公开(公告)号：EP3875200A1

公开(公告)日：2021-09-08

申请号：EP19879971.0

申请日：2019-10-24

申请人： Ayabo Corporation ,  National University Corporation Kagoshima University ,  NATIONAL UNIVERSITY CORPORATION OITA UNIVERSITY

发明人： MATSUZAKI, Kenichiro ,  RYU, Takahiro ,  TSUKAMOTO, Keizo

IPC分类号： B23D77/00

摘要： To provide a method for simply evaluating results of simulations based on the Matsuzaki-Ryu model.
A hole drilling tool for forming holes, including a plurality of cutting edges, wherein, when each of the cutting edges is applied to a characteristic equation of the Matsuzaki-Ryu model, an integer value closest to an imaginary part of a quasi-static characteristic root s, which is a characteristic root at a frequency ω = 0, is set to N 0 , and, when a maximum real part of the quasi-static characteristic root s which satisfies 3 ≤ N 0 ≤ 2n + 1 (n is the number of the cutting edges) is a maximum real part σ MAX , a maximum real part Tσ MAX of the hole drilling tool is within a predetermined threshold value with respect to a maximum real part Rσ MAX of a reference hole drilling tool.

公开(公告)号：EP1548016B1

公开(公告)日：2015-05-20

申请号：EP03794076.4

申请日：2003-08-06

申请人： Japan Science and Technology Agency ,  National University Corporation Kagoshima University

发明人： SUDA, Yasuo ,  ARANO, Akio ,  HAYASHI, Hideki ,  KUSUMOTO, Shoichi ,  SOBEL, Michael

IPC分类号： C07D495/04 ,  C07H15/203 ,  G01N33/531 ,  G01N33/543

CPC分类号： C07D495/04 ,  C07H15/203 ,  G01N33/531 ,  G01N33/54353 ,  Y10S435/961 ,  Y10S435/97 ,  Y10S530/813

公开(公告)号：EP2428578A1

公开(公告)日：2012-03-14

申请号：EP10772125.0

申请日：2010-05-10

申请人： National University Corporation Kagoshima University ,  Ezaki Glico Co., Ltd.

发明人： KADOKAWA, Junichi ,  TAKAHA, Takeshi ,  KUBO, Akiko ,  YANASE, Michiyo ,  HOSOYA, Kayo

IPC分类号： C12P19/04 ,  A61K47/36 ,  C08B37/00 ,  C12N15/09 ,  C12N9/12

CPC分类号： A61K47/36 ,  A61K49/0002 ,  C08B37/0009 ,  C12N9/1051 ,  C12P19/04 ,  C12Y204/01001

摘要： An object of the present invention is to provide a uronic acid-containing glucan or a modified product thereof. The glucuronic acid-containing glucan of the present invention is a glucuronic acid-containing glucan in which a glucuronic acid residue is bound to at least one non-reducing end of a glucan, and the glucan is a branched α-1,4 glucan or a linear α-1,4 glucan. The glucuronic acid-containing glucan of the present invention can be provided by allowing α-glucan phosphorylase derived from Aquifex aeolicus VF5 to act on glucuronic acid-1-phosphate to thereby transfer a glucuronic acid residue to the non-reducing end of the receptor glucan.

摘要翻译： 本发明的目的是提供一种含糖醛酸的葡聚糖或其改性产物。 本发明的含葡萄糖醛酸的葡聚糖是葡萄糖醛酸的葡聚糖，其中葡萄糖醛酸残基与葡聚糖的至少一个非还原末端结合，葡聚糖是支链的±-1,4葡聚糖或 线性±-1,4葡聚糖。 本发明的含葡萄糖醛酸的葡聚糖可以通过使得来自Aquifex aeolicus VF5的±葡聚糖磷酸化酶作用于葡糖醛酸-1-磷酸酯上，从而将葡萄糖醛酸残基转移到受体葡聚糖的非还原末端来提供 。

公开(公告)号：EP1726596A1

公开(公告)日：2006-11-29

申请号：EP05710751.8

申请日：2005-02-18

申请人： Japan Science and Technology Agency ,  National University Corporation Kagoshima University

发明人： SUDA, Yasuo

IPC分类号： C07H15/04 ,  C07D339/04 ,  G01N27/62 ,  G01N33/53

CPC分类号： G01N33/52 ,  C07H15/04 ,  G01N33/531 ,  G01N2400/00

摘要： A novel ligand conjugate which is effectively utilizable for analyzing a function of a protein; a ligand-supporting object; and a method of analyzing a protein. The ligand conjugate has a structure which comprises: a linker compound having a structure represented by the following General Formula (1):

(wherein n and p each is an integer of 0 to 6) in which X is a structure comprising one, two, or three hydrocarbon derivative chains which have an aromatic amino group at the end and may have a carbon-nitrogen bond in the main chain, Y is a hydro-carbon structure containing one or more sulfur atoms, and Z is a straight-chain structure comprising a carbon-carbon bond or carbon-oxygen bond; and a sugar which has a reducing end and is bonded to the linker compound through the aromatic amino group.

摘要翻译： 一种可有效用于分析蛋白质功能的新配体结合物; 配体支持物; 和分析蛋白质的方法。 所述配体缀合物具有这样的结构，其包含：具有由以下通式（1）表示的结构的连接体化合物：其中n和p各自为0至6的整数，其中X为包含一个，两个， 或在末端具有芳香族氨基，在主链上具有碳 - 氮键的三个烃衍生物链，Y是含有一个以上的硫原子的烃结构，Z是直链结构，该直链结构包含 碳 - 碳键或碳 - 氧键; 以及具有还原端并且通过芳香族氨基与接头化合物结合的糖。

公开(公告)号：EP1909104B1

公开(公告)日：2010-07-21

申请号：EP06746921.3

申请日：2006-05-26

申请人： Japan Science and Technology Agency ,  National University Corporation Kagoshima University ,  Suda, Yasuo

发明人： SUDA, Yasuo ,  NISHIMURA, Tomoaki ,  KISHIMOTO, Yuko ,  NAKAGAWA, Hiromi

IPC分类号： G01N33/543 ,  G01N33/553 ,  G01N33/58 ,  C07K1/22

CPC分类号： C07K17/14 ,  B82Y5/00 ,  C07K1/22 ,  G01N33/54346 ,  G01N33/553 ,  G01N33/587 ,  G01N2400/00

摘要： It is intended to provide a stable novel sugar-immobilized metal nanoparticle capable of easily immobilizing a sugar chain, a method for measuring sugar-protein interaction easily and at a low cost using the same without labeling, and a method for simply recovering a protein from a sugar-protein interactant. A maltose-immobilized gold nanoparticle was obtained by binding a ligand complex, in which maltose and a linker compound had been bound to each other, to a gold nanoparticle. By adding this maltose-immobilized gold nanoparticle to a dilution series of concanavalin A, a sugar-protein interactant of maltose and ConA was formed, and red-purple color derived from a colloidal solution of maltose-immobilized gold nanoparticle disappeared. That is, sugar-protein interaction could be confirmed by visual observation without labeling.

公开(公告)号：EP1909104A1

公开(公告)日：2008-04-09

申请号：EP06746921.3

申请日：2006-05-26

申请人： Japan Science and Technology Agency ,  National University Corporation Kagoshima University ,  Suda, Yasuo

发明人： NISHIMURA, Tomoaki ,  KISHIMOTO, Yuko ,  NAKAGAWA, Hiromi ,  SUDA, Yasuo

IPC分类号： G01N33/543 ,  C07K1/22 ,  G01N33/553

CPC分类号： C07K17/14 ,  B82Y5/00 ,  C07K1/22 ,  G01N33/54346 ,  G01N33/553 ,  G01N33/587 ,  G01N2400/00

摘要： It is intended to provide a stable novel sugar-immobilized metal nanoparticle capable of easily immobilizing a sugar chain, a method for measuring sugar-protein interaction easily and at a low cost using the same without labeling, and a method for simply recovering a protein from a sugar-protein interactant. A maltose-immobilized gold nanoparticle was obtained by binding a ligand complex, in which maltose and a linker compound had been bound to each other, to a gold nanoparticle. By adding this maltose-immobilized gold nanoparticle to a dilution series of concanavalin A, a sugar-protein interactant of maltose and ConA was formed, and red-purple color derived from a colloidal solution of maltose-immobilized gold nanoparticle disappeared. That is, sugar-protein interaction could be confirmed by visual observation without labeling.

摘要翻译： 它的目的是提供一个稳定的新颖糖固定化的金属纳米颗粒能够容易地固定的糖链中，用于测量糖 - 蛋白质相互作用容易且使用相同的无标记的低成本的方法，以及用于简单地从回收的蛋白质的方法 糖蛋白相互作用物。 麦芽糖固定金纳米粒子通过什么结合的配体复合物，其中麦芽糖和左复合已被绑定到海誓山盟，到金纳米粒子获得。 通过添加该麦芽糖固定化的金纳米颗粒的稀释系列伴刀豆球蛋白A的，麦芽糖和刀豆的糖 - 蛋白相互作用物从麦芽糖固定化金纳米颗粒的胶体溶液衍生什么形成，并且红紫色消失。 即，糖 - 蛋白质相互作用可通过无标记视觉观察来确认。

公开(公告)号：EP1538156A1

公开(公告)日：2005-06-08

申请号：EP03794278.6

申请日：2003-09-08

申请人： Japan Science and Technology Agency ,  National University Corporation Kagoshima University

发明人： SUDA, Yasuo ,  ARANO, Akio ,  KUSUMOTO, Shoichi ,  SOBEL, Michael

IPC分类号： C07K5/027 ,  C07K9/00 ,  C07K1/06 ,  C07H15/04 ,  C07D339/04 ,  G01N33/543

CPC分类号： C07H15/04 ,  A61K47/549 ,  C07D339/04 ,  C07D409/14 ,  Y10S435/961 ,  Y10S435/97

摘要： A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group at an end and a carbon-nitrogen bond in a backbone. A ligand includes the linker compound and a sugar introduced into the linker compound.

摘要翻译： 连接体化合物具有下述通式（1）表示的结构，其中n为1〜6的整数，X为具有多支链结构部分的结构，包括三个或四个各自具有芳香族氨基的烃衍生物链 末端的基团和骨架中的碳 - 氮键。 配体包括连接体化合物和引入接头化合物的糖。

公开(公告)号：EP3783016A1

公开(公告)日：2021-02-24

申请号：EP19787597.4

申请日：2019-04-15

申请人： Nihon Medi-Physics Co., Ltd ,  National University Corporation Kagoshima University ,  National University Corporation Chiba University

发明人： KOMOTO Shota ,  OGAWA Yu ,  SHOYAMA Yoshinari ,  HATANO Tadashi ,  ITO Yuji ,  ARANO Yasushi ,  SUZUKI Hiroyuki ,  UEHARA Tomoya

IPC分类号： C07K16/00 ,  A61K39/395 ,  A61K47/68 ,  A61K47/69 ,  A61K51/10 ,  C07D257/02 ,  C07K7/06 ,  C07K7/08 ,  C07K19/00

摘要： The present invention relates to a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and provides a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.

公开(公告)号：EP1731517A1

公开(公告)日：2006-12-13

申请号：EP05709791.7

申请日：2005-02-04

申请人： Japan Science and Technology Agency ,  National University Corporation Kagoshima University

发明人： SUDA, Yasuo ,  ARANO, Akio ,  KUSUMOTO, Shoichi ,  SOBEL, Michael ,  WAKAO, Masahiro

IPC分类号： C07D339/04 ,  C07H15/04

CPC分类号： C07H15/04 ,  C07D339/04 ,  G01N33/54353

摘要： The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1)

where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.

摘要翻译： 本发明提供了一种新的接头化合物，其使任何非特异性疏水相互作用最小化，并且能够容易地将长度调节至经受金属键的二硫键，从而有效形成金属 - 硫键; 新型配体结合物和配体载体，及其制备方法。 连接体化合物具有下述通式（1）所示的结构，其中a，b，d，e独立地为0〜6的整数。X具有作为多支链结构部分的结构，包含3个以上的烃 衍生链，其中烃衍生物链各自在其末端包括芳族氨基，并且在其主链中可以包括或不包括碳 - 氮键。 配体缀合物包括其中引入糖分子的连接体化合物。

公开(公告)号：EP1548016A1

公开(公告)日：2005-06-29

申请号：EP03794076.4

申请日：2003-08-06

申请人： Japan Science and Technology Agency ,  National University Corporation Kagoshima University

发明人： SUDA, Yasuo ,  ARANO, Akio ,  HAYASHI, Hideki ,  KUSUMOTO, Shoichi ,  SOBEL, Michael

IPC分类号： C07D495/04 ,  C07H15/203 ,  G01N33/53 ,  G01N33/566

CPC分类号： C07D495/04 ,  C07H15/203 ,  G01N33/531 ,  G01N33/54353 ,  Y10S435/961 ,  Y10S435/97 ,  Y10S530/813

摘要： A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aromatic amino group at an end thereof, and may or may not have a carbon-nitrogen bond in a backbone thereof. With the versatile linker compound, sugar molecules can be two-dimensionally arranged on a surface of a protein-analyzing supporter with high reproducibility. Also, a ligand includes the versatile linker compound and a sugar molecule introduced thereinto.

摘要翻译： 通用的连接体化合物具有下列通式（1）所示的结构，其中Y具有由O或NH表示的结构，X具有用作多支链部分的结构，包括四个烃衍生物链，其各自具有芳族 氨基，其主链可以具有或不具有碳 - 氮键。 通过多功能接头化合物，糖分子可以二维排列在蛋白质分析支持物的表面上，具有高重现性。 此外，配体包括通用的连接物化合物和引入其中的糖分子。