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    METHOD FOR MEASURING GLYCATED HEMOGLOBIN
    1.
    发明公开
    METHOD FOR MEASURING GLYCATED HEMOGLOBIN 审中-公开
    VERFAHREN ZUR MESSUNG VON GLYKIERTEMHÄMOGLOBIN

    公开(公告)号：EP2444803A1

    公开(公告)日：2012-04-25

    申请号：EP09846223.7

    申请日：2009-06-19

    申请人： Infopia Co., Ltd.

    发明人： BAE, Byeong-Woo ,  LEE, Sung-Dong ,  KIM, Hyong-Soo

    IPC分类号： G01N33/49 ,  G01N33/52

    CPC分类号： G01N33/723

    摘要： The present invention relates to a method for measuring glycated hemoglobin. The method of the present invention comprises: a hemolysis step of hemolyzing a blood sample with a hemolysate; a reaction step of reacting the hemolyzed blood sample with bead conjugates in which beads are conjugated with glycated hemoglobin binding materials; a first measuring step of measuring the amount of total hemoglobin in blood; an isolation step of isolating normal hemoglobin from the glycated hemoglobin conjugated with the bead conjugates; a second measuring step of measuring the amount of glycated hemoglobin in blood; and a calculation step of calculating the concentration of glycated hemoglobin in the blood sample based on the measured amounts of total hemoglobin and glycated hemoglobin in the blood sample. The method for measuring the glycated hemoglobin of the present invention is able to simplify measuring steps by measuring the total amount of hemoglobin in blood from a blood sample that contains normal hemoglobin and glycated hemoglobin conjugated with bead conjugates in which beads and glycated hemoglobin are conjugated. In addition, the present invention enables easier measurement of the concentration of glycated hemoglobin in the blood sample since a separate dye for signal amplification is not needed.

    摘要翻译： 本发明涉及测定糖化血红蛋白的方法。 本发明的方法包括：用溶血液使血液样品溶血的溶血步骤; 使溶血的血液样品与其中珠粒与糖化血红蛋白结合材料缀合的珠缀合物的反应步骤; 测量血液中总血红蛋白量的第一测量步骤; 从与珠缀合物缀合的糖化血红蛋白分离正常血红蛋白的分离步骤; 测量血液中糖化血红蛋白量的第二测量步骤; 以及计算步骤，根据测定的血液样品中的总血红蛋白和糖化血红蛋白量，算出血液样品中糖化血红蛋白的浓度。 本发明的糖化血红蛋白的测定方法能够简化测定步骤，通过测定血液中血红蛋白的总量，该血液中血红蛋白含有正常血红蛋白和与珠粒和糖基化血红蛋白共轭的珠子缀合物的糖化血红蛋白。 此外，本发明能够更容易地测量血液样品中糖化血红蛋白的浓度，因为不需要单独的信号放大染料。

    METHOD FOR AMPLIFICATION OF SIGNAL IN IMMUNOCHROMATOGRAPHIC ASSAY AND IMMUNOCHROMATOGRAPHIC KIT USING THE METHOD
    4.
    发明公开
    METHOD FOR AMPLIFICATION OF SIGNAL IN IMMUNOCHROMATOGRAPHIC ASSAY AND IMMUNOCHROMATOGRAPHIC KIT USING THE METHOD 有权
    一种用于在IMMUNCHROMATOGRAPHIETEST和免疫KIT信号增益，利用该程序

    公开(公告)号：EP2376906A1

    公开(公告)日：2011-10-19

    申请号：EP08878455.8

    申请日：2008-11-28

    申请人： Infopia Co., Ltd.

    发明人： BAE, Byeong-Woo ,  LEE, Sung-Dong ,  KIM, Min-Gon ,  SHIN, Yong-Beom ,  JANG, Jin-Hee ,  SHIN, Ji-Hun

    IPC分类号： G01N30/90 ,  G01N33/53 ,  G01N33/48 ,  G01N33/487

    CPC分类号： G01N33/558 ,  G01N33/585

    摘要： The present invention relates to a method for amplifying a signal in an immunochro- matographic assay for high- sensitivity detection of an analyte and an immunochromatographic kit using the method, which amplifies a signal by controlling a flow rate by discrimination between the size of a first indicator and the size of a second indicator. According to an aspect of the present invention, a method for amplifying a signal in an im¬ munochromatographic assay includes: binding a primary conjugate body, which has a first antibody binding specifically to a first epitope of an analyte, a connector, and a first indicator to which the first antibody and the connector are bound, to the analyte; binding the analyte bound to the primary conjugate body to an immobilized second antibody binding specifically to a second epitope of the analyte; and binding a secondary conjugate body, which has a third antibody binding specifically to the connector of the primary conjugate body and a second indicator to which the third antibody is bound, to the connector of the primary conjugate body, wherein the primary conjugate body is disposed nearer to the immobilized second antibody than the secondary conjugate body, and the particle of the second indicator is larger than the particle of the first indicator, so that the secondary conjugate body reaches the immobilized second antibody later than the primary conjugate body. According to another aspect of the present invention, an immunochromatographic kit includes: a sample pad to which a liquid sample containing an analyte is applied; a conjugate pad including a primary conjugate body having a first antibody binding specifically to a first epitope of an analyte, a connector, and a first indicator to which the first antibody and the connector are bound, and a secondary conjugate body having a third antibody binding specifically to the connector of the primary conjugate body and a second indicator to which the third antibody is bound, wherein the primary conjugate body is disposed nearer to an immobilized second antibody than the secondary conjugate body and the second indicator is larger than the first indicator so that the secondary conjugate body reaches the immobilized second antibody later than the primary conjugate body; a membrane including a detection site immobilizing thereto the second antibody binding specifically to a second epitope of the analyte to which the primary conjugate body is bound, and a control site for error detection; and an absorbing pad absorbing the liquid sample by a capillary phenomenon. Thus, the present invention can perform signal amplification without separate mechanical control or artificial step-by-step reaction.

    BIOSENSOR
    6.
    发明公开
    BIOSENSOR 有权
    生物传感器

    公开(公告)号：EP2439532A2

    公开(公告)日：2012-04-11

    申请号：EP10783512.6

    申请日：2010-04-07

    申请人： Infopia Co., Ltd.

    发明人： BAE, Byeong-Woo ,  LEE, Sung-Dong ,  KHO, Byung-Hoon ,  RYU, Ji-Eon ,  KIM, Jin-Kyeong ,  JOUNG, Hyou-Arm ,  AHN, Ku-Cheol

    IPC分类号： G01N33/52 ,  G01N21/77

    CPC分类号： C12Q1/006

    摘要： Disclosed herein is a biosensor. The biosensor includes a measuring layer configured to measure whether reaction to a biological sample has occurred.
    A lower cover is disposed below the measuring layer, and is provided with a lower protrusion which protrudes between an open window configured to allow a measurement area of the measuring layer to be exposed and an upper protrusion of an upper cover so that the lower protrusion is spaced apart from the upper protrusion by a predetermined gap and which presses the measuring layer so that a top of the measuring layer upwardly protrudes from the open window. The upper cover is disposed on a top of the measuring layer, and is provided with the open window and the upper protrusion configured to protrude from an outer portion of the open window in a direction in which the upper protrusion is coupled to the lower cover. Accordingly, the biosensor can minimize the difference in the amount of blood serum reaching a final reaction layer while minimizing the amount of biological sample required for measurement.

    摘要翻译： 本文公开了一种生物传感器。 生物传感器包括测量层，其被配置为测量是否已经发生对生物样品的反应。 下盖设置在测量层下方，并且设置有下突起，该下突起在构造成允许测量层的测量区域被暴露的打开窗口和上盖的上突起之间突出，使得下突起是 与上突出部间隔开预定的间隙，并且按压测量层，使得测量层的顶部从打开的窗口向上突出。 所述上盖设置在所述测量层的顶部，并且设置有所述开放窗口，所述上部突起构造成在所述上部突起联接到所述下部盖的方向上从所述开放窗口的外部部分突出。 因此，生物传感器可以将达到最终反应层的血清量的差异最小化，同时最小化测量所需的生物样品的量。

    STRIP FOR MEASURING BIODATA AND METHOD FOR MEASURING BIODATA
    7.
    发明公开
    STRIP FOR MEASURING BIODATA AND METHOD FOR MEASURING BIODATA 有权
    VERFAHREN ZUR MESSUNG VON BIODATEN STREIFEN ZUR MESSUNG VON BIODATEN

    公开(公告)号：EP2438859A2

    公开(公告)日：2012-04-11

    申请号：EP10783520.9

    申请日：2010-04-26

    申请人： Infopia Co., Ltd

    发明人： BAE, Byeong-Woo ,  LEE, Sung-Dong ,  KHO, Byung-Hoon ,  RYU, Ji-Eon ,  KIM, Jin-Kyeong ,  JOUNG, Hyou-Arm

    IPC分类号： A61B5/145

    CPC分类号： G01N33/525 ,  C12Q1/60 ,  G01N33/92

    摘要： Disclosed is a test strip for measuring biomedical data, in which a hydrophilic material is introduced to improve the spreadability of blood. Having the structure comprising a blood-filtering layer designed to filter off either or both of erythrocytes and low-density lipoprotein (LDL) cholesterol from an applied blood sample; a reaction layer in which the blood sample free of erythrocytes and/or low-density lipoprotein (LDL) cholesterol is reacted with an reagent, and a hydrophilic layer, intercalated between the blood-filtering layer and the reaction layer, for uniformly spreading the blood sample filtered through the filtering layer, the blood-filtering layer and the reaction layer being stacked between the lower support and the upper cover, the test strip prevents the infiltration of erythrocytes into the reaction layer and improves the spreadability of blood to reduce measurement errors, thus bringing about higher reproducibility.

    摘要翻译： 公开了一种用于测量生物医学数据的测试条，其中引入亲水材料以改善血液的铺展性。 具有包括血液过滤层的结构，其设计成从施用的血液样品中过滤掉红细胞和低密度脂蛋白（LDL）胆固醇中的任一者或两者; 使没有红细胞和/或低密度脂蛋白（LDL）胆固醇的血液样品与试剂反应的反应层和插入血液过滤层和反应层之间的亲水层，以均匀地分散血液 样品通过过滤层过滤，血液过滤层和反应层堆叠在下支撑体和上盖之间，试纸条防止红细胞浸入反应层，提高血液的铺展性，减少测量误差， 从而带来更高的再现性。

    CHOLESTEROL-MEASURING STRIP AND METHOD FOR MEASURING CHOLESTEROL USING SAME
    8.
    发明公开
    CHOLESTEROL-MEASURING STRIP AND METHOD FOR MEASURING CHOLESTEROL USING SAME 有权
    HDL-CHOLESTERINMESSSTREIFEN UND VERFAHREN ZUR CHOLESTERINMESSUNG DAMIT

    公开(公告)号：EP2438856A2

    公开(公告)日：2012-04-11

    申请号：EP10783511.8

    申请日：2010-04-02

    申请人： Infopia Co., Ltd.

    发明人： BAE, Byeong-Woo ,  LEE, Sung-Dong ,  KHO, Byung-Hoon ,  RYU, Ji-Eon ,  KIM, Jin-Kyeong ,  JOUNG, Hyou-Arm

    IPC分类号： A61B5/145

    CPC分类号： G01N33/526 ,  C12Q1/60 ,  G01N33/92

    摘要： Disclosed are a test strip and a method for measuring biomedical data. The test strip comprises an upper cover having one or more application holes; a lower support having one or more detected parts at positions corresponding to detecting units of the measuring apparatus; an erythrocyte and LDL cholesterol-filtering layer designed to filter off both of erythrocytes and LDL cholesterol from an applied blood sample by agglutinating erythrocytes and precipitating LDL cholesterol; and a reaction layer in which the blood sample free of erythrocytes and LDL cholesterol is reacted with an reagent, the filtering layer and the reaction layer being stacked between the lower support and the upper cover. Structured to filter off erythrocytes and low-density lipoprotein (LDL) cholesterol from a blood sample in a single layer, the test strip of the present invention can be made to be slim and allows a low volume of blood to be analyzed.

    摘要翻译： 公开了一种测试条和用于测量生物医学数据的方法。 测试条包括具有一个或多个施加孔的上盖; 具有在与所述测量装置的检测单元对应的位置处具有一个或多个检测到的部件的下支撑件; 红细胞和低密度脂蛋白胆固醇过滤层设计用于通过凝集红细胞和沉淀LDL胆固醇从应用的血液样品中滤出红细胞和低密度脂蛋白胆固醇; 将没有红细胞和LDL胆固醇的血液样品与试剂反应的反应层，过滤层和反应层堆叠在下支撑体和上盖之间。 结构化以从单层血液样品中过滤掉红细胞和低密度脂蛋白（LDL）胆固醇，本发明的测试条可以使其纤细，并允许分析低体积的血液。