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1.发明公开NUCLEIC ACID CONSTRUCT CONTAINING NUCLEIC ACID DERIVED FROM GENOTYPE 1B HCV GENOME, HCV GENOME-REPLICATING CELLS TRANSFECTED WITH SAME, AND METHOD FOR PRODUCING INFECTIOUS HCV PARTICLES 审中-公开WITH NUCLEIC CONSTRUCT从-1B-HCV基因组来源的核酸转染的SO HCV基因组复制型细胞AND METHOD FOR PRODUCING感染性HCV颗粒基因型
公开(公告)号：EP2692861A4
公开(公告)日：2014-12-17
申请号：EP12765083
申请日：2012-03-30
发明人： WAKITA TAKAJI , DATE TOMOKO , TANAKA YASUHITO , MIZOKAMI MASASHI
IPC分类号： C12N15/09 , A61K39/29 , A61P31/14 , C07K14/005 , C07K16/10 , C12N5/10 , C12N7/00 , C12N7/02 , C12N15/86 , C12Q1/68 , C12Q1/70 , G01N33/569
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , C07K14/005 , C07K16/082 , C07K16/109 , C12N15/86 , C12N2770/24221 , C12N2770/24222 , C12N2770/24231 , C12N2770/24234 , C12N2770/24243 , C12N2770/24251 , C12Q1/707 , C12Q2600/136 , C12Q2600/156
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2.发明公开NOVEL RECOMBINANT HUMAN HEPATITIS C VIRUS-LIKE PARTICLE AND METHOD FOR PRODUCING THE SAME 有权与函电人类丙型肝炎病毒和方法及其制造新型重组粒子
公开(公告)号：EP1930416A4
公开(公告)日：2009-03-11
申请号：EP06810937
申请日：2006-09-29
发明人： TANABE JUN-ICHI , SONE SABURO , WAKITA TAKAJI , ISHII KOJI , SUZUKI RYOSUKE , SUZUKI TETSURO , MIYAMURA TATSUO
CPC分类号： C12N7/00 , C12N15/86 , C12N2770/24223 , C12N2770/24243 , C12N2770/24252
摘要： The invention relates to a method for producing a recombinant hepatitis C virus-like particle comprising introducing into (i) a cell which autonomously replicates an RNA replicon including a base sequence encoding a 5’ noncoding region, NS3 protein, NS4A protein, NS4B protein, NS5A protein and NS5B protein in the genomic RNA derived from a hepatitis C virus strain and a base sequence including a 3’ noncoding region, (ii) a vector expressing Core protein, E1 protein, E2 protein and p7 protein derived from the same or a different hepatitis C virus strain in (i), culturing the cell and collecting the produced virus-like particle and a recombinant hepatitis C virus particle produced by the method.
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3.发明公开HCV VARIANT WITH HIGH PRODUCTIVITY OF INFECTIOUS HEPATITIS C VIRUS, AND USE THEREOF 审中-公开高生产率传染性丙型肝炎病毒及其用途HCV VERSION
公开(公告)号：EP2551345A4
公开(公告)日：2014-01-29
申请号：EP11759547
申请日：2011-03-25
申请人： UNIV TOKYO , UNIV NIHON , CHINESE ACAD INST MICROBIOLOGY , TORAY INDUSTRIES , JP NAT INST INFECTIOUS DISEASE , TOKYO METROPOLITAN INST MEDICAL SCIENCE
发明人： KITAMURA YOSHIHIRO , SHIMIZU YOKO , AOKI CHIE , YU LIJUAN , WAKITA TAKAJI
CPC分类号： C12N7/00 , A61K39/29 , C07K14/005 , C07K14/1833 , C12N2770/24221 , C12N2770/24222 , C12N2770/24243 , C12N2770/24251
摘要： An objective of this invention is to provide an HCV strain with a high capacity for virus production in a cell culture system. This invention provides a nucleic acid encoding a polyprotein precursor of the hepatitis C virus JFH1 strain having one or more amino acid substitutions, wherein the polyprotein precursor comprises at least substitution of glutamine at position 862 with arginine, as determined with reference to the amino acid sequence as shown in SEQ ID NO: 2 in the Sequence Listing.
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4.发明公开ANTIBODY HAVING INHIBITORY ACTIVITY ON INFECTION WITH HEPATITIS C VIRUS (HCV), AND USE THEREOF 审中-公开具有锁定效应对感染丙型肝炎病毒（HCV）和它的用途抗体
公开(公告)号：EP2177535A4
公开(公告)日：2010-08-25
申请号：EP08791668
申请日：2008-07-25
发明人： WAKITA TAKAJI , SUZUKI TETSURO , MORIKAWA KENICHI , OMI NORIAKI , NAKAMURA NORIKO , AKAZAWA DAISUKE
IPC分类号： C07K16/10 , A61K39/395 , A61P31/14 , C12N15/09 , C12P21/08 , G01N33/53 , G01N33/576
CPC分类号： C07K16/109 , C07K14/005 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C12N2770/24222 , G01N2333/186
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5.发明公开MUTANT REPLICON DERIVED FROM GENOME OF HEPATITIS C VIRUS J6CF STRAIN 审中-公开MUTANTES复制子FROM丙型肝炎病毒株的基因组J6CF
公开(公告)号：EP2716757A4
公开(公告)日：2015-02-25
申请号：EP12792554
申请日：2012-05-31
发明人： WAKITA TAKAJI , MURAYAMA ASAKO , KATO TAKANOBU
IPC分类号： C12N15/09 , A61K39/29 , A61P31/14 , C07K14/005 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12Q1/02
CPC分类号： A61K35/76 , A61K39/12 , C07K14/005 , C12N7/00 , C12N2770/24222 , C12N2770/24234 , G01N2333/186 , G01N2500/00
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公开(公告)号：EP2186893A4
公开(公告)日：2010-10-20
申请号：EP08778269
申请日：2008-07-11
发明人： WAKITA TAKAJI , SUZUKI TETSURO , TAKAHASHI HITOSHI
CPC分类号： A61K39/29 , A61K39/12 , C07K14/005 , C07K2319/43 , C12N7/00 , C12N2770/24222 , C12N2770/24234 , C12N2770/24251
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公开(公告)号：EP1956087A4
公开(公告)日：2009-05-27
申请号：EP06810936
申请日：2006-09-29
发明人： TANABE JUN-ICHI , SONE SABURO , WAKITA TAKAJI , ISHII KOJI , SUZUKI RYOSUKE , SUZUKI TETSURO , MIYAMURA TATSUO
CPC分类号： C12N7/00 , C12N15/86 , C12N2770/24243 , C12N2770/24252
摘要： The invention relates to a method for producing an infectious hepatitis C virus (HCV) particle, comprising the step of introducing an expression vector containing a DNA fragment including a DNA sequence encoding a 5’ noncoding region and a structural protein of HCV and an arbitrary nonstructural protein and a DNA sequence encoding a nonstructural protein and a 3’ noncoding region derived from HCV JFH1 strain downstream of the RNA polymerase I promoter and further containing a DNA fragment including the RNA polymerase I terminator downstream thereof into a cell which allows HCV proliferation.
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8.发明公开NUCLEIC ACID DERIVED FROM HEPATITIS C VIRUS, AND EXPRESSION VECTOR, TRANSFORMED CELL AND HEPATITIS C VIRUS PARTICLES EACH PREPARED BY USING SAME 审中-公开丙型肝炎病毒始发核酸并且每个用其生产/生产的表达载体，转化细胞和丙型肝炎病毒颗粒
公开(公告)号：EP2385116A4
公开(公告)日：2013-09-18
申请号：EP09835045
申请日：2009-12-25
申请人： TORAY INDUSTRIES , JP NAT INST OF INFECTIOUS DISEASES , TOKYO METROPOLITAN INST MEDICAL SCIENCE
发明人： WAKITA TAKAJI , DATE TOMOKO , TAKAHASHI HITOSHI
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N2770/24221 , C12N2770/24222 , C12N2770/24251
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9.发明公开NUCLEIC ACID CONSTRUCT INCLUDING NUCLEIC ACID DERIVED FROM GENOTYPE 3a HCV GENOME 审中-公开WITH获得的核酸基因型3A-HCV的基因组的核酸构建
公开(公告)号：EP2752485A4
公开(公告)日：2015-06-24
申请号：EP12827627
申请日：2012-08-31
申请人： JAPAN AS REPRESENTED BY THE DIRECTOR GENERAL OF NAT INST OF INFECTIOUS DISEASES , INSERM INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE , TORAY INDUSTRIES
CPC分类号： C07K14/005 , C07K16/109 , C12N7/00 , C12N2770/24221 , C12N2770/24222 , C12N2770/24234 , C12Q1/18 , G01N33/5008 , G01N33/5767 , G01N2333/186
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10.发明公开MODIFIED HUMAN HEPATITIS C VIRUS GENOMIC RNA HAVING AUTONOMOUS REPLICATIVE COMPETENCE 有权丙型肝炎病毒的经修饰的人基因组RNA的自主复制COMPETENCE
公开(公告)号：EP1801209A4
公开(公告)日：2007-12-05
申请号：EP05781421
申请日：2005-08-24
发明人： WAKITA TAKAJI , KATO TAKANOBU , DATE TOMOKO , MIYAMOTO MICHIKO , BARTENSCHLAGER RALF , TANABE JUN-ICHI , SONE SABURO
IPC分类号： C12N15/09 , A61K39/29 , A61K48/00 , A61P1/16 , A61P31/14 , C12N5/10 , C12N7/00 , C12Q1/68 , C12Q1/70
CPC分类号： C12N7/00 , A61K48/00 , A61K2039/525 , C12N15/86 , C12N2770/24221 , C12N2770/24243 , C12N2840/203 , C12Q1/6883
摘要： It is intended to provide a modified hepatitis C virus genomic RNA having a base sequence containing the 5’-nontranslated region, core protein-encoding sequence, E1 protein-encoding sequence, p7 protein-encoding sequence, E2 protein-encoding sequence, NS2 protein-encoding sequence, NS3 protein-encoding sequence, NS4A protein-encoding sequence, NS4B protein-encoding sequence, NS5A protein-encoding sequence, NS5B protein-encoding sequence and 3’-nontransalated region of two or more hepatitis C virus genomic RNAs and having autonomous replicative competence. In particular, a modified hepatitis C virus genomic RNA which has acquired the autonomous replicative competence via the substitution of a partial RNA sequence encoding NS3 to NS4, NS5A and NS5B proteins in a hepatitis C virus genomic RNA by the partial RNA sequence encoding NS3 to NS4, NS5A and NS5B proteins of JFH1 strain represented by SEQ ID NO:1.
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