公开(公告)号：EP1548016B1

公开(公告)日：2015-05-20

申请号：EP03794076.4

申请日：2003-08-06

申请人： Japan Science and Technology Agency ,  National University Corporation Kagoshima University

发明人： SUDA, Yasuo ,  ARANO, Akio ,  HAYASHI, Hideki ,  KUSUMOTO, Shoichi ,  SOBEL, Michael

IPC分类号： C07D495/04 ,  C07H15/203 ,  G01N33/531 ,  G01N33/543

CPC分类号： C07D495/04 ,  C07H15/203 ,  G01N33/531 ,  G01N33/54353 ,  Y10S435/961 ,  Y10S435/97 ,  Y10S530/813

公开(公告)号：EP1538156A1

公开(公告)日：2005-06-08

申请号：EP03794278.6

申请日：2003-09-08

申请人： Japan Science and Technology Agency ,  National University Corporation Kagoshima University

发明人： SUDA, Yasuo ,  ARANO, Akio ,  KUSUMOTO, Shoichi ,  SOBEL, Michael

IPC分类号： C07K5/027 ,  C07K9/00 ,  C07K1/06 ,  C07H15/04 ,  C07D339/04 ,  G01N33/543

CPC分类号： C07H15/04 ,  A61K47/549 ,  C07D339/04 ,  C07D409/14 ,  Y10S435/961 ,  Y10S435/97

摘要： A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group at an end and a carbon-nitrogen bond in a backbone. A ligand includes the linker compound and a sugar introduced into the linker compound.

摘要翻译： 连接体化合物具有下述通式（1）表示的结构，其中n为1〜6的整数，X为具有多支链结构部分的结构，包括三个或四个各自具有芳香族氨基的烃衍生物链 末端的基团和骨架中的碳 - 氮键。 配体包括连接体化合物和引入接头化合物的糖。

公开(公告)号：EP1731517B1

公开(公告)日：2010-11-17

申请号：EP05709791.7

申请日：2005-02-04

申请人： Japan Science and Technology Agency ,  National University Corporation Kagoshima University

发明人： SUDA, Yasuo ,  ARANO, Akio ,  KUSUMOTO, Shoichi ,  SOBEL, Michael ,  WAKAO, Masahiro

IPC分类号： C07D339/04 ,  C07H15/04 ,  G01N33/543

CPC分类号： C07H15/04 ,  C07D339/04 ,  G01N33/54353

摘要： A novel linker compound that minimizes any nonspecific hydrophobic interactions and is capable of easily regulating the length to disulfide group subjected to metal bond to thereby enable efficient formation of metal-sulfur bond; a novel ligand complex or ligand carrying substance; and a process for producing them. There is provided a linker compound comprising the structure of the general formula: (1) (wherein each of a, b, d and e independently is an integer of 0 to 6). The above X at a molecular end has an aromatic amino group and at its main chain has a structure of multi-branched structural site composed of 3 or more hydrocarbon-derived chains optionally having carbon-nitrogen bonds. The ligand complex consists of the above linker compound having a sugar molecule introduced therein.

公开(公告)号：EP1731517A1

公开(公告)日：2006-12-13

申请号：EP05709791.7

申请日：2005-02-04

申请人： Japan Science and Technology Agency ,  National University Corporation Kagoshima University

发明人： SUDA, Yasuo ,  ARANO, Akio ,  KUSUMOTO, Shoichi ,  SOBEL, Michael ,  WAKAO, Masahiro

IPC分类号： C07D339/04 ,  C07H15/04

CPC分类号： C07H15/04 ,  C07D339/04 ,  G01N33/54353

摘要： The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1)

where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.

摘要翻译： 本发明提供了一种新的接头化合物，其使任何非特异性疏水相互作用最小化，并且能够容易地将长度调节至经受金属键的二硫键，从而有效形成金属 - 硫键; 新型配体结合物和配体载体，及其制备方法。 连接体化合物具有下述通式（1）所示的结构，其中a，b，d，e独立地为0〜6的整数。X具有作为多支链结构部分的结构，包含3个以上的烃 衍生链，其中烃衍生物链各自在其末端包括芳族氨基，并且在其主链中可以包括或不包括碳 - 氮键。 配体缀合物包括其中引入糖分子的连接体化合物。

公开(公告)号：EP1548016A1

公开(公告)日：2005-06-29

申请号：EP03794076.4

申请日：2003-08-06

申请人： Japan Science and Technology Agency ,  National University Corporation Kagoshima University

发明人： SUDA, Yasuo ,  ARANO, Akio ,  HAYASHI, Hideki ,  KUSUMOTO, Shoichi ,  SOBEL, Michael

IPC分类号： C07D495/04 ,  C07H15/203 ,  G01N33/53 ,  G01N33/566

CPC分类号： C07D495/04 ,  C07H15/203 ,  G01N33/531 ,  G01N33/54353 ,  Y10S435/961 ,  Y10S435/97 ,  Y10S530/813

摘要： A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aromatic amino group at an end thereof, and may or may not have a carbon-nitrogen bond in a backbone thereof. With the versatile linker compound, sugar molecules can be two-dimensionally arranged on a surface of a protein-analyzing supporter with high reproducibility. Also, a ligand includes the versatile linker compound and a sugar molecule introduced thereinto.

摘要翻译： 通用的连接体化合物具有下列通式（1）所示的结构，其中Y具有由O或NH表示的结构，X具有用作多支链部分的结构，包括四个烃衍生物链，其各自具有芳族 氨基，其主链可以具有或不具有碳 - 氮键。 通过多功能接头化合物，糖分子可以二维排列在蛋白质分析支持物的表面上，具有高重现性。 此外，配体包括通用的连接物化合物和引入其中的糖分子。