Etienne

IPC分类号： A61K31/5415 ,  A61K31/573 ,  A61K31/341 ,  A61K31/58 ,  A61K31/585 ,  A61P21/00

CPC分类号： A61K31/341 ,  A61K31/5415 ,  A61K31/573 ,  A61K31/58 ,  A61K31/585 ,  A61K2300/00

公开(公告)号：EP2024335B1

公开(公告)日：2010-06-23

申请号：EP07731364.1

申请日：2007-04-26

申请人： IPSEN PHARMA

发明人： LIBERATORE, Anne-Marie ,  BIGG, Dennis ,  PONS, Dominique ,  PREVOST, Grégoire

IPC分类号： C07D233/54 ,  A61K31/4164 ,  A61P29/00 ,  A61P35/00 ,  A61P19/00

CPC分类号： C07D233/64

摘要： The invention concerns novel imidazole derivatives of general formula (I), wherein Z' and Z represent different variable groups. Said products have an antitumoral activity. The invention also concerns pharmaceutical compositions containing said products and their use for preparing an antitumoral medicine.

公开(公告)号：EP1675836B1

公开(公告)日：2016-04-13

申请号：EP04791489.0

申请日：2004-10-08

申请人： IPSEN PHARMA

发明人： CHABRIER DE LASSAUNIERE, Pierre-Etienne ,  HARNETT, Jeremiah ,  BIGG, Dennis ,  LIBERATORE, Anne-Marie ,  THURIEAU, Christophe ,  DONG, Zheng, Xin

IPC分类号： C07D277/28 ,  A61K31/426 ,  A61P25/28 ,  A61P29/00 ,  A61P25/08

CPC分类号： C07D233/64 ,  A61K31/417 ,  A61K31/4178 ,  A61K31/42 ,  A61K31/421 ,  A61K31/426 ,  A61K31/427 ,  A61K31/454 ,  A61K31/496 ,  C07D233/50 ,  C07D261/04 ,  C07D263/32 ,  C07D277/24 ,  C07D277/28 ,  C07D277/34 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14

公开(公告)号：EP2419422A1

公开(公告)日：2012-02-22

申请号：EP10717194.4

申请日：2010-04-16

申请人： IPSEN PHARMA S.A.S.

发明人： BIGG, Dennis ,  AUVIN, Serge ,  LANCO, Christophe ,  PREVOST, Grégoire

IPC分类号： C07D403/06 ,  C07D403/12 ,  A61K31/4166 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07D403/06

摘要： The subject matter of the present application is novel imidazolidine-2,4-dione derivatives of general formula (I) in which R
1 , R
2 , R
3 and X are variables. These products have an anti-proliferative activity. They are particularly advantageous for treating pathological conditions and diseases associated with abnormal cell proliferation, such as cancers. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for preparing a medicament.

公开(公告)号：EP2152675A1

公开(公告)日：2010-02-17

申请号：EP08805532.2

申请日：2008-04-30

申请人： IPSEN PHARMA S.A.S.

发明人： PREVOST, Grégoire ,  LIBERATORE, Anne-Marie ,  BIGG, Dennis ,  PONS, Dominique

IPC分类号： C07D239/50 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D405/12 ,  C07D417/12 ,  C07D401/12 ,  C07D401/14 ,  C07D239/48

CPC分类号： C07D239/50 ,  C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to novel triaminopyrimidine derivatives of formula (I) in which R1, R2, W, R3, R4, and R5 are variable groups. These products have a Cdc25-phosphatase-inhibiting activity. The invention also relates to a process for synthesizing these compounds and also to therapeutic compositions containing these products and to the use thereof as medicaments.

公开(公告)号：EP1379514B1

公开(公告)日：2009-07-15

申请号：EP02761921.2

申请日：2002-04-09

申请人： IPSEN PHARMA

发明人： HARNETT, Jeremiah ,  BIGG, Dennis ,  LIBERATORE, Anne-Marie ,  ROLLAND, Alain

IPC分类号： C07D277/28 ,  A61K31/33 ,  A61P43/00 ,  C07D277/34 ,  C07D417/04 ,  C07D417/06 ,  C07D233/50 ,  C07D401/06 ,  C07D417/14 ,  C07D233/54

CPC分类号： C07D401/06 ,  C07D233/50 ,  C07D233/64 ,  C07D263/32 ,  C07D277/28 ,  C07D277/34 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14

摘要： The invention relates to thiazole, oxazole or imidazole derivatives having at least one of the following pharmacological activities: inhibition of monoamine oxidases (MAO); inhibition of lipid peroxidation; modulation of sodium channels. The inventive compounds comprise, for example, 2,6-ditert-butyl-4-{2-[2-(methylamino)ethyl]-1,3-thiazol-4-yl}phenol; et le 2-[4-(1,1'-biphenyl-4-yl)-1H-imidazol-2-yl]ethylcarbamate de 4-methylpenty l. By virtue of their pharmacological properties, said compounds can be used to treat one of the following disorders or diseases: Parkinson's disease, senile dementia, Alzheimer's disease, Huntington's chorea, amyotrophic lateral sclerosis, schizophrenia, depression, psychoses, migraine or pain, especially neuropathic pain.

公开(公告)号：EP2419422B1

公开(公告)日：2014-10-15

申请号：EP10717194.4

申请日：2010-04-16

申请人： IPSEN PHARMA S.A.S.

发明人： BIGG, Dennis ,  AUVIN, Serge ,  LANCO, Christophe ,  PREVOST, Grégoire

IPC分类号： C07D403/06 ,  C07D403/12 ,  A61K31/4166 ,  A61P35/00

CPC分类号： C07D403/12 ,  C07D403/06

公开(公告)号：EP1954288B1

公开(公告)日：2012-08-01

申请号：EP06820232.4

申请日：2006-10-18

申请人： IPSEN PHARMA

发明人： AUVIN, Serge ,  BIGG, Dennis ,  CHABRIER DE LASSAUNIERE, Pierre-Etienne ,  PIGNOL, Bernadette

IPC分类号： A61K31/5415 ,  C07D417/12 ,  C07D279/20

CPC分类号： C07D417/12 ,  C07D279/16 ,  C07D279/20

摘要： The invention concerns amidine derivatives of general formula (I) exhibiting an inhibitory activity of calpains and/or a trapping activity of reactive forms of oxygen.

公开(公告)号：EP2102162A1

公开(公告)日：2009-09-23

申请号：EP07866449.7

申请日：2007-10-26

申请人： IPSEN PHARMA S.A.S.

发明人： POITOUT, Lydie ,  HARNETT, Jeremiah ,  BIGG, Dennis ,  SACKUR, Carole ,  FERRANDIS, Eric

IPC分类号： C07D215/48 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D285/12 ,  C07D311/80 ,  C07D413/12 ,  C07C233/00 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/47 ,  A61P37/00

CPC分类号： C07D271/107 ,  C07D215/48 ,  C07D263/32 ,  C07D271/06 ,  C07D285/12 ,  C07D311/80 ,  C07D413/12

摘要： The present invention relates to new phenylic derivatives, wherein these products exhibit a good affinity for certain sub-types of cannabinoid receptors, in particular the CB2 receptors. They are of particular interest for treating pathological conditions and diseases in which one or more cannabinoid receptors are involved. The invention also relates to pharmaceutical compositions containing said products, and to the use thereof for the preparation of a drug.

公开(公告)号：EP1831209B1

公开(公告)日：2009-08-12

申请号：EP05826562.0

申请日：2005-12-16

申请人： IPSEN PHARMA

发明人： SIDHU, Alban ,  PREVOST, Grégoire ,  BIGG, Dennis ,  GALCERA CONTOUR, Marie-Odile

IPC分类号： C07D417/14 ,  C07D417/12 ,  C07D413/12 ,  A61K31/428 ,  A61P35/00 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D417/14 ,  C07D263/56 ,  C07D277/64

摘要： The invention relates to novel compounds comprising two or three benzothiazole-4,7-diones or benzooxazole-4,7-diones units which inhibit cdc25 phosphatases, in particular an cdc25-C phosphatase. Said compounds are usable, in particular for treating cancer.