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公开(公告)号：EP4233869A3
公开(公告)日：2023-11-01
申请号：EP23161858.8
申请日：2014-02-28
发明人： LI, Yun-Long , YAO, Wenqing , COMBS, Andrew P. , YUE, Eddy W. , MEI, Song , ZHU, Wenyu , GLENN, Joseph , MADUSKUIE, JR., Thomas P. , SPARKS, Richard B. , DOUTY, Brent , HE, Chunhong
IPC分类号： A61K31/519 , A61K31/5377 , A61P35/00 , C07D487/04
摘要： The present application provides methods of treating PI3Kδ related disorders using compounds of Formula I:
or pharmaceutically acceptable salts thereof.-
公开(公告)号：EP3513793A1
公开(公告)日：2019-07-24
申请号：EP18215449.2
申请日：2012-08-31
发明人： LI, Yun-Long , YAO, Wenqing , COMBS, Andrew, P. , YUE, Eddy, W. , MEI, Song , ZHU, Wenyu , GLENN, Joseph , MADUSKUIE, Thomas, P., Jr. , SPARKS, Richard, B. , DOUTY, Brent , HE, Chunhong
摘要： The present invention provides heterocyclylamine derivatives of Formula I:
wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.-
公开(公告)号：EP3888657A1
公开(公告)日：2021-10-06
申请号：EP21158471.9
申请日：2012-08-31
发明人： LI, Yun-Long , YAO, Wenqing , COMBS, Andrew, P. , YUE, Eddy, W. , MEI, Song , ZHU, Wenyu , GLENN, Joseph , MADUSKUIE, Thomas, P., Jr. , SPARKS, Richard, B. , DOUTY, Brent , HE, Chunhong
摘要： The present invention provides heterocyclylamine derivatives of Formula I:
wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.-
公开(公告)号：EP3632442A1
公开(公告)日：2020-04-08
申请号：EP19208523.1
申请日：2014-02-28
发明人： LI, Yun-Long , YAO, Wenqing , COMBS, Andrew P. , YUE, Eddy W. , MEI, Song , ZHU, Wenyu , GLENN, Joseph , MADUSKUIE, JR., Thomas P. , SPARKS, Richard B. , DOUTY, Brent , HE, Chunhong
IPC分类号： A61K31/519 , A61K31/5377 , A61P35/00
摘要： The present application provides methods of treating PI3Kδ related disorders using compounds of Formula I:
or pharmaceutically acceptable salts thereof.-
公开(公告)号：EP2961410B1
公开(公告)日：2019-12-11
申请号：EP14710739.5
申请日：2014-02-28
发明人： LI, Yun-Long , YAO, Wenqing , COMBS, Andrew P. , YUE, Eddy W. , MEI, Song , ZHU, Wenyu , GLENN, Joseph , MADUSKUIE, JR., Thomas P. , SPARKS, Richard B. , DOUTY, Brent , HE, Chunhong
IPC分类号： A61K31/519 , A61K31/5377 , A61P35/00
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公开(公告)号：EP3196202B1
公开(公告)日：2019-02-27
申请号：EP16199883.6
申请日：2012-08-31
发明人： LI,, Yun-Long , YAO,, Wenqing , COMBS,, Andrew, P. , YUE,, Eddy, W. , MEI,, Song , ZHU, Wenyu , GLENN,, Joseph , MADUSKUIE,, Thomas, P., Jr. , SPARKS,, Richard, B. , DOUTY,, Brent , HE,, Chunhong
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00 , A61P27/00 , A61P19/00 , A61P1/00 , A61P17/00
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公开(公告)号：EP4233869A2
公开(公告)日：2023-08-30
申请号：EP23161858.8
申请日：2014-02-28
发明人： LI, Yun-Long , YAO, Wenqing , COMBS, Andrew P. , YUE, Eddy W. , MEI, Song , ZHU, Wenyu , GLENN, Joseph , MADUSKUIE, JR., Thomas P. , SPARKS, Richard B. , DOUTY, Brent , HE, Chunhong
IPC分类号： A61K31/519 , A61K31/5377 , A61P35/00
摘要： The present application provides methods of treating PI3Kδ related disorders using compounds of Formula I:
or pharmaceutically acceptable salts thereof.-
公开(公告)号：EP3360873A1
公开(公告)日：2018-08-15
申请号：EP17211181.7
申请日：2009-07-07
发明人： COMBS, Andrew, P. , YUE, Eddy, W. , SPARKS, Richard, B. , ZHU, Wenyu , ZHOU, Jiacheng , LIN, Qiyan , WENG, Lingkai , YUE, Tai-Yuen , LIU, Pingli
IPC分类号： C07D413/04 , C07D413/12 , C07D271/08 , A61K31/4245 , A61K39/00 , A61K39/395
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
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公开(公告)号：EP3196202A1
公开(公告)日：2017-07-26
申请号：EP16199883.6
申请日：2012-08-31
发明人： LI,, Yun-Long , YAO,, Wenqing , COMBS,, Andrew, P. , YUE,, Eddy, W. , MEI,, Song , ZHU, Wenyu , GLENN,, Joseph , MADUSKUIE,, Thomas, P., Jr. , SPARKS,, Richard, B. , DOUTY,, Brent , HE,, Chunhong
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00 , A61P27/00 , A61P19/00 , A61P1/00 , A61P17/00
CPC分类号： A61K31/519 , C07D471/04 , C07D487/04 , C07D519/00
摘要： The present invention provides heterocyclylamine derivatives of Formula I:
wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.摘要翻译： 本发明提供式I的杂环胺衍生物：其中变量在本文中定义，其调节磷酸肌醇3-激酶（PI3K）的活性并且可用于治疗与PI3K活性有关的疾病，包括例如炎症性疾病 ，基于免疫的疾病，癌症和其他疾病。
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公开(公告)号：EP2751109B1
公开(公告)日：2016-11-30
申请号：EP12775861.3
申请日：2012-08-31
发明人： LI, Yun-Long , YAO, Wenqing , COMBS, Andrew, P. , YUE, Eddy, W. , MEI, Song , ZHU, Wenyu , GLENN, Joseph , MADUSKUIE, Thomas, P., Jr. , SPARKS, Richard, B. , DOUTY, Brent , HE, Chunhong
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00 , A61P27/00 , A61P19/00 , A61P1/00 , A61P17/00 , C07D519/00
CPC分类号： A61K31/519 , C07D471/04 , C07D487/04 , C07D519/00
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