摘要:
A novel and practically excellent process for preparing optically active compounds, such as optically active alcohols or amines, useful for various applications of, for example, synthetic intermediates of pharmaceuticals, liquid crystalline materials, and reagents for optical resolution, wherein a hydrogen transfer type asymmetric reduction is carried out in the presence of both a transition metal complex and an optically active nitrogen compound or a transition metal complex having an optically active nitrogen compound as an asymmetric ligand, and a hydrogen-donating organic or inorganic compound. Further, optically active secondary alcohols are prepared from racemic secondary alcohols or meso-diols by a hydrogen transfer oxidation.
摘要:
The present invention pertains to a method of producing, in a few simple steps, a specified optically-active aldehyde represented by general formula (1) through the asymmetric isomerization of a specified allyl alcohol represented by general formula (2) in the presence of a ruthenium complex and a base.
摘要:
Ligands characterized by being represented by the general formula (1): R R N-Q -X-Q -NR R wherein R , R , R and R are each independently a group represented by the general formula (2): (2) (wherein Q is optionally substituted alkylene, optionally substituted cycloalkylene, optionally substituted arylene, or an optionally substituted divalent heterocyclic group; R is optionally substituted alkyl, optionally substituted aryl, or an optionally substituted heterocyclic group; and R is a substituent capable of coordinating or bonding to a metal atom, or R and R may be united to form a ring); Q and Q may be the same or different from each other and each represent optionally substituted alkylene or a single bond; and X is a divalent spacer.