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公开(公告)号：EP3177597B1
公开(公告)日：2020-03-11
申请号：EP15748009.6
申请日：2015-07-31
发明人： KIM, Jaeseung , AHN, Seohyun , JEON, Yeejin , PARK, Dongsik , YANG, Young-In , LEE, Doohyung , LEE, SaeYeon , AHN, Jiye , KIM, Jeongjun , NAM, Kiyean , KANG, Sunhee , SEO, MinJung , SEO, Mooyoung , SEO, Jeongjea , HAN, Sung-Jun , KIM, Jung Hwan , LEE, Sangchul , CHOI, Gahee , LEE, Yunmi
IPC分类号： C07D235/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/4184
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2.发明公开2-AMINO-BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE AND/OR PROSTAGLANDIN E SYNTHASE INHIBITORS 审中-公开2-氨基 - 苯并咪唑衍生物及其作为5-脂氧合酶和/或前列腺素E合成酶抑制剂的用途
公开(公告)号：EP3177597A1
公开(公告)日：2017-06-14
申请号：EP15748009.6
申请日：2015-07-31
发明人： KIM, Jaeseung , AHN, Seohyun , JEON, Yeejin , PARK, Dongsik , YANG, Young-In , LEE, Doohyung , LEE, SaeYeon , AHN, Jiye , KIM, Jeongjun , NAM, Kiyean , KANG, Sunhee , SEO, MinJung , SEO, Mooyoung , SEO, Jeongjea , HAN, Sung-Jun , KIM, Jung Hwan , LEE, Sangchul , CHOI, Gahee , LEE, Yunmi
IPC分类号： C07D235/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/4184
摘要： The present invention relates to benzimidazole derivatives having the general formula I, wherein n is 0 or 1; X1 and X2 are independently, at each occurrence, CR5 or N; Y is C1-C6 alkylene, wherein alkylene is optionally substituted with one to two C1-C3 alkyl groups; R1 is selected from the group consisting of hydrogen, halogen, C1-C6 alkoxy, -NH2, -NHR6, -NR7R8 and -NH-(R9)n-R10, n being 0 or 1; R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, -NH2, -NHR6, - NR7R8 and -NH-(R9)n-R10; R3 is selected from the group consisting of hydrogen, hydroxyl, OR11, -NR7R8, C1-C6 alkoxy, C1-C6 alkyl, C3-C10 cycloalkyl, C1-C3 haloalkyl, -C(O)NHR11, aryl, heteroaryl and heterocyclyl, wherein each of said cycloalkyl, aryl, heteroaryl and heterocyclyl is optionally and independently substituted with one to four Ra groups; and R4 is selected from the group consisting of -NH2, -N(R12)(V)pR13, - NH(V)p-OR14, -NHC(O)R15, and groups of formula la shown below, and their use in the treatment of diseases, in particular inflammatory diseases, cancer, stroke and/or Alzheimer's disease.
摘要翻译： 本发明涉及具有通式I的苯并咪唑衍生物，其中n是0或1; X1和X2在每次出现时独立地为CR5或N; Y是C 1 -C 6亚烷基，其中亚烷基任选被一个至两个C 1 -C 3烷基取代; R1选自氢，卤素，C1-C6烷氧基，-NH2，-NHR6，-NR7R8和-NH-（R9）n-R10，n为0或1; R2选自氢，卤素，C1-C6烷基，-NH2，-NHR6，-NR7R8和-NH-（R9）n-R10; R3选自氢，羟基，OR11，-NR7R8，C1-C6烷氧基，C1-C6烷基，C3-C10环烷基，C1-C3卤代烷基，-C（O）NHR11，芳基，杂芳基和杂环基， 其中所述环烷基，芳基，杂芳基和杂环基中的每一个任选且独立地被1至4个Ra基团取代; 并且R4选自-NH2，-N（R12）（V）pR13，-NH（V）p-OR14，-NHC（O）R15和下面所示的式Ia的基团，以及它们在 治疗疾病，特别是炎性疾病，癌症，中风和/或阿尔茨海默氏病。
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公开(公告)号：EP3027615A2
公开(公告)日：2016-06-08
申请号：EP14745158.7
申请日：2014-08-01
发明人： KIM, Jaeseung , KANG, Sunhee , SEO, Min Jung , SEO, Mooyoung , SEO, Jeongjea , LEE, Sumi , KANG, Juhee , PARK, Dongsik , KIM, Ryang Yeo , PETHE, Kevin , NAM, Kiyean , KIM, Jeongjun , OH, Soohyun , LEE, Saeyeon , AHN, Jiye
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.
摘要翻译： 本发明涉及小分子化合物及其在治疗细菌感染，特别是结核病中的用途。
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公开(公告)号：EP3774776A1
公开(公告)日：2021-02-17
申请号：EP19728645.3
申请日：2019-05-31
申请人： Qurient Co. Ltd.
发明人： NAM, Kiyean , KIM, Jaeseung , PARK, Dongsik , JEON, Yeejin , YANG, Yeong-In , KANG, Hwan Kyu
IPC分类号： C07D401/14 , C07D401/12 , A61P35/00 , A61K31/4709
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公开(公告)号：EP4255909A1
公开(公告)日：2023-10-11
申请号：EP21819125.2
申请日：2021-11-29
申请人： Qurient Co. Ltd.
发明人： NAM, Kiyean , KIM, Jaeseung , PARK, Dongsik , SEO, Mooyoung , JEON, Yeejin , YU, Donghoon
IPC分类号： C07D487/04 , C07F9/24 , A61K31/53 , A61K31/6615 , A61P9/00 , A61P31/00 , A61P35/00 , A61P37/00
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公开(公告)号：EP4003521A1
公开(公告)日：2022-06-01
申请号：EP19756324.0
申请日：2019-07-30
申请人： Qurient Co. Ltd.
发明人： NAM, Kiyean , KIM, Jaeseung , JUNG, Chunwon , LEE, Saeyeon
IPC分类号： A61P31/04 , A61P31/06 , C07D471/04 , A61K31/437
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公开(公告)号：EP4431114A3
公开(公告)日：2024-11-13
申请号：EP24176555.1
申请日：2020-12-17
申请人： Qurient Co. Ltd.
发明人： NAM, Kiyean , KIM, Jaeseung , JUNG, Chunwon , LEE, Saeyeon
IPC分类号： A61K31/437 , A61K9/28 , A61K47/38 , A61K47/32 , A61K47/26 , A61K9/20 , A61P31/04 , A61P31/06
摘要： The present invention relates to new pharmaceutical dosage forms of 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide, in particular of its ditosylate form.
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公开(公告)号：EP3774809A1
公开(公告)日：2021-02-17
申请号：EP19720424.1
申请日：2019-04-11
发明人： NAM, Kiyean , KIM, Jaeseung , JEON, Yeejin , YU, Donghoon , SEO, Mooyoung , PARK, Dongsik , EICKHOFF, Jan , ZISCHINSKY, Gunther , KOCH, Uwe
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公开(公告)号：EP3286177B1
公开(公告)日：2020-05-06
申请号：EP16716247.8
申请日：2016-04-14
发明人： NAM, Kiyean , KIM, Jaeseung , AHN, Seohyun , JEON, Yeejin , LEE, Doohyung , PARK, Dongsik , YANG, Yeong-In , LEE, SaeYeon , KIM, Jeongjun , AHN, Jiye , KIM, Hana , JUNG, Chun-won , SCHULTZ-FADEMRECHT, Carsten
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , C07D409/14 , C07D417/14 , A61K31/4709 , A61P35/00
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公开(公告)号：EP4431114A2
公开(公告)日：2024-09-18
申请号：EP24176555.1
申请日：2020-12-17
申请人： Qurient Co. Ltd.
发明人： NAM, Kiyean , KIM, Jaeseung , JUNG, Chunwon , LEE, Saeyeon
IPC分类号： A61K47/26
CPC分类号： A61K31/437 , A61K9/2866 , A61K47/38 , A61K47/32 , A61K47/26
摘要： The present invention relates to new pharmaceutical dosage forms of 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidine-1-yl)benzyl)imidazo[1,2-a]pyridine-3-carboxamide, in particular of its ditosylate form.
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